Anti-Shank 2 Antibody | QED Bioscience 56466 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Shank 2 Antibody

catalog :

56466

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S23b-6

The same clone is also sold as:

Rockland Immunochemicals: 200-301-G44
OriGene: TA309475

reactivity :

human, mouse, rat

product information

CATALOG NUMBER :

56466

PRODUCT NAME :

Anti-Shank 2 Antibody

NAME+SKU :

Anti-Shank 2 Antibody (56466)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Shank2 Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Shank2

SPECIES REACTIVITY :

Human, mouse (weak), rat

TARGET NAME :

Shank 2

UNIPROT :

Q9QX74

LOCATION :

Apical cell membrane , Cytoplasm , Cell junction, synapse , Cell junction, synapse, postsynaptic density , Cell projection, growth cone , Cell projection, dendritic spine

PROTEIN NAME :

SH3 and multiple ankyrin repeat domains protein 2

ALTERNATIVE NAMES :

Shank2, Cortactin-binding protein 1, CortBP1, GKAP/SAPAP-interacting protein, Proline-rich synapse-associated protein 1, ProSAP1, SPANK-3

GENE NAME :

Shank2

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

305.2

SKU SIZE 1 :

56466

APPLICATIONS :

WB, IHC, ICC, IF

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-10ug/ml. A band of ~160kDa is detected. Immunohistochemistry and Immunocytochemistry: use at 0.1-1ug/ml Immunofluorescence: use at 1-10ug/ml These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Adult rat brain lysate.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

S23b-6

IMMUNOGEN :

Fusion protein corresponding to aa 84-309 (SH3/PDZ domains) of rat Shank2 (accession no. Q9QX74). This sequence is 94

RESEARCH AREA :

Neuroscience

FORMULATION :

PBS, pH 7.4; 50% glycerol, 0.09% sodium azide.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER ANTI-MICROBIAL :

0.09% Sodium Azide

BUFFER CRYOPRESERVATIVE :

50% Glycerol

TARGET BACKGROUND :

Shank proteins are a family of scaffold proteins identified through their interaction with a variety of membrane and cyto- plasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are crucial in receptor tyrosine kinase signaling. Shank2 is expressed in neurons of the developing retina and could play a role in neuronal differentiation of the developing retina. Recent studies suggest that disruption of glutamate receptors at the Shank-postsynaptic platform could contribute to the destruction of post-synaptic density which underlies synaptic dysfunction and loss in Alzheimerâ€™s disease.

FUNCTION :

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. {PubMed:10506216}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for 1 month at 4°C or one year at -20°C. Avoid multiple freeze-thaw cycles.

SPECIFICITY :

This antibody recognizes human, mouse (weak), and rat Shank2. It does not cross- react with Shank1 or Shank3.

Image Name_2 :

qed-bioscience-anti-shank-2-antibody-56466-2.png

Applications 2 :

ICC

Image Name_3 :

qed-bioscience-anti-shank-2-antibody-56466-3.png

Applications 3 :

Western Blot