Anti-SUR1 Antibody | QED Bioscience 11567 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-SUR1 Antibody

catalog :

11567

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S289-16

The same clone is also sold as:

OriGene: TA326508
Novus Biologicals: NBP2-59320

reactivity :

human, mouse, rat

product information

CATALOG NUMBER :

11567

PRODUCT NAME :

Anti-SUR1 Antibody

NAME+SKU :

Anti-SUR1 Antibody (11567)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-SUR1 Mouse Monoclonal Antibody

SPECIFICITY SHORT :

SUR1

SPECIES REACTIVITY :

Human, mouse, rat

TARGET NAME :

SUR1

UNIPROT :

Q09429

LOCATION :

Cell membrane , Multi-pass membrane protein

PROTEIN NAME :

ATP-binding cassette sub-family C member 8

ALTERNATIVE NAMES :

Sulfonylurea receptor 1

GENE NAME :

Abcc8

ACCESSION NUMBER :

NP_037171.2

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

305.2

SKU SIZE 1 :

11567

APPLICATIONS :

WB, IHC

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-2ug/ml. A band of ~160kDa is detected. Immunohistochemistry: use at 1-10ug/ml. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Mouse brain membranes.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

S289-16

IMMUNOGEN :

Fusion protein corresponding to aa 1548-1582 (cytoplasmic C-terminus) of rat SUR1 (accession no. NP_037171.2).

RESEARCH AREA :

Ion Channels

FORMULATION :

PBS, pH 7.4; 50% glycerol, 0.09% sodium azide.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER ANTI-MICROBIAL :

0.09% Sodium Azide

BUFFER CRYOPRESERVATIVE :

50% Glycerol

TARGET BACKGROUND :

Sulfonylurea receptors (SUR) are membrane proteins that are molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the SUR is to sense intracellular levels of ATP and ADP and facilitate the opening or closing of its associatedKir6.x potassium channel, thus monitoring the energy balance within cells.

FUNCTION :

Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. {UniProtKB:Q09428}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for at least one (1) year at -20C. Avoid repeated freezing and thawing.

SPECIFICITY :

This antibody recognizes human, mouse, and rat SUR1. It does not cross-react with SUR2B.

Image Name_1 :

qed-bioscience-anti-sur1-antibody-11567-1.png

Applications 1 :

ICC

Image Name_2 :

qed-bioscience-anti-sur1-antibody-11567-2.png

Applications 2 :

ICC

Image Name_3 :

qed-bioscience-anti-sur1-antibody-11567-3.png

Applications 3 :

Western Blot