Anti-Insulin receptor (beta subunit) Antibody | QED Bioscience 50104 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Insulin receptor (beta subunit) Antibody

catalog :

50104

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

18-44

The same clone is also sold as:

Invitrogen: MA1-10865
Abcam: ab983

reactivity :

human

product information

CATALOG NUMBER :

50104

PRODUCT NAME :

Anti-Insulin receptor (beta subunit) Antibody

NAME+SKU :

Anti-Insulin receptor (beta subunit) Antibody (50104)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Insulin receptor Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Insulin receptor

SPECIES REACTIVITY :

Human

TARGET NAME :

Insulin receptor (beta subunit)

UNIPROT :

P06213

LOCATION :

Cell membrane , Late endosome , Lysosome

PROTEIN NAME :

Insulin receptor

ALTERNATIVE NAMES :

IR, EC 2.7.10.1, CD antigen CD220 [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]

GENE NAME :

INSR

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

351.4

SKU SIZE 1 :

50104

APPLICATIONS :

WB, IP, partially inhibits insulin binding, stimulates lipogenesis, activates receptor kinase

HOST :

Mouse

FORMAT :

Purified

ISOTYPE :

IgG2b

CLONE ID :

18-44

IMMUNOGEN :

Human placental insulin receptor

RESEARCH AREA :

Growth Factors, Cytokines, Receptors

FORMULATION :

PBS, pH 7.4.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

FUNCTION :

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically rUniProtKB:P15208, PubMed:12138094, PubMed:16314505, PubMed:16831875, PubMed:8257688, PubMed:8276809, PubMed:8452530, PubMed:9428692}.

STORAGE CONDITION :

This antibody is stable for 1 month at 4°C or one year at -20°C. Avoid multiple freeze-thaw cycles.

SPECIFICITY :

All four clones recognize human insulin receptor; low-level cross-reactivity with bovine and rabbit insulin receptor.

Image Name_1 :

qed-bioscience-anti-insulin-receptor-alpha-subunit-antibody-50104-1.jpg

Applications 1 :