| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry; human; loading ...; fig 6f
- western blot; human; 1:2000; loading ...; fig 4a
| Zhou Z, Zhou Q, Wu X, Xu S, Hu X, Tao X, et al. VCAM-1 secreted from cancer-associated fibroblasts enhances the growth and invasion of lung cancer cells through AKT and MAPK signaling. Cancer Lett. 2020;473:62-73 pubmed publisher |
- western blot; human; 1:5000; loading ...; fig 4a
| Luo C, Wang Y, Wei C, Chen Y, Ji Z. The anti-migration and anti-invasion effects of Bruceine D in human triple-negative breast cancer MDA-MB-231 cells. Exp Ther Med. 2020;19:273-279 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5f
| Jiang Z, Tang Y, Song H, Yang M, Li B, Ni C. miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6. Int J Mol Med. 2020;45:45-52 pubmed publisher |
- western blot; human; loading ...; fig 4e
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- western blot; human; loading ...; fig 8a
| Li N, Men W, Zheng Y, Wang H, Meng X. Oroxin B Induces Apoptosis by Down-Regulating MicroRNA-221 Resulting in the Inactivation of the PTEN/PI3K/AKT Pathway in Liver Cancer. Molecules. 2019;24: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1f
| Gao H, Zhang J, Ren X. PD-L1 regulates tumorigenesis and autophagy of ovarian cancer by activating mTORC signaling. Biosci Rep. 2019;39: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6a
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- immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 6a
- western blot; mouse; loading ...; fig 6b
- western blot; human; loading ...; fig 7a
| Zhang Y, Cao Y, Chen J, Qin H, Yang L. A New Possible Mechanism by Which Punicalagin Protects against Liver Injury Induced by Type 2 Diabetes Mellitus: Upregulation of Autophagy via the Akt/FoxO3a Signaling Pathway. J Agric Food Chem. 2019;: pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 5b
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- western blot; human; 1:2000; loading ...; fig 6c
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- western blot; human; 1:1000; loading ...; fig s4
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- western blot; human; 1:1000; loading ...; fig 2g
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- western blot; human; 1:1000; loading ...; fig 2a
| Wang K, Zhu T, Zhao R. Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration. Mol Med Rep. 2019;20:3671-3678 pubmed publisher |
- western blot; human; 1:2000; loading ...; fig 6b
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- western blot; rat; 1:1000; loading ...; fig 8c
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- western blot; human; 1:2000; loading ...; fig 6a
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- western blot; human; loading ...; fig 6a
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- immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 6m
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- western blot; human; 1:500; loading ...; fig 6a
| Liu B, Zhang J, Yang D. miR-96-5p promotes the proliferation and migration of ovarian cancer cells by suppressing Caveolae1. J Ovarian Res. 2019;12:57 pubmed publisher |
- western blot; rat; 1:1000; loading ...; fig 6a
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- western blot; mouse; loading ...; fig 2c
- western blot; human; loading ...; fig 4c
| Xu F, Xiao H, Liu R, Yang Y, Zhang M, Chen L, et al. Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt. Front Pharmacol. 2019;10:261 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6c
- western blot; hamsters; 1:1000; loading ...; fig 6c
| Wu Y, Tan X, Liu P, Yang Y, Huang Y, Liu X, et al. ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways. Exp Cell Res. 2019;379:30-47 pubmed publisher |
- western blot; human; loading ...; fig 6e
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- western blot; human; 1:1000; loading ...; fig 5a
| Li L, Liu M, Zhang Z, Zhang W, Liu N, Sheng X, et al. Derlin1 functions as an oncogene in cervical cancer via AKT/mTOR signaling pathway. Biol Res. 2019;52:8 pubmed publisher |
- western blot; mouse; fig s1
| Yang Z, Huang C, Wu Y, Chen B, Zhang W, Zhang J. Autophagy Protects the Blood-Brain Barrier Through Regulating the Dynamic of Claudin-5 in Short-Term Starvation. Front Physiol. 2019;10:2 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4e
