This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
QED Bioscience
product type :
antibody
product name :
Anti-JAB-1 Antibody
catalog :
56210
quantity :
100 ug
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
8H8.5

The same clone is also sold as:
reactivity :
human, mouse
product information
CATALOG NUMBER :
56210
PRODUCT NAME :
Anti-JAB-1 Antibody
NAME+SKU :
Anti-JAB-1 Antibody (56210)
PRODUCT _TYPE :
Antibody
DESCRIPTION :
Anti-JAB-1 Mouse Monoclonal Antibody
SPECIFICITY SHORT :
JAB-1
SPECIES REACTIVITY :
Human, mouse
TARGET NAME :
JAB-1
UNIPROT :
Q92905
LOCATION :
Cytoplasm, cytosol , Nucleus , Cytoplasm, perinuclear region , Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
PROTEIN NAME :
COP9 signalosome complex subunit 5
ALTERNATIVE NAMES :
SGN5, Signalosome subunit 5, EC 3.4.-.-, Jun activation domain-binding protein 1
GENE NAME :
COPS5
CLONALITY :
Monoclonal
FORM :
Liquid
CONCENTRATION :
Lot Specific
SIZE 1 :
100 ug
DISTIRBUTOR PRICE :
322.7
SKU SIZE 1 :
56210
APPLICATIONS :
WB, IP
APPLICATION INSTRUCTIONS :
Immunoblotting and Immunoprecipitation: use at 0.5-1 ug/ml. Positive controls: 293 cells and recombinant fusion protein.
HOST :
Mouse
FORMAT :
Purified
PURIFICATION :
Purified by immunoaffinity chromatography
ISOTYPE :
IgG2a
CLONE ID :
8H8.5
IMMUNOGEN :
Mouse JAB-1 gst-fusion protein (aa 1-334) expressed in E. coli.
RESEARCH AREA :
Neuroscience
FORMULATION :
PBS, pH 7.4.
BUFFER :
Phosphate Buffered Saline
BUFFER PH :
pH 7.4
TARGET BACKGROUND :
JAB-1 is a 38 kD protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the “signalosome” which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants which plays an important role in light-mediated plant development. Although the specific function of JAB-1 is unclear, it appears to be involved in targeting proteins for degradation by the proteasome.
FUNCTION :
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. {PubMed:11285227, PubMed:11337588, PubMed:12628923, PubMed:12732143, PubMed:19214193, PubMed:20978819, PubMed:22609399, PubMed:9535219}.
DILUTION INSTRUCTIONS :
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE CONDITION :
This antibody is stable for at least one (1) year at -20C. Avoid multiple freeze- thaw cycles.
SPECIFICITY :
This antibody recognizes human and mouse JAB-1.
Image Name_1 :
qed-bioscience-anti-jab-1-antibody-56210-1.jpg
Applications 1 :
WB
Image Name_2 :
qed-bioscience-anti-jab-1-antibody-56210-2.jpg
Applications 2 :
WB
Image Name_3 :
qed-bioscience-anti-jab-1-antibody-56210-3.jpg
Applications 3 :
IP
company information
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com
800-929-2114 858-675-2405
headquarters: United States