This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
QED Bioscience
product type :
antibody
product name :
Anti-Hsp90 alpha Antibody
catalog :
11112
quantity :
100 ug
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2G5.G3

The same clone is also sold as:
reactivity :
human, mouse, rat
product information
CATALOG NUMBER :
11112
PRODUCT NAME :
Anti-Hsp90 alpha Antibody
NAME+SKU :
Anti-Hsp90 alpha Antibody (11112)
PRODUCT _TYPE :
Antibody
DESCRIPTION :
Anti-Hsp90 alpha Mouse Monoclonal Antibody
SPECIFICITY SHORT :
Hsp90 alpha
SPECIES REACTIVITY :
Human, mouse, rat
TARGET NAME :
Hsp90 alpha
UNIPROT :
P07900
LOCATION :
Nucleus , Cytoplasm , Melanosome , Cell membrane , Mitochondrion
PROTEIN NAME :
Heat shock protein HSP 90-alpha
ALTERNATIVE NAMES :
EC 3.6.4.10, Heat shock 86 kDa, HSP 86, HSP86, Lipopolysaccharide-associated protein 2, LAP-2, LPS-associated protein 2, Renal carcinoma antigen NY-REN-38
GENE NAME :
HSP90AA1
ACCESSION NUMBER :
NP_001017963.2
CLONALITY :
Monoclonal
FORM :
Liquid
CONCENTRATION :
Lot Specific
SIZE 1 :
100 ug
DISTIRBUTOR PRICE :
264.6
SKU SIZE 1 :
11112
APPLICATIONS :
WB, ELISA, IHC, IP
APPLICATION INSTRUCTIONS :
Immunoblotting: use at 0.5-1ug/ml. A band of ~90 kDa is detected. ELISA Immunohistochemistry/ Immuno- cytochemistry Imunoprecipitation User should determine optimal concentrations for their application. Positive control: HeLa cell lysate.
HOST :
Mouse
FORMAT :
Purified
PURIFICATION :
Purified by Protein G affinity chromatography.
ISOTYPE :
IgG1
CLONE ID :
2G5.G3
IMMUNOGEN :
Host Species: Mouse
RESEARCH AREA :
Heat Shock & Stress Proteins
FORMULATION :
PBS, pH 7.4.
BUFFER :
Phosphate Buffered Saline
BUFFER PH :
pH 7.4
TARGET BACKGROUND :
Hsp90 is an abundantly and ubiquitously expressed heat shock protein found in all eukaryotic cells. It exists in two principal forms, alpha and beta, which share 85% sequence homology. Both forms are expressed in the cytosol. Hsp90alpha exists primarily as a homodimer while Hsp90beta exists mainly as a monomer. Hsp90 plays a role in folding, assembly, maturation, and stabilization of specific proteins as a key component of a chaperone complex. Most of the Hsp90-regulated proteins that have been identified are involved in cell signaling; kinases, v-Src, Wee1, c-Raf, and p53 are some examples. When bound to ATP, Hsp90 interacts with co- chaperones Cdc37, p23, and various immunophilin-like proteins to form complexes that stabilize and protect target proteins from proteasomal degradation.
FUNCTION :
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate rPubMed:11274138, PubMed:11276205, PubMed:12526792, PubMed:15577939, PubMed:15937123, PubMed:20628368, PubMed:24613385, PubMed:25609812, PubMed:27353360, PubMed:29127155, PubMed:25973397, PubMed:26991466, PubMed:27295069}.
DILUTION INSTRUCTIONS :
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE CONDITION :
This antibody is stable for at least one (1) year at -20C. Avoid repeated freezing and thawing.
SPECIFICITY :
This antibody recognizes human, mouse, and rat Hsp90alpha. Other species have not been tested. It does not cross-react with Hsp90beta in ELISA.
company information
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com
800-929-2114 858-675-2405
headquarters: United States