This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
PD-L1/CD274
catalog :
66248-1-Ig
quantity :
150UL
price :
299 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2B11D11
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry
citations: 40
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; loading ...; fig 3
Jiao Q, Liu C, Li W, Fang F, Qian Q, Zhang X. Programmed death-1 ligands 1 and 2 expression in cutaneous squamous cell carcinoma and their relationship with tumour- infiltrating dendritic cells. Clin Exp Immunol. 2017;188:420-429 pubmed publisher
Chou C, Yang R, Chan L, Li C, Sun L, Lee H, et al. The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer. Am J Cancer Res. 2020;10:2621-2634 pubmed
Wei J, Wang Y, Lee C, Truillet C, Oh D, Xu Y, et al. An Analysis of Isoclonal Antibody Formats Suggests a Role for Measuring PD-L1 with Low Molecular Weight PET Radiotracers. Mol Imaging Biol. 2020;: pubmed publisher
Lv J, Guo T, Qu X, Che X, Li C, Wang S, et al. PD-L1 Under Regulation of miR-429 Influences the Sensitivity of Gastric Cancer Cells to TRAIL by Binding of EGFR. Front Oncol. 2020;10:1067 pubmed publisher
Pei X, Yao H, Shen L, Yang Y, Lu L, Xiao J, et al. α-Cyperone inhibits the proliferation of human cervical cancer HeLa cells via ROS-mediated PI3K/Akt/mTOR signaling pathway. Eur J Pharmacol. 2020;883:173355 pubmed publisher
Li Q, Chen Q, Klauser P, Li M, Zheng F, Wang N, et al. Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics. Cell. 2020;182:85-97.e16 pubmed publisher
Komura N, Mabuchi S, Shimura K, Yokoi E, Kozasa K, Kuroda H, et al. The role of myeloid-derived suppressor cells in increasing cancer stem-like cells and promoting PD-L1 expression in epithelial ovarian cancer. Cancer Immunol Immunother. 2020;: pubmed publisher
Yan Y, Zheng L, Du Q, Yan B, Geller D. Interferon regulatory factor 1 (IRF-1) and IRF-2 regulate PD-L1 expression in hepatocellular carcinoma (HCC) cells. Cancer Immunol Immunother. 2020;: pubmed publisher
Liu S, Qin T, Liu Z, Wang J, Jia Y, Feng Y, et al. anlotinib alters tumor immune microenvironment by downregulating PD-L1 expression on vascular endothelial cells. Cell Death Dis. 2020;11:309 pubmed publisher
Yang K, Zhou J, Chen Y, Chen L, Zhang P, Ma L, et al. Angiotensin II contributes to intratumoral immunosuppressionvia induction of PD-L1 expression in non-small cell lung carcinoma. Int Immunopharmacol. 2020;84:106507 pubmed publisher
Duan M, Fang M, Wang C, Wang H, Li M. LncRNA EMX2OS Induces Proliferation, Invasion and Sphere Formation of Ovarian Cancer Cells via Regulating the miR-654-3p/AKT3/PD-L1 Axis. Cancer Manag Res. 2020;12:2141-2154 pubmed publisher
Tay W, Fang Y, Beh S, Liu Y, Hsu L, Yen C, et al. Programmed Cell Death-1: Programmed Cell Death-Ligand 1 Interaction Protects Human Cardiomyocytes Against T-Cell Mediated Inflammation and Apoptosis Response In Vitro. Int J Mol Sci. 2020;21: pubmed publisher
Zheng S, Liu Q, Liu T, Yang L, Zhang Q, Shen T, et al. NME4 modulates PD-L1 expression via the STAT3 signaling pathway in squamous cell carcinoma. Biochem Biophys Res Commun. 2020;526:29-34 pubmed publisher
Liu H, Kuang X, Zhang Y, Ye Y, Li J, Liang L, et al. ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis. Cancer Cell. 2020;37:324-339.e8 pubmed publisher
Qin T, Xia J, Liu S, Wang J, Liu H, Zhang Y, et al. Clinical importance of VEGFC and PD-L1 co-expression in lung adenocarcinoma patients. Thorac Cancer. 2020;11:1139-1148 pubmed publisher
Li X, Xu Z, Cui G, Yu L, Zhang X. BTLA Expression in Stage I-III Non-Small-Cell Lung Cancer and Its Correlation with PD-1/PD-L1 and Clinical Outcomes. Onco Targets Ther. 2020;13:215-224 pubmed publisher
Hu M, Yang J, Qu L, Deng X, Duan Z, Fu R, et al. Ginsenoside Rk1 induces apoptosis and downregulates the expression of PD-L1 by targeting the NF-κB pathway in lung adenocarcinoma. Food Funct. 2020;11:456-471 pubmed publisher
Zhang S, Zhou L, Zhang M, Wang Y, Wang M, Du J, et al. Berberine Maintains the Neutrophil N1 Phenotype to Reverse Cancer Cell Resistance to Doxorubicin. Front Pharmacol. 2019;10:1658 pubmed publisher
Wen B, Zhao L, Wang Y, Qiu C, Xu Z, Huang K, et al. Nanobodies targeting the interaction interface of programmed death receptor 1 (PD-1)/PD-1 ligand 1 (PD-1/PD-L1). Prep Biochem Biotechnol. 2019;:1-8 pubmed publisher
Chen M, Gilbert N, Liu H. Reduced expression of PD-L1 in autoimmune thyroiditis attenuate trophoblast invasion through ERK/MMP pathway. Reprod Biol Endocrinol. 2019;17:86 pubmed publisher
Wang Y, Li J, Ba H, Wang K, Wen X, Li D, et al. Down Regulation of c-FLIPL Enhance PD-1 Blockade Efficacy in B16 Melanoma. Front Oncol. 2019;9:857 pubmed publisher
