Anti-Cav3.2 Ca+2 Channel Antibody | QED Bioscience 11505 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Cav3.2 Ca+2 Channel Antibody

catalog :

11505

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S55-10

The same clone is also sold as:

Rockland Immunochemicals: 200-301-F11
Novus Biologicals: NBP1-22444
OriGene: TA309309

reactivity :

human, mouse, rat

product information

CATALOG NUMBER :

11505

PRODUCT NAME :

Anti-Cav3.2 Ca+2 Channel Antibody

NAME+SKU :

Anti-Cav3.2 Ca+2 Channel Antibody (11505)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Cav3.2 Ca +2 Channel Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Cav3.2 Ca +2 Channel

SPECIES REACTIVITY :

Human, mouse, rat

TARGET NAME :

Cav3.2 Ca+2 Channel

UNIPROT :

O95180

LOCATION :

Cell membrane

PROTEIN NAME :

Voltage-dependent T-type calcium channel subunit alpha-1H

ALTERNATIVE NAMES :

Low-voltage-activated calcium channel alpha1 3.2 subunit, Voltage-gated calcium channel subunit alpha Cav3.2

GENE NAME :

CACNA1H

ACCESSION NUMBER :

NP_001005407.1

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

305.2

SKU SIZE 1 :

11505

APPLICATIONS :

WB, IHC, ICC, IF

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-10ug/ml. A band of >260kDa is detected. Immunohistochemistry and and immunocytochemistry: use at 0.1-1ug/ml. Immunofluorescence: use at 1-10ug/ml. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain membranes.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

S55-10

IMMUNOGEN :

Fusion protein corresponding to aa 1019-1293 (II-III loop)

RESEARCH AREA :

Ion Channels

FORMULATION :

PBS, pH 7.4; 50% glycerol, 0.09% sodium azide.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER ANTI-MICROBIAL :

0.09% Sodium Azide

BUFFER CRYOPRESERVATIVE :

50% Glycerol

TARGET BACKGROUND :

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Cav3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest that certain mutations in this gene lead to childhood absence epilepsy. It has also been suggested that up-regulation of Cav3.2 may be involved in the progression of prostate cancer toward an androgen -independent stage.

FUNCTION :

Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:9670923, PubMed:9930755, PubMed:27149520). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). {PubMed:24277868, PubMed:25907736, PubMed:27149520, PubMed:27729216, PubMed:9670923, PubMed:9930755, PubMed:15048902}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for at least one (1) year at -20C. Avoid repeated freeze-thaw cycles.

SPECIFICITY :

This antibody recognizes human, mouse, and rat Cav3.2. It does not cross-react with Cav1.3.

Image Name_1 :

qed-bioscience-anti-cav3.2-ca+2-channel-antibody-11505-1.png

Applications 1 :

ICC

Image Name_2 :

qed-bioscience-anti-cav3.2-ca+2-channel-antibody-11505-2.png

Applications 2 :

IHC

Image Name_3 :

qed-bioscience-anti-cav3.2-ca+2-channel-antibody-11505-3.png

Applications 3 :

IHC