Anti-pan-Shank Antibody | QED Bioscience 56468 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-pan-Shank Antibody

catalog :

56468

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S23b-49

The same clone is also sold as:

Rockland Immunochemicals: 200-301-G42
OriGene: TA326583

reactivity :

human, mouse, rat

product information

CATALOG NUMBER :

56468

PRODUCT NAME :

Anti-pan-Shank Antibody

NAME+SKU :

Anti-pan-Shank Antibody (56468)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-pan-Shank Mouse Monoclonal Antibody

SPECIFICITY SHORT :

pan-Shank

SPECIES REACTIVITY :

Human, mouse, rat

TARGET NAME :

pan-Shank

UNIPROT :

Q9QX74

LOCATION :

Apical cell membrane , Cytoplasm , Cell junction, synapse , Cell junction, synapse, postsynaptic density , Cell projection, growth cone , Cell projection, dendritic spine

PROTEIN NAME :

SH3 and multiple ankyrin repeat domains protein 2

ALTERNATIVE NAMES :

Shank2, Cortactin-binding protein 1, CortBP1, GKAP/SAPAP-interacting protein, Proline-rich synapse-associated protein 1, ProSAP1, SPANK-3

GENE NAME :

Shank2

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

305.2

SKU SIZE 1 :

56468

APPLICATIONS :

WB, IHC, ICC, IF

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-10ug/ml. A band of ~160kDa is detected. Immunohistochemistry and Immunocytochemistry: use at 0.1-1ug/ml Immunofluorescence: use at 1-10ug/ml These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Adult rat brain lysate.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

S23b-49

IMMUNOGEN :

Fusion protein corresponding to aa 84-309 (SH3/PDZ domains) of rat Shank2 (accession no. Q9QX74). This sequence is 94

RESEARCH AREA :

Neuroscience

FORMULATION :

PBS, pH 7.4; 50% glycerol, 0.09% sodium azide.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER ANTI-MICROBIAL :

0.09% Sodium Azide

BUFFER CRYOPRESERVATIVE :

50% Glycerol

TARGET BACKGROUND :

Shank proteins are a family of scaffold proteins identified through their interaction with a variety of membrane and cyto- plasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are crucial in receptor tyrosine kinase signaling. Recent studies suggest that disruption of glutamate receptors at the Shank-postsynaptic platform could contribute to the destruction of post- synaptic density which underlies synaptic dysfunction and loss in Alzheimerâ€™s disease.

FUNCTION :

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. {PubMed:10506216}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for at least one (1) year at -20C. Avoid repeated freezing and thawing.

SPECIFICITY :

This antibody recognizes human, mouse, and rat Shank 1, 2, and 3.

Image Name_1 :

qed-bioscience-anti-pan-shank-antibody-56468-1.png

Applications 1 :

Western Blot

Image Name_2 :

qed-bioscience-anti-pan-shank-antibody-56468-2.png

Applications 2 :

ICC

Image Name_3 :

qed-bioscience-anti-pan-shank-antibody-56468-3.png

Applications 3 :

ICC