Zhao Y, Wang X, Wu W, Long H, Huang J, Wang Z, et al. EZH2 regulates PD-L1 expression via HIF-1α in non-small cell lung cancer cells. Biochem Biophys Res Commun. 2019;517:201-209 pubmed publisher
Guo C, Zhao H, Wang Y, Bai S, Yang Z, Wei F, et al. Prognostic Value of the Neo-Immunoscore in Renal Cell Carcinoma. Front Oncol. 2019;9:439 pubmed publisher
Li P, Huang T, Zou Q, Liu D, Wang Y, Tan X, et al. FGFR2 Promotes Expression of PD-L1 in Colorectal Cancer via the JAK/STAT3 Signaling Pathway. J Immunol. 2019;202:3065-3075 pubmed publisher
Liu S, Qin T, Jia Y, Li K. PD-L1 Expression Is Associated With VEGFA and LADC Patients' Survival. Front Oncol. 2019;9:189 pubmed publisher
Wang T, Chen S, Wang X, Huang Y, Qiu J, Fei Y, et al. Aberrant PD-1 ligand expression contributes to the myocardial inflammatory injury caused by Coxsackievirus B infection. Antiviral Res. 2019;166:1-10 pubmed publisher
Xu Y, Cui G, Jiang Z, Li N, Zhang X. Survival analysis with regard to PD-L1 and CD155 expression in human small cell lung cancer and a comparison with associated receptors. Oncol Lett. 2019;17:2960-2968 pubmed publisher
Xiong W, Deng H, Huang C, Zen C, Jian C, Ye K, et al. MLL3 enhances the transcription of PD-L1 and regulates anti-tumor immunity. Biochim Biophys Acta Mol Basis Dis. 2019;1865:454-463 pubmed publisher
Liu C, Zhang H, Zhi L, Jin P, Zhao L, Li T, et al. CDK5 Regulates PD-L1 Expression and Cell Maturation in Dendritic Cells of CRSwNP. Inflammation. 2019;42:135-144 pubmed publisher
Amoils M, Kim J, Lee C, Sunwoo J, Colevas A, Aasi S, et al. PD-L1 Expression and Tumor-Infiltrating Lymphocytes in High-Risk and Metastatic Cutaneous Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. 2019;160:93-99 pubmed publisher
Jin J, Si J, Liu Y, Wang H, Ni R, Wang J. Elevated serum soluble programmed cell death ligand 1 concentration as a potential marker for poor prognosis in small cell lung cancer patients with chemotherapy. Respir Res. 2018;19:197 pubmed publisher
Guo J, Qu H, Shan T, Chen Y, Chen Y, Xia J. Tristetraprolin Overexpression in Gastric Cancer Cells Suppresses PD-L1 Expression and Inhibits Tumor Progression by Enhancing Antitumor Immunity. Mol Cells. 2018;41:653-664 pubmed publisher
Zhen J, Chen W. MiR-142 inhibits cecal ligation and puncture (CLP)-induced inflammation via inhibiting PD-L1 expression in macrophages and improves survival in septic mice. Biomed Pharmacother. 2018;97:1479-1485 pubmed publisher
Hsu J, Xia W, Hsu Y, Chan L, Yu W, Cha J, et al. STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion. Nat Commun. 2018;9:1908 pubmed publisher
Cannon J, Russell J, Kim J, Chang A. A case of metastatic basal cell carcinoma treated with continuous PD-1 inhibitor exposure even after subsequent initiation of radiotherapy and surgery. JAAD Case Rep. 2018;4:248-250 pubmed publisher
Dai X, Pi G, Yang S, Chen G, Liu L, Dong H. Association of PD-L1 and HIF-1α Coexpression with Poor Prognosis in Hepatocellular Carcinoma. Transl Oncol. 2018;11:559-566 pubmed publisher
Dai X, Xue J, Hu J, Yang S, Chen G, Lai P, et al. Positive Expression of Programmed Death Ligand 1 in Peritumoral Liver Tissue is Associated with Poor Survival after Curative Resection of Hepatocellular Carcinoma. Transl Oncol. 2017;10:511-517 pubmed publisher
Chang J, Zhu G, Cheung C, Li S, Kim J, Chang A. Association Between Programmed Death Ligand 1 Expression in Patients With Basal Cell Carcinomas and the Number of Treatment Modalities. JAMA Dermatol. 2017;153:285-290 pubmed publisher
Pi G, He H, Bi J, Li Y, Li Y, Zhang Y, et al. Efficacy of short-term nivolumab treatment in a Chinese patient with relapsed advanced-stage lung squamous cell carcinoma: A case report. Medicine (Baltimore). 2016;95:e5077 pubmed
Song Z, Yu X, Cheng G, Zhang Y. Programmed death-ligand 1 expression associated with molecular characteristics in surgically resected lung adenocarcinoma. J Transl Med. 2016;14:188 pubmed publisher
product information
CatalogNo :
66248-1-Ig
AntigenName :
PD-L1/CD274
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
CD274 molecule
Immunogen :
Recombinant Protein
Species :
human, mouse, pig, rat
Host :
Mouse
IsConjugated :
Unconjugated
AntigenSpecies :
human
CloneNo :
2B11D11
Application :
WB, IHC, IF, FC, ELISA
Clonlity :
Monoclonal
IsoType :
IgG1
Synonyms :
B7 H, B7 H1, B7 homolog 1, B7H1, CD274, CD274 molecule, PD L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, PD-L1, PD-L1/CD274, Programmed death ligand 1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC074984
PurifyMethod :
Protein G purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
FC 1:0 ; IF 1:300 ; IHC 1:10000 ; WB 1:5000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.