Anti-Ski Antibody | QED Bioscience 34021 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Ski Antibody

catalog :

34021

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

G8

The same clone is also sold as:

Santa Cruz Biotechnology: sc-33693 X, sc-33693 AC, sc-33693 HRP, sc-33693

reactivity :

human, mouse, rat, chicken

product information

CATALOG NUMBER :

34021

PRODUCT NAME :

Anti-Ski Antibody

NAME+SKU :

Anti-Ski Antibody (34021)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-SKI Mouse Monoclonal Antibody

SPECIFICITY SHORT :

SKI

SPECIES REACTIVITY :

Human, mouse, rat, chicken, Xenopus

TARGET NAME :

Ski

UNIPROT :

P12755

LOCATION :

Nucleus.

PROTEIN NAME :

Ski oncogene

ALTERNATIVE NAMES :

Proto-oncogene c-Ski

GENE NAME :

SKI

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

289.1

SKU SIZE 1 :

34021

APPLICATIONS :

WB, IF, IP

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-5 ug/ml. Predicted molecular weight of v-ski is 55 kDa; full-length ski ranges from ~95 kDa up to ~115 kDa for hyperphosphorylated ski. Immunocytochemistry: use at 1-10 ug/ml. ski is a nuclear protein. Immunoprecipitation: use at 1-5 ug/ml. Positive controls: Recombinant cell lines expressing ski proteins.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by Protein G affinity chromatography.

ISOTYPE :

IgG1

CLONE ID :

IMMUNOGEN :

Recombinant v-ski

RESEARCH AREA :

Cancer research

FORMULATION :

PBS, pH 7.4

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

TARGET BACKGROUND :

The ski oncogene family (ski and sno) encodes transcriptional regulators that can affect oncogenic transformation and cellular differenti- ation. ski and sno function as co- activators or co-repressors, modulating transcription by inter- acting with transcription factor complexes. ski interacts with members of the Nuclear Factor I (NFI) family, the retinoic acid receptor, and the nuclear hormone co-regulators NCoR and NCoA62/skip.

FUNCTION :

May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. {PubMed:19049980}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for at least one (1) year at -20C. Avoid multiple freeze- thaw cycles.

SPECIFICITY :

This antibody recognizes ski protein of human, mouse, rat, chicken, and Xenopus.