| Jia Y, Qi Y, Wang Y, Ma X, Xu Y, Wang J, et al. Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway. Cancer Cell Int. 2019;19:9 pubmed publisher |
- western blot; human; loading ...; fig 2a
| Chen L, Yang G, Dong H. Everolimus Reverses Palbociclib Resistance in ER+ Human Breast Cancer Cells by Inhibiting Phosphatidylinositol 3-Kinase(PI3K)/Akt/Mammalian Target of Rapamycin (mTOR) Pathway. Med Sci Monit. 2019;25:77-86 pubmed publisher |
- immunocytochemistry; human; 1:1000; loading ...; fig 4a
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| Yuan X, Zhang L, Cui Y, Yu Y, Gao X, Ao J. NCOA5 is a master regulator of amino acid-induced mTOR activation and β-casein synthesis in bovine mammary epithelial cells. Biochem Biophys Res Commun. 2020;529:569-574 pubmed publisher |
| Guo Q, Wang T, Yang Y, Gao L, Zhao Q, Zhang W, et al. Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity. Mol Ther Nucleic Acids. 2020;21:527-541 pubmed publisher |
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| Ji H, Zhang X. RPL38 Regulates the Proliferation and Apoptosis of Gastric Cancer via miR-374b-5p/VEGF Signal Pathway. Onco Targets Ther. 2020;13:6131-6141 pubmed publisher |
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| Tian R, Jiang H, Shao L, Yu Y, Guo Q, Cao B, et al. miR193b Promotes Apoptosis of Gastric Cancer Cells via Directly Mediating the Akt Pathway. Biomed Res Int. 2020;2020:2863236 pubmed publisher |
| Zhang Y, Chen L, Cao Y, Chen S, Xu C, Xing J, et al. LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway. J Gastric Cancer. 2020;20:139-151 pubmed publisher |
| Wu Y, Wang Z, Fu X, Lin Z, Yu K. Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies. Int Immunopharmacol. 2020;86:106713 pubmed publisher |
| An L, Zhao J, Sun X, Zhou Y, Zhao Z. S-allylmercaptocysteine inhibits mucin overexpression and inflammation via MAPKs and PI3K-Akt signaling pathways in acute respiratory distress syndrome. Pharmacol Res. 2020;159:105032 pubmed publisher |
| Liu J, Shangguan Y, Sun J, Cong W, Xie Y. BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways. Biomed Pharmacother. 2020;129:110414 pubmed publisher |
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| Yan S, Yue Y, Sun M, Wu B, Wang X. Suppressive effect of Aurantii Fructus Immaturus and Atractylodis Macrocephalae Rhizoma on glutamic acid-induced autophagy of interstitial cells of Cajal. J Integr Med. 2020;18:334-343 pubmed publisher |
| Dai H, Li M, Yang W, Sun X, Wang P, Wang X, et al. Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling. Aging (Albany NY). 2020;12:11717-11731 pubmed publisher |
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| Han B, Jiang L, Jiang P, Zhou D, Jia X, Li X, et al. Daucosterol linolenate from Sweet Potato Suppresses MCF7-Xenograft-Tumor Growth through Regulating PI3K/AKT Pathway. Planta Med. 2020;86:767-775 pubmed publisher |
| Liu Y, Yang C, Feng X, Qi L, Guo J, Zhu D, et al. Prenatal High-Salt Diet-Induced Metabolic Disorders via Decreasing Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α in Adult Male Rat Offspring. Mol Nutr Food Res. 2020;64:e2000196 pubmed publisher |
| Liu Y, Tsai J, Weng Y, Hsu F. Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer. Biomed Pharmacother. 2020;128:110319 pubmed publisher |
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| Li P, Ding L, Cao S, Feng X, Zhang Q, Chen Y, et al. Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells. J Ethnopharmacol. 2020;259:113015 pubmed publisher |
| Wu G, Long Y, Lu Y, Feng Y, Yang X, Xu X, et al. Kindlin‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction. Oncol Rep. 2020;44:69-76 pubmed publisher |
| Wang L, Lv Y, Liu G. The roles of SHANK1 in the development of colon cancer. Cell Biochem Funct. 2020;: pubmed publisher |
| Meng X, Zhang C, Guo Y, Han Y, Wang C, Chu H, et al. TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways. Oxid Med Cell Longev. 2020;2020:8787156 pubmed publisher |
| Li J, Ma J, Tian Y, Zhao P, Liu X, Dong H, et al. Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling. J Ethnopharmacol. 2020;257:112796 pubmed publisher |
| Wen X, Li H, Sun H, Zeng A, Lin R, Zhao J, et al. MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway. Life Sci. 2020;253:117718 pubmed publisher |
| Jing X, Du L, Niu A, Wang Y, Wang Y, Wang C. Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells. Biomed Res Int. 2020;2020:1276328 pubmed publisher |
