Anti-Thymidine kinase Antibody | QED Bioscience 34003 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Thymidine kinase Antibody

catalog :

34003

quantity :

200 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3B3.E11

The same clone is also sold as:

Santa Cruz Biotechnology: sc-56967
Invitrogen: MA1-21542

reactivity :

human

product information

CATALOG NUMBER :

34003

PRODUCT NAME :

Anti-Thymidine kinase Antibody

NAME+SKU :

Anti-Thymidine kinase Antibody (34003)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Thymidine Kinase Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Thymidine Kinase

SPECIES REACTIVITY :

Human

TARGET NAME :

Thymidine kinase

UNIPROT :

P04183

LOCATION :

Cytoplasm

PROTEIN NAME :

Thymidine kinase, cytosolic

ALTERNATIVE NAMES :

EC 2.7.1.21

GENE NAME :

TK1

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

200 ug

DISTIRBUTOR PRICE :

319.9

SKU SIZE 1 :

34003

APPLICATIONS :

WB, ELISA

APPLICATION INSTRUCTIONS :

Immunoblotting: antibody at 10 ug/ml will recognize TK in 5, 10, or 20 ug lysates of cells that express TK. ELISA: use antibody at 2-5 ug/ml (optimized for TK on solid phase at 10 ug/ml).

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by Protein G affinity chromatography.

ISOTYPE :

IgG1

CLONE ID :

3B3.E11

IMMUNOGEN :

5â€™-His-tagged recombinant human thymidine kinase.

RESEARCH AREA :

Cancer research

FORMULATION :

PBS, pH 7.4.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

TARGET BACKGROUND :

Thymidine kinase (TK) belongs to a group of enzymes such as dihydrofolate reductase, thymidylate synthase, and DNA polymerase that are involved in DNA synthesis and precursor production. High levels of these enzymes are present in proliferating cells, and low levels are found in resting cells, due to multiple regulatory mechanisms that ensure exclusive expression of these enzymes in replicating cells. TK is responsible for catalyzing the phosphorylation of thymidine, which functions as a part of the pyrimidine salvage pathway involved in DNA synthesis. The activities of enzymes such as TK are essential for the activation of several chemotherapeutically important nucleoside analogues that are administered as prodrugs.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for at least one (1) year at -20C. Avoid multiple freeze- thaw cycles.

SPECIFICITY :

This antibody specifically recognizes human thymidine kinase.