Anti-Interleukin-1 Receptor (IL-1R) Antibody | QED Bioscience 40103 product information

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product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Interleukin-1 Receptor (IL-1R) Antibody

catalog :

40103

quantity :

200 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

IL1-31-113.1.1

reactivity :

human

product information

CATALOG NUMBER :

40103

PRODUCT NAME :

Anti-Interleukin-1 Receptor (IL-1R) Antibody

NAME+SKU :

Anti-Interleukin-1 Receptor (IL-1R) Antibody (40103)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Interleukin-1 receptor Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Interleukin-1 receptor

SPECIES REACTIVITY :

Human

TARGET NAME :

Interleukin-1 Receptor (IL-1R)

UNIPROT :

P14778

LOCATION :

Membrane , Cell membrane , Secreted

PROTEIN NAME :

Interleukin-1 receptor type 1

ALTERNATIVE NAMES :

IL-1R-1, IL-1RT-1, IL-1RT1, EC 3.2.2.6, CD121 antigen-like family member A, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type I, p80, CD antigen CD121a [Cleaved into: Interleukin-1 receptor type 1, membrane form

GENE NAME :

IL1R1

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

200 ug

DISTIRBUTOR PRICE :

260.4

SKU SIZE 1 :

40103

APPLICATIONS :

ELISA, IHC, RIA

APPLICATION INSTRUCTIONS :

ELISA: Can be used as capture reagents or second antibody at a concentration of 5 ug/ml. RIA: Concentrations of 20-30 ng/ml of these antibodies will bind radiolabeled IL-1 receptor in a radioimmunoassay format. Immunohistochemistry: IL-1 receptor can be detected on cultured cells using antibody concentrations of 10-100 ug/ml.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by Protein G affinity chromatography.

ISOTYPE :

IgG2b

CLONE ID :

IL1-31-113.1.1

IMMUNOGEN :

The extracellular domain of the type I human IL-1 receptor (Genzyme Diagnostics).

RESEARCH AREA :

Growth Factors, Cytokines, Receptors

FORMULATION :

PBS, pH 7.4

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

FUNCTION :

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850). {PubMed:10653850, PubMed:10671496}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

These antibodies are stable for at leastone (1) year at -20 C to -70 C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

SPECIFICITY :

These antibodies react with cell surface and soluble human IL-1 receptor; Specific epitopes are unknown, but they do partially inhibit (30-50%) binding of one another to IL-1 receptor. They do not block binding of IL-1 to receptor, and they do not cross-react with receptors for human IL-2 or IL-4.