Anti-Alpha 2c Adrenergic Receptor Antibody | QED Bioscience 56529 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Alpha 2c Adrenergic Receptor Antibody

catalog :

56529

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S330A-80

The same clone is also sold as:

Novus Biologicals: NBP2-22397
OriGene: TA326436

reactivity :

human, mouse

product information

CATALOG NUMBER :

56529

PRODUCT NAME :

Anti-Alpha 2c Adrenergic Receptor Antibody

NAME+SKU :

Anti-Alpha 2c Adrenergic Receptor Antibody (56529)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Alpha-2C Adrenergic Receptor Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Alpha-2C Adrenergic Receptor

SPECIES REACTIVITY :

Human, mouse

TARGET NAME :

Alpha 2c Adrenergic Receptor

UNIPROT :

P18825

LOCATION :

Cell membrane; Multi-pass membrane protein.

PROTEIN NAME :

Alpha-2C adrenergic receptor

ALTERNATIVE NAMES :

Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2C adrenoceptor, Alpha-2CAR

GENE NAME :

ADRA2C

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

1.0 mg/mL

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

305.2

SKU SIZE 1 :

56529

APPLICATIONS :

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1ug/ml. Predicted molecular weight is ~50kDa or larger (possibly due to dimerization). These are recommended concentrations. Endusers should determine optimal concentrations for their applications.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

S330A-80

IMMUNOGEN :

Synthetic peptide corresponding to aa 442-462 (QDFRRSFFKHILFRRRRRGFQ), the cytoplasmic C-terminus, of human Alpha-2C adrenergic receptor (accession no. P18825).

RESEARCH AREA :

Neuroscience

FORMULATION :

PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER ANTI-MICROBIAL :

0.09% Sodium Azide

BUFFER CRYOPRESERVATIVE :

50% Glycerol

TARGET BACKGROUND :

The alpha-2C adrenergic receptor (also known as ADRA2C) controls the release of neurotransmitters from central adrenergic neurons and from sympathetic nerves in the heart. There are three subtypes of the alpha-2 adrenergic receptor: alpha-2A, alpha-2B, and alpha-2C. The human alpha-2A subtype undergoes phosphorylation and short-term desensitization, whereas the human alpha-2C subtype is not phosphorylated and does not desensitize. The human alpha-2C subtype, however, does undergo arrestin-dependent internalization. In contrast to alpha-2A and alpha-2B adrenergic receptors from several species, the human alpha-2C receptor does not appear to down-regulate in response to agonist treatment in transfected cell culture systems.

FUNCTION :

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This product is stable for at least 1 year at -20C. Freeze in multiple aliquots to avoid repeated freeze-thaw cycles.

SPECIFICITY :

This antibody recognizes human and mouse Alpha-2C adrenergic receptor.

Image Name_1 :

qed-bioscience-anti-alpha-2c-adrenergic-receptor-antibody-56529-1.png

Applications 1 :

ICC

Image Name_2 :

qed-bioscience-anti-alpha-2c-adrenergic-receptor-antibody-56529-2.png

Applications 2 :

ICC

Image Name_3 :

qed-bioscience-anti-alpha-2c-adrenergic-receptor-antibody-56529-3.png

Applications 3 :

Western Blot