Anti-Heme Oxygenase-1 Antibody | QED Bioscience 13060 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Heme Oxygenase-1 Antibody

catalog :

13060

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

GTS-1

The same clone is also sold as:

Invitrogen: MA1-25475

reactivity :

human, mouse, rat

product information

CATALOG NUMBER :

13060

PRODUCT NAME :

Anti-Heme Oxygenase-1 Antibody

NAME+SKU :

Anti-Heme Oxygenase-1 Antibody (13060)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Heme Oxygenase-1 Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Heme Oxygenase-1

SPECIES REACTIVITY :

Human, mouse, rat

TARGET NAME :

Heme Oxygenase-1

UNIPROT :

P09601

LOCATION :

Microsome , Endoplasmic reticulum membrane , Peripheral membrane protein , Cytoplasmic side

PROTEIN NAME :

Heme oxygenase 1

ALTERNATIVE NAMES :

HO-1, EC 1.14.14.18

GENE NAME :

HMOX1

ACCESSION NUMBER :

NP_002124

CLONALITY :

Monoclonal

FORM :

Lyophilized

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

356.3

SKU SIZE 1 :

13060

APPLICATIONS :

WB, ELISA, IHC, Neutralization

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 5-10ug/ml. A band of ~33kDa is detected. Immunohistochemistry: use at 5-10ug/ml on human frozen or paraffin-embedded tissue. Antigen retrieval with 0.4ug/ml Proteinase K. These are recommended concentrations. Endusers should determine optimal concentrations for their applications.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

GTS-1

IMMUNOGEN :

Microsomal fraction of transformed mouse T-cell transfected with rat heme oxygenase- 1 (WR19LrHO-1).

RESEARCH AREA :

Enzymes

FORMULATION :

PBS, pH 7.4, 1% BSA., lyophilized.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER PROTEIN STABILIZER :

1% Bovine Serum Albumin

TARGET BACKGROUND :

Heme-oxygenase is an enzyme that catalyzes heme catabolism to yield biliverdin, iron, and carbon monoxide (CO). There are three isoforms of heme-oxygenase: HO-1, HO-2, and HO-3. HO-1 and HO-2 have been identified as the two major isoforms in mammals. HO-1, also known as heat shock protein 32 (Hsp32) is induced by most oxidative stress inducers, cytokines, inflammatory agents, and heat shock. HO-1 deficiency appears to cause reduced stress defense, a pro-inflammatory tendency, susceptibility to atherosclerotic lesion formation, endothelial cell injury, and growth retardation. Therefore, up-regulation of HO-1 is one of the major defense mechanisms against oxidative stress.

FUNCTION :

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.

STORAGE CONDITION :

This antibody is stable at 2 â€“ 8C for one (1) year from date of receipt.

SPECIFICITY :

This antibody recognizes human, rat, and mouse HO-1. It does not recognize rabbit HO-1 and does not cross-react with HO-2.

Image Name_1 :

qed-bioscience-anti-heme-oxygenase-1-antibody-13060-1.jpg

Applications 1 :

Image Name_2 :

qed-bioscience-anti-heme-oxygenase-1-antibody-13060-2.jpg

Applications 2 :

IHC