Anti-Aha1 Antibody | QED Bioscience 11140 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Aha1 Antibody

catalog :

11140

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4H9-D7

The same clone is also sold as:

OriGene: TA326390

reactivity :

human, mouse

product information

CATALOG NUMBER :

11140

PRODUCT NAME :

Anti-Aha1 Antibody

NAME+SKU :

Anti-Aha1 Antibody (11140)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Aha1 Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Aha1

SPECIES REACTIVITY :

Human, mouse

TARGET NAME :

Aha1

UNIPROT :

O95433

LOCATION :

Cytoplasm, cytosol , Endoplasmic reticulum

PROTEIN NAME :

Activator of 90 kDa heat shock protein ATPase homolog 1

ALTERNATIVE NAMES :

AHA1, p38

GENE NAME :

AHSA1

ACCESSION NUMBER :

NP_036243.1

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

1.0 mg/mL

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

242.9

SKU SIZE 1 :

11140

APPLICATIONS :

WB, ELISA

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1ug/ml. A band of ~38kDa is detected. Band can appear as high as 45kDa. ELISA: use at 1-10ug/ml with Aha1 on the solid phase. These are recommended concentrations; enduser should determine optimal concentrations for their applications.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

4H9-D7

IMMUNOGEN :

His-tagged recombinant human Aha1 (accession no. NP_036243.1)

RESEARCH AREA :

Heat Shock & Stress Proteins

FORMULATION :

PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

BUFFER ANTI-MICROBIAL :

0.09% Sodium Azide

BUFFER CRYOPRESERVATIVE :

50% Glycerol

TARGET BACKGROUND :

Aha1 is a member of the Hsp90 co- chaperone family that appears to stimulate Hsp90 ATPase activity by competing with p23 and other co- chaperones for Hsp90 binding. Aha1 also interacts with HSPCA/Hsp90 and with the cytoplasmic tail of the vesicular stomatitis virus glycoproteins (VSV-G). Aha 1 is expressed in numerous tissues including brain, heart, skeletal muscle, and kidney and is present at low levels in liver and placenta.

FUNCTION :

Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). {PubMed:27353360, PubMed:29127155}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for at least one (1) year at -20C. Avoid repeated freeze- thaw cycles.

SPECIFICITY :

This antibody recognizes human and mouse Aha1 and cross-reacts with mouse Aha2.

Image Name_1 :

qed-bioscience-anti-aha1-antibody-11140-1.jpg

Applications 1 :