Anti-Alpha 1 GABA-A Receptor Antibody | QED Bioscience 56467 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Alpha 1 GABA-A Receptor Antibody

catalog :

56467

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S95-35

The same clone is also sold as:

OriGene: TA326472

reactivity :

human, mouse, rat

product information

CATALOG NUMBER :

56467

PRODUCT NAME :

Anti-Alpha 1 GABA-A Receptor Antibody

NAME+SKU :

Anti-Alpha 1 GABA-A Receptor Antibody (56467)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Alpha 1 GABA-A Receptor Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Alpha 1 GABA-A Receptor

SPECIES REACTIVITY :

Human, mouse, rat

TARGET NAME :

Alpha 1 GABA-A Receptor

UNIPROT :

P14867

LOCATION :

Cell junction, synapse, postsynaptic cell membrane , Cell membrane , Cytoplasmic vesicle membrane

PROTEIN NAME :

Gamma-aminobutyric acid receptor subunit alpha-1

ALTERNATIVE NAMES :

GABA(A receptor subunit alpha-1

GENE NAME :

GABRA1

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

305.2

SKU SIZE 1 :

56467

APPLICATIONS :

WB, IHC, ICC, IF

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-10ug/ml. A band of ~55kDa is detected. Immunohistochemistry and Immunocytochemistry: use at 0.1-1ug/ml Immunofluorescence: use at 1-10ug/ml These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain lysate.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG2a

CLONE ID :

S95-35

IMMUNOGEN :

Fusion protein corresponding to aa 355-394 of mouse Alpha 1 GABA-A receptor (accession no. P62812).

RESEARCH AREA :

Neuroscience

FORMULATION :

PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER ANTI-MICROBIAL :

0.09% Sodium Azide

BUFFER CRYOPRESERVATIVE :

50% Glycerol

TARGET BACKGROUND :

GABA is the major inhibitory neuro- transmitter in the vertebrate brain. GABA receptors consist of five subunits that form a chloride ion channel. Subunit families alpha, beta, gamma, and delta have been studied extensively; Ï€ and epsilon have been identified recently. Studies of recombinant GABA receptors have shown that individual subunits and their subtypes confer different sensitivities to GABA receptor modulators. Subunit subtypes are differentially expressed throughout development and in different CNS regions, reducing the total number of possible isoforms that can be formed in different brain regions and in individual cells.

FUNCTION :

Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:23909897, PubMed:25489750, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). {UniProtKB:P62812, UniProtKB:P62813, PubMed:23909897, PubMed:25489750, PubMed:29950725}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for at least one (1) year at -20C. Avoid repeated freezing and thawing.

SPECIFICITY :

This antibody recognizes human, mouse, and rat Alpha 1 GABA-A receptor. It does not cross-react with Alpha 2 or Alpha 3 GABA-A receptors.

Image Name_1 :

qed-bioscience-anti-alpha-1-gaba-a-receptor-antibody-56467-1.png

Applications 1 :

IHC

Image Name_2 :

qed-bioscience-anti-alpha-1-gaba-a-receptor-antibody-56467-2.png

Applications 2 :

Western Blot

Image Name_3 :

qed-bioscience-anti-alpha-1-gaba-a-receptor-antibody-56467-3.png

Applications 3 :

ICC