Anti-LAMP1 Antibody | QED Bioscience 56270 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-LAMP1 Antibody

catalog :

56270

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Ly1C6

The same clone is also sold as:

Rockland Immunochemicals: 200-301-G09
Invitrogen: MA5-45166, MA1-164, MA5-45167, MA5-45168
StressMarq Biosciences: SMC-140
Novus Biologicals: NB100-1952-100ug
OriGene: TA326567

reactivity :

rat

product information

CATALOG NUMBER :

56270

PRODUCT NAME :

Anti-LAMP1 Antibody

NAME+SKU :

Anti-LAMP1 Antibody (56270)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-LAMP1 Antibody Mouse Monoclonal Antibody

SPECIFICITY SHORT :

LAMP1 Antibody

SPECIES REACTIVITY :

Rat, hamster

TARGET NAME :

LAMP1

UNIPROT :

P14562

LOCATION :

Cell membrane , Endosome membrane , Lysosome membrane , Late endosome membrane , Cytolytic granule membrane

PROTEIN NAME :

Lysosome-associated membrane glycoprotein 1

ALTERNATIVE NAMES :

LAMP-1, Lysosome-associated membrane protein 1, 120 kDa lysosomal membrane glycoprotein, LGP-120, CD107 antigen-like family member A, CD antigen CD107a

GENE NAME :

Lamp1

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

305.2

SKU SIZE 1 :

56270

APPLICATIONS :

WB, ICC

APPLICATION INSTRUCTIONS :

Immunoblotting: Use at 1ug/ml. A band of ~120kDa is detected. Immunocytochemistry: Use at 5-10ug/ml. These are recommended concentrations. Enduser should determine optimal concentrations for their application.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

Ly1C6

IMMUNOGEN :

Rat liver lysosome membranes.

RESEARCH AREA :

Cell adhesion

FORMULATION :

PBS, pH 7.4.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

TARGET BACKGROUND :

Lysosome-associated membrane proteins (LAMP1 and LAMP2) are major constituents of the lysosomal membrane. The structures of these two proteins are closely related with 37% sequence homology. Both are transmembrane glycoproteins localized primarily in lysosomes and late endosomes. Cell surface LAMP1 and LAMP2 promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium which suggests that they are involved in adhesion of PBMC at sites of inflammation.

FUNCTION :

Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity). Plays also an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis (By similarity). {UniProtKB:P11279, UniProtKB:P11438}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for at least one (1) year at -20C. Avoid multiple freeze-thaw cycles.

SPECIFICITY :

This antibody recognizes human, rat, and hamster LAMP1.Accession no.: NP_036989.1 Gene ID: 25328

Image Name_1 :

qed-bioscience-anti-lamp1-antibody--56270-1.png

Applications 1 :

ICC

Image Name_2 :

qed-bioscience-anti-lamp1-antibody--56270-2.png

Applications 2 :

Western Blot