| Fang X, Zhou X, Miao Y, Han Y, Wei J, Chen T. Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease. AMB Express. 2020;10:80 pubmed publisher |
| Zhao R, Tian L, Zhao B, Sun Y, Cao J, Chen K, et al. FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling. Cell Death Dis. 2020;11:272 pubmed publisher |
| Yang Z, Li J, Chen W, Kong F. Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling. Cell Biochem Funct. 2020;: pubmed publisher |
| Guan S, Wu Y, Zhang Q, Zhou J. TGF‑β1 induces CREB1‑mediated miR‑1290 upregulation to antagonize lung fibrosis via Napsin A. Int J Mol Med. 2020;46:141-148 pubmed publisher |
| Zhu Y, Shi F, Wang M, Ding J. Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway. Technol Cancer Res Treat. 2020;19:1533033820915958 pubmed publisher |
| Wu H, Wei M, Jiang X, Tan J, Xu W, Fan X, et al. lncRNA PVT1 Promotes Tumorigenesis of Colorectal Cancer by Stabilizing miR-16-5p and Interacting with the VEGFA/VEGFR1/AKT Axis. Mol Ther Nucleic Acids. 2020;20:438-450 pubmed publisher |
| Jing X, Chen Y, Chen Y, Shi G, Lv S, Cheng N, et al. Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion. Cancer Manag Res. 2020;12:2185-2194 pubmed publisher |
| Liang S, Guan H, Lin X, Li N, Geng F, Li J. METTL3 serves an oncogenic role in human ovarian cancer cells partially via the AKT signaling pathway. Oncol Lett. 2020;19:3197-3204 pubmed publisher |
| Meng Q, Xue H. Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway. Technol Cancer Res Treat. 2020;19:1533033820905823 pubmed publisher |
| Su Y, Luo H, Huang C, Liu T, Huang E, Sung M, et al. Galectin-1 Overexpression Activates the FAK/PI3K/AKT/mTOR Pathway and Is Correlated with Upper Urinary Urothelial Carcinoma Progression and Survival. Cells. 2020;9: pubmed publisher |
| Gou W, Li Z, Xu X, Shen J, Guo M, Zhou X, et al. ZX-29, a novel ALK inhibitor, induces apoptosis via ER stress in ALK rearrangement NSCLC cells and overcomes cell resistance caused by an ALK mutation. Biochim Biophys Acta Mol Cell Res. 2020;1867:118712 pubmed publisher |
| Xu F, Xu Y, Xiong J, Zhang J, Wu J, Luo J, et al. AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer. Cancer Manag Res. 2020;12:1789-1798 pubmed publisher |
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| Zhan D, Zhang X, Li J, Ding X, Cui Y, Jia J. MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling. Cancer Biother Radiopharm. 2020;35:223-232 pubmed publisher |
| Gong F, Wang L, Yu L, Dang Y, Jiang X, Zhao L, et al. DHPAC, a novel microtubule depolymerizing agent, suppresses angiogenesis and vasculogenic mimicry formation of human non-small cell lung cancer. J Cell Biochem. 2020;: pubmed publisher |
| Liu Y, Zhang M, He T, Yang W, Wang L, Zhang L, et al. Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling. Clin Epigenetics. 2020;12:22 pubmed publisher |
| Tan X, Zhang K, Xu J, Qu D, Chen L, Li J, et al. Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats. Food Chem Toxicol. 2020;137:111179 pubmed publisher |
| Liu H, Liao W, Fan L, Zheng Z, Liu D, Zhang Q, et al. Ethanol extract of Ophiorrhiza pumila suppresses liver cancer cell proliferation and migration. Chin Med. 2020;15:11 pubmed publisher |
| Wang X, Liu M, Zhu M, Shi L, Liu L, Zhao Y, et al. Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p-Akt pathway in methamphetamine-induced chronic lung injury. Cell Prolif. 2020;53:e12773 pubmed publisher |
| Yang Z, Yang L, Xu C, Wang X, Lei L. An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway. Biol Open. 2020;9: pubmed publisher |
| Huang G, Song C, Wang N, Qin T, Sui S, Obr A, et al. RNA-binding protein CUGBP1 controls the differential INSR splicing in molecular subtypes of breast cancer cells and affects cell aggressiveness. Carcinogenesis. 2020;: pubmed publisher |
| Chen R, Li D, Zheng M, Chen B, Wei T, Wang Y, et al. FGFRL1 affects chemoresistance of small-cell lung cancer by modulating the PI3K/Akt pathway via ENO1. J Cell Mol Med. 2020;24:2123-2134 pubmed publisher |
| Sun X, Yang S, Song W. Prazosin inhibits the proliferation and survival of acute myeloid leukaemia cells through down-regulating TNS1. Biomed Pharmacother. 2020;124:109731 pubmed publisher |
| Zheng Y, Nie P, Xu S. Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis. J Cell Biochem. 2020;: pubmed publisher |
| Gucer H, Caliskan S, Kefeli M, Mete O. Do You Know the Details of Your PAX8 Antibody? Monoclonal PAX8 (MRQ-50) Is Not Expressed in a Series of 45 Medullary Thyroid Carcinomas. Endocr Pathol. 2020;: pubmed publisher |
