Anti-ASIC1 Antibody | QED Bioscience 11573 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-ASIC1 Antibody

catalog :

11573

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S271-44

The same clone is also sold as:

OriGene: TA326467
Abcam: ab240896
Novus Biologicals: NBP2-22409

reactivity :

mouse, rat

product information

CATALOG NUMBER :

11573

PRODUCT NAME :

Anti-ASIC1 Antibody

NAME+SKU :

Anti-ASIC1 Antibody (11573)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-AISC1 Mouse Monoclonal Antibody

SPECIFICITY SHORT :

AISC1

SPECIES REACTIVITY :

Mouse, rat

TARGET NAME :

ASIC1

UNIPROT :

Q6NXK8

LOCATION :

Cell membrane

PROTEIN NAME :

Acid-sensing ion channel 1

ALTERNATIVE NAMES :

ASIC1, Acid-sensing ion channel, Amiloride-sensitive cation channel 2, neuronal, Brain sodium channel 2, BNaC2

GENE NAME :

Asic1

ACCESSION NUMBER :

NP_033727.1

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

305.2

SKU SIZE 1 :

11573

APPLICATIONS :

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1ug/ml. A band of ~60kDa is detected. Positive control: Rat brain lysate. These are recommended concentrations. User should determine optimal concentrations for their application.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

S271-44

IMMUNOGEN :

Fusion protein corresponding to aa 460-526 (cytoplasmic C-terminus) of mouse ASIC1 (accession no. Q6NXK8).

RESEARCH AREA :

Ion Channels

FORMULATION :

PBS, pH 7.4; 50% glycerol, 0.09% sodium azide.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER ANTI-MICROBIAL :

0.09% Sodium Azide

BUFFER CRYOPRESERVATIVE :

50% Glycerol

TARGET BACKGROUND :

Acid sensing (proton-gated) ion channel 1 (ASIC1) is a cation channel with high affinity for sodium which is gated by extracellular protons and inhibited by the diuretic amiloride. It is also permeable for Ca(2+), Li(+) and K(+) and mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. ASIC1 functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin- dependent protein kinase II phosphory- lation.

FUNCTION :

Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then bPubMed:11988176, PubMed:12843249, PubMed:15369669, PubMed:15578512, PubMed:17060608, PubMed:17662962}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for at least one (1) year at -20C. Avoid repeated freezing and thawing.

SPECIFICITY :

This antibody recognizes mouse and rat ASIC1. It does not cross-react with ASIC2.

Image Name_1 :

qed-bioscience-anti-asic1-antibody-11573-1.png

Applications 1 :

ICC

Image Name_2 :

qed-bioscience-anti-asic1-antibody-11573-2.png

Applications 2 :

Western Blot

Image Name_3 :

qed-bioscience-anti-asic1-antibody-11573-3.png

Applications 3 :

ICC