Anti-GluA1-GluR1 Antibody | QED Bioscience 56547 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-GluA1-GluR1 Antibody

catalog :

56547

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S355-1

The same clone is also sold as:

Novus Biologicals: NBP2-22399
OriGene: TA326534

reactivity :

mouse, rat

product information

CATALOG NUMBER :

56547

PRODUCT NAME :

Anti-GluA1-GluR1 Antibody

NAME+SKU :

Anti-GluA1-GluR1 Antibody (56547)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-GluA1/GluR1 Mouse Monoclonal Antibody

SPECIFICITY SHORT :

GluA1/GluR1

SPECIES REACTIVITY :

Mouse, rat

TARGET NAME :

GluA1-GluR1

UNIPROT :

P19490

LOCATION :

Cell membrane , Endoplasmic reticulum membrane , Cell junction, synapse, postsynaptic cell membrane , Cell junction, synapse, postsynaptic density membrane , Cell projection, dendrite , Cell projection, dendritic spine , Early endosome membrane , Recycling endosome membrane , Cell junction, synapse, presynapse , Cell junction, synapse

PROTEIN NAME :

Glutamate receptor 1

ALTERNATIVE NAMES :

GluR-1, AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1

GENE NAME :

Gria1

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

305.2

SKU SIZE 1 :

56547

APPLICATIONS :

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1ug/ml. A band of ~100kDa is detected. Positive control: Rat brain lysate. These are recommended concentrations. User should determine optimal concentrations for their application.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

S355-1

IMMUNOGEN :

Fusion protein corresponding to aa 1-389 (extracellular N-terminus) of rat GluA1/GluR1 (accession no. P19490).

RESEARCH AREA :

Neuroscience

FORMULATION :

PBS, pH 7.4; 50% glycerol, 0.09% sodium azide.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER ANTI-MICROBIAL :

0.09% Sodium Azide

BUFFER CRYOPRESERVATIVE :

50% Glycerol

TARGET BACKGROUND :

Regulation of alpha-amino-3-hydroxy-5- methyl-4-isoxazole propionic acid receptors (AMPARs) plays a key role in altering excitatory synaptic transmission in the CNS. Interestingly, the regulatory mechanisms differ between distinct subunits of AMPAR, which range from glutamate receptor 1 (GluR1) to GluR4 (also referred to as GluA1â€“4). For example, subunits with a long intracellular carboxy terminus (i.e., GluR1, GluR2L, and GluR4) are involved in activity- dependent synaptic targeting of AMPAR, whereas those with a shorter carboxy terminus (i.e., GluR2, GluR3, and GluR4s) seem to maintain basal synaptic transmission. GluR1 has several phosphorylation sites on the intracellular carboxy terminus. Many of these sites have been demonstrated to play a role in synaptic AMPAR regulation and synaptic plasticity.

FUNCTION :

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {PubMed:16793768, PubMed:19265014}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for at least one (1) year at -20C. Avoid repeated freezing and thawing.

SPECIFICITY :

This antibody recognizes mouse and rat GluA1/GluR1. It does not cross-react with GluR2.

Image Name_1 :

qed-bioscience-anti-glua1-glur1-antibody-56547-1.png

Applications 1 :

ICC

Image Name_2 :

qed-bioscience-anti-glua1-glur1-antibody-56547-2.png

Applications 2 :

Western Blot

Image Name_3 :

qed-bioscience-anti-glua1-glur1-antibody-56547-3.png

Applications 3 :

ICC