| Wu P, Shi X, Luo M, Inam U Llah -, Li K, Zhang M, et al. Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway. Amino Acids. 2020;52:87-102 pubmed publisher |
| Yan Z, Zang B, Gong X, Ren J, Wang R. MiR-214-3p exacerbates kidney damages and inflammation induced by hyperlipidemic pancreatitis complicated with acute renal injury. Life Sci. 2020;241:117118 pubmed publisher |
| Liu Q, Zhang S, Zhu D, Tang X, Che Y, Feng X. The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson's disease in mice. Behav Brain Res. 2020;379:112337 pubmed publisher |
| Wang J, Wan D, Wan G, Wang J, Zhang J, Zhu H. Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model. Ann Transl Med. 2019;7:756 pubmed publisher |
| Wu M, Ding Y, Jiang X, Chen Y, Wu N, Li L, et al. Overexpressed MAGP1 Is Associated With a Poor Prognosis and Promotes Cell Migration and Invasion in Gastric Cancer. Front Oncol. 2019;9:1544 pubmed publisher |
| Gong Y, Yang J, Liu Q, Cai J, Zheng Y, Zhang Y, et al. IGF1 Knockdown Hinders Myocardial Development through Energy Metabolism Dysfunction Caused by ROS-Dependent FOXO Activation in the Chicken Heart. Oxid Med Cell Longev. 2019;2019:7838754 pubmed publisher |
| Zeng J, Li X, Cheng Y, Ke B, Wang R. Activation of cannabinoid receptor type 2 reduces lung ischemia reperfusion injury through PI3K/Akt pathway. Int J Clin Exp Pathol. 2019;12:4096-4105 pubmed |
| Zhang C, Wang B, Wang X, Sheng X, Cui Y. Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1). Cancer Cell Int. 2019;19:339 pubmed publisher |
| Huang F, Chen J, Wang J, Zhu P, Lin W. Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway. Biomed Res Int. 2019;2019:8171989 pubmed publisher |
| Wang C, Le Y, Lu D, Zhao M, Dou X, Zhang Q. Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice. J Hazard Mater. 2019;:121732 pubmed publisher |
| Xiao Y, Wei R, Yuan Z, Lan X, Kuang J, Hu D, et al. Rutin suppresses FNDC1 expression in bone marrow mesenchymal stem cells to inhibit postmenopausal osteoporosis. Am J Transl Res. 2019;11:6680-6690 pubmed |
| Luo J, Long Y, Ren G, Zhang Y, Chen J, Huang R, et al. Punicalagin Reversed the Hepatic Injury of Tetrachloromethane by Antioxidation and Enhancement of Autophagy. J Med Food. 2019;22:1271-1279 pubmed publisher |
| Liu J, Hu Y, Feng Y, Guo Y, Liu Y, Yang J, et al. Rafoxanide promotes apoptosis and autophagy of gastric cancer cells by suppressing PI3K /Akt/mTOR pathway. Exp Cell Res. 2019;385:111691 pubmed publisher |
| Li Y, Cao Y, Wang J, Fu S, Cheng J, Ma L, et al. Kp-10 promotes bovine mammary epithelial cell proliferation by activating GPR54 and its downstream signaling pathways. J Cell Physiol. 2019;: pubmed publisher |
| Fujimoto B, Young M, Carter L, Pang A, Corley M, Fogelgren B, et al. The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells. Am J Physiol Endocrinol Metab. 2019;317:E957-E972 pubmed publisher |
| Gao L, Dou Z, Ren W, Li S, Liang X, Zhi K. CircCDR1as upregulates autophagy under hypoxia to promote tumor cell survival via AKT/ERK½/mTOR signaling pathways in oral squamous cell carcinomas. Cell Death Dis. 2019;10:745 pubmed publisher |
| Chen X, Wang M, Yang X, Wang Y, Yu L, Sun J, et al. Injectable hydrogels for the sustained delivery of a HER2-targeted antibody for preventing local relapse of HER2+ breast cancer after breast-conserving surgery. Theranostics. 2019;9:6080-6098 pubmed publisher |
| Jing L, Jiang J, Liu D, Sheng J, Zhang W, Li Z, et al. Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway. Molecules. 2019;24: pubmed publisher |
| Lin J, Jiao A, Lv W, Zhang C, Shi Y, Yang Z, et al. Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway. Front Pharmacol. 2019;10:896 pubmed publisher |
| Qiao X, Zhou Z, Niu R, Su Y, Sun Y, Liu H, et al. Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism. Front Pharmacol. 2019;10:855 pubmed publisher |
| Li K, Shi X, Luo M, Inam U Llah -, Wu P, Zhang M, et al. Taurine protects against myelin damage of sciatic nerve in diabetic peripheral neuropathy rats by controlling apoptosis of schwann cells via NGF/Akt/GSK3β pathway. Exp Cell Res. 2019;:111557 pubmed publisher |
| Guan P, Sun Z, Wang N, Zhou J, Luo L, Zhao Y, et al. Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway. Life Sci. 2019;233:116748 pubmed publisher |
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