Anti-Progesterone Receptor Antibody | QED Bioscience 3341 product information

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product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Progesterone Receptor Antibody

catalog :

3341

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4D8

reactivity :

human

product information

CATALOG NUMBER :

3341

PRODUCT NAME :

Anti-Progesterone Receptor Antibody

NAME+SKU :

Anti-Progesterone Receptor Antibody (3341)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Progesterone Receptor Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Progesterone Receptor

SPECIES REACTIVITY :

Human

TARGET NAME :

Progesterone Receptor

UNIPROT :

P06401

LOCATION :

Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.; [Isoform A]: Nucleus. Cytoplasm. Note=Mainly nuclear.; [Isoform 4]: Mitochondrion outer membrane

PROTEIN NAME :

Progesterone receptor

ALTERNATIVE NAMES :

PR, Nuclear receptor subfamily 3 group C member 3

GENE NAME :

PGR

ACCESSION NUMBER :

NP_000917

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

322.7

SKU SIZE 1 :

3341

APPLICATIONS :

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-5 ug/ml. Positive controls: MCF7 cells or recombinant protein.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by Protein G affinity chromatography.

ISOTYPE :

IgG2a

CLONE ID :

4D8

IMMUNOGEN :

6-His fusion protein containing the region encoding aa 1-101 of human progesterone receptor expressed in E. coli.

RESEARCH AREA :

Cancer Research

FORMULATION :

PBS, pH 7.4

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

FUNCTION :

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor. {PubMed:10757795, PubMed:1587864, PubMed:9407067, PubMed:7969170, PubMed:8180103, PubMed:8264658, PubMed:10757795}.; [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {PubMed:7969170}.; [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for 1 month at 4°C or one year at -20°C. Avoid multiple freeze-thaw cycles.

SPECIFICITY :

This antibody recognizes human progesterone receptor (PgR), a member of the steroid family of nuclear receptors. PgR is found as a 94 kD protein (Form A) or a 120 kD protein (Form B). Binding of progesterone to its receptor results in a conformational change that allows dimerization and binding of the receptor to progesterone response elements and activated transcription. When bound to DNA, PgR can positively or negatively regulate gene transcription.