Anti-Bcl-3 Antibody | QED Bioscience 11067 product information

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product summary

company name :

QED Bioscience

product type :

antibody

product name :

Anti-Bcl-3 Antibody

catalog :

11067

quantity :

100 ug

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

150-3.5

The same clone is also sold as:

Santa Cruz Biotechnology: sc-32741 HRP, sc-32741, sc-32741 AC

reactivity :

human, mouse

product information

CATALOG NUMBER :

11067

PRODUCT NAME :

Anti-Bcl-3 Antibody

NAME+SKU :

Anti-Bcl-3 Antibody (11067)

PRODUCT _TYPE :

Antibody

DESCRIPTION :

Anti-Bcl-3 Hamster Monoclonal Antibody

SPECIFICITY SHORT :

Bcl-3

SPECIES REACTIVITY :

Human, mouse

TARGET NAME :

Bcl-3

UNIPROT :

P20749

LOCATION :

Nucleus. Cytoplasm , Cytoplasm, perinuclear region

PROTEIN NAME :

B-cell lymphoma 3 protein

ALTERNATIVE NAMES :

BCL-3, Proto-oncogene BCL3

GENE NAME :

BCL3

ACCESSION NUMBER :

NP_005169

CLONALITY :

Monoclonal

FORM :

Liquid

CONCENTRATION :

Lot Specific

SIZE 1 :

100 ug

DISTIRBUTOR PRICE :

264.6

SKU SIZE 1 :

11067

APPLICATIONS :

WB, ELISA

APPLICATION INSTRUCTIONS :

Immunoblotting: use at 2ug/ml. A band of approx. 64kDa is detected. ELISA: Enduser should determine optimal concentration for each sample. Positive control: Jurkat T cell lysate. See Bassetti MFJ et al. 2009 International Immunology 21: 339-348.

HOST :

Hamster

FORMAT :

Purified

PURIFICATION :

Purified by immunoaffinity chromatography

ISOTYPE :

IgG1

CLONE ID :

150-3.5

IMMUNOGEN :

Recombinant mouse Bcl-3- 6His.

RESEARCH AREA :

Apoptosis

FORMULATION :

PBS, pH 7.4.

BUFFER :

Phosphate Buffered Saline

BUFFER PH :

pH 7.4

TARGET BACKGROUND :

The gene encoding Bcl-3 was first identified as the gene altered in some cases of chronic B cell lymphocytic leukemia and was later found to belong to the IkappaB subfamily of inhibitors of NFkappaB transcription factors. Bcl- 3 does not have DNA-binding activity, but it interacts with NFkappaB1 and NFkappaB2 which, when bound to DNA, repress gene transcription. Therefore, Bcl-3 may promote gene expression that is repressed by members of the NFkappaB family. Bcl-3 RNA is highly expressed in spleen and liver with lower levels of expression in heart, skeletal muscle, lung, kidney, and testes.

FUNCTION :

Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {PubMed:8453667}.

DILUTION INSTRUCTIONS :

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE CONDITION :

This antibody is stable for at least one (1) year at -20C. Avoid repeated freezing and thawing.

SPECIFICITY :

This antibody recognizes human and mouse Bcl-3.