Anti-SUR2A Antibody | QED Bioscience 11570 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-SUR2A Antibody

catalog :

11570

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S319A-14

The same clone is also sold as:

OriGene: TA326461
Novus Biologicals: NBP2-22403

reactivity :

mouse, rat

product information

CATALOG NUMBER :

11570

PRODUCT NAME :

Anti-SUR2A Antibody

NAME+SKU :

Anti-SUR2A Antibody (11570)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-SUR2A Mouse Monoclonal Antibody

SPECIFICITY SHORT :

SUR2A

SPECIES REACTIVITY :

Mouse, rat

TARGET NAME :

SUR2A

UNIPROT :

P70170

LOCATION :

Membrane , Multi-pass membrane protein

PROTEIN NAME :

ATP-binding cassette sub-family C member 9

ALTERNATIVE NAMES :

Sulfonylurea receptor 2

GENE NAME :

Abcc9

ACCESSION NUMBER :

NP_001038185.1

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

305.2

SKU SIZE 1 :

11570

APPLICATIONS :

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-2ug/ml. A band of ~120kDa is detected. Positive control: Mouse brain lysate. These are recommended concentrations. User should determine optimal concentrations for their application.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG2a

CLONE ID :

S319A-14

IMMUNOGEN :

Fusion protein corresponding to aa 1505-1546 (SSIVDAGLVLVFSEGILVECDTGPNLLQ HKNGLFSTLVMTNK, cytoplasmic C- terminus) of mouse SUR2A (accession no. P70170).

RESEARCH AREA :

Ion Channels

FORMULATION :

PBS, pH 7.4; 50% glycerol, 0.09% sodium azide.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER ANTI-MICROBIAL :

0.09% Sodium Azide

BUFFER CRYOPRESERVATIVE :

50% Glycerol

TARGET BACKGROUND :

Sulfonylurea receptors (SUR) are membrane proteins that are molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the SUR is to sense intracellular levels of ATP and ADP and facilitate the opening or closing of its associated Kir6.x potassium channel, thus monitoring the energy balance within cells.

FUNCTION :

Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for at least one (1) year at -20C. Avoid repeated freeze- thaw cycles.

SPECIFICITY :

This antibody recognizes mouse and rat SUR2A. It does not cross-react with SUR2B.

Image Name_1 :

qed-bioscience-anti-sur2a-antibody-11570-1.png

Applications 1 :

ICC

Image Name_2 :

qed-bioscience-anti-sur2a-antibody-11570-2.png

Applications 2 :

Western Blot

Image Name_3 :

qed-bioscience-anti-sur2a-antibody-11570-3.png

Applications 3 :

ICC