Anti-Brevican Antibody | QED Bioscience 56541 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Brevican Antibody

catalog :

56541

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S294A-6

The same clone is also sold as:

OriGene: TA326514
Novus Biologicals: NBP2-22401

reactivity :

mouse, rat

product information

CATALOG NUMBER :

56541

PRODUCT NAME :

Anti-Brevican Antibody

NAME+SKU :

Anti-Brevican Antibody (56541)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Brevican Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Brevican

SPECIES REACTIVITY :

Mouse, rat

TARGET NAME :

Brevican

UNIPROT :

P55068

LOCATION :

[Isoform 1]: Secreted, extracellular space, extracellular matrix.; [Isoform 2]: Membrane; Lipid-anchor, GPI-anchor.

PROTEIN NAME :

Brevican core protein

ALTERNATIVE NAMES :

Brain-enriched hyaluronan-binding protein, BEHAB

GENE NAME :

Bcan

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

305.2

SKU SIZE 1 :

56541

APPLICATIONS :

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-2ug/ml. A band of ~140kDa is detected. Smaller cleavage products are also detected. Positive control: Rat brain lysate. These are recommended concentrations. User should determine optimal concentrations for their application.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG2b

CLONE ID :

S294A-6

IMMUNOGEN :

Fusion protein corresponding to aa 219-655 of rat Brevican (accession no. P55068).

RESEARCH AREA :

Neuroscience

FORMULATION :

PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER ANTI-MICROBIAL :

0.09% Sodium Azide

BUFFER CRYOPRESERVATIVE :

50% Glycerol

TARGET BACKGROUND :

Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a145kDa core protein that bears up to three covalently-linked CS chains. It is also is secreted as a 145kDa core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, a 55kDa N-terminal fragment is formed that contains the unique C-terminal epitope EAMESE.

FUNCTION :

May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Isoform 2 may function as a chondroitin sulfate-bearing cell surface receptor.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for at least one (1) year at -20C. Avoid repeated freeze- thaw cycles.

SPECIFICITY :

This antibody recognizes mouse and rat Brevican.

Image Name_1 :

qed-bioscience-anti-brevican-antibody-56541-1.png

Applications 1 :

ICC

Image Name_2 :

qed-bioscience-anti-brevican-antibody-56541-2.png

Applications 2 :

Western Blot

Image Name_3 :

qed-bioscience-anti-brevican-antibody-56541-3.png

Applications 3 :

ICC