Anti-NR1 Glutamate Receptor Antibody | QED Bioscience 56525 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-NR1 Glutamate Receptor Antibody

catalog :

56525

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S308-48

The same clone is also sold as:

Abcam: ab134308
Novus Biologicals: NBP2-59327
OriGene: TA326536

reactivity :

human, mouse, rat

product information

CATALOG NUMBER :

56525

PRODUCT NAME :

Anti-NR1 Glutamate Receptor Antibody

NAME+SKU :

Anti-NR1 Glutamate Receptor Antibody (56525)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-NR1 Glutamate Receptor Mouse Monoclonal Antibody

SPECIFICITY SHORT :

NR1 Glutamate Receptor

SPECIES REACTIVITY :

Human, mouse, rat

TARGET NAME :

NR1 Glutamate Receptor

UNIPROT :

P35439

LOCATION :

Cell membrane , Cell junction, synapse, postsynaptic cell membrane , Cell junction, synapse, postsynaptic density

PROTEIN NAME :

Glutamate receptor ionotropic, NMDA 1

ALTERNATIVE NAMES :

GluN1, Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, NMD-R1

GENE NAME :

Grin1

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

1.0 mg/mL

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

305.2

SKU SIZE 1 :

56525

APPLICATIONS :

WB, IHC

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-2ug/ml. A band of ~105kDa is detected. Immunohistochemistry: use at 1-5ug/ml. These are recommended concentrations. Enduser should determine optimal concentrations for their applications. Positive control: Rat brain membranes.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

S308-48

IMMUNOGEN :

Fusion protein corresponding to aa 42-361 (extracellular N-terminus) of rat NR1 (accession no. NP_058706.1).

RESEARCH AREA :

Neuroscience

FORMULATION :

PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER ANTI-MICROBIAL :

0.09% Sodium Azide

BUFFER CRYOPRESERVATIVE :

50% Glycerol

TARGET BACKGROUND :

The NMDA receptor (NMDAR), a glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function. NMDAR is a heterotetramer of two NR1 and two NR2 subunits. Multiple receptor isoforms with distinct brain distributions and functional properties arise by selective splicing of the NR1 transcripts and differential expression of the NR2 subunits.

FUNCTION :

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1350383, PubMed:1834949, PubMed:1388270, PubMed:8428958, PubMed:18177891, PubMed:28384476, PubMed:15996549, PubMed:24876489, PubMed:27135925, PubMed:27618671, PubMed:28468946). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:28384476). {PubMed:1350383, PubMed:1388270, PubMed:15996549, PubMed:18177891, PubMed:1834949, PubMed:24876489, PubMed:27135925, PubMed:27618671, PubMed:28384476, PubMed:28468946, PubMed:8428958}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This product is stable for at least 1 year at -20C. Freeze in multiple aliquots to avoid repeated freeze-thaw cycles.

SPECIFICITY :

This antibody recognizes human, mouse, and rat NR1.

Image Name_1 :

qed-bioscience-anti-nr1-glutamate-receptor-antibody-56525-1.png

Applications 1 :

ICC

Image Name_2 :

qed-bioscience-anti-nr1-glutamate-receptor-antibody-56525-2.png

Applications 2 :

Western Blot

Image Name_3 :

qed-bioscience-anti-nr1-glutamate-receptor-antibody-56525-3.png

Applications 3 :

ICC