Anti-Hsp90 alpha Antibody | QED Bioscience 11102 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Hsp90 alpha Antibody

catalog :

11102

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

D7alpha

reactivity :

human, mouse, rat, chicken, bovine

product information

CATALOG NUMBER :

11102

PRODUCT NAME :

Anti-Hsp90 alpha Antibody

NAME+SKU :

Anti-Hsp90 alpha Antibody (11102)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Hsp90alpha Mouse Monoclonal Antibody

SPECIFICITY SHORT :

Hsp90alpha

SPECIES REACTIVITY :

Human, mouse, rat, rabbit, bovine, porcine, chicken

TARGET NAME :

Hsp90 alpha

UNIPROT :

P11501

LOCATION :

Cytoplasm , Melanosome

PROTEIN NAME :

Heat shock protein HSP 90-alpha

GENE NAME :

HSP90AA1

ACCESSION NUMBER :

NP_001103255.1

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

313.6

SKU SIZE 1 :

11102

APPLICATIONS :

WB, IP

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 1-5ug/ml. A band of ~90 kDa is detected. Immunoprecipitation: 5ug on 20ul Protein A-Sepharose + 100ul sample. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Heat-shocked HeLa cell lysate.

HOST :

Mouse

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

D7alpha

IMMUNOGEN :

Full-length Hsp90 purified from chicken brain

RESEARCH AREA :

Heat Shock & Stress Proteins

FORMULATION :

PBS, pH 7.4.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

TARGET BACKGROUND :

Hsp90 and the 94 kDa glucose-regulated protein, Grp94, are major molecular chapeones of the cytosol and endoplasmic reticulum. In mammalian cells, there are at least two Hsp90 isoforms, Hsp90alpha and Hsp90beta, which are encoded by separate genes. All known members of the Hsp90 family are highly conserved, especially in the N-terminal and C-terminal regions. In the absence of stress, Hsp90 is an essential component of cellular processes such as hormone signaling and cell cycle control. Several regulatory proteins such as steroid receptors, cell cycle kinases and p53 have been identified as substrates of Hsp90.

FUNCTION :

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate rUniProtKB:P07900}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for at least one (1) year at -20C. Avoid repeated freezing and thawing.

SPECIFICITY :

This antibody recognizes human, mouse, rat, rabbit, bovine, porcine, and chicken Hsp90alpha (90 kDa).

Image Name_1 :

qed-bioscience-anti-hsp90-alpha-antibody-11102-1.png

Applications 1 :

IHC

Image Name_2 :

qed-bioscience-anti-hsp90-alpha-antibody-11102-2.png

Applications 2 :

IHC

Image Name_3 :

qed-bioscience-anti-hsp90-alpha-antibody-11102-3.png

Applications 3 :

Western Blot