This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
BAX
catalog :
60267-1-Ig
quantity :
150UL
price :
299 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4G5E8
reactivity :
human, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
citations: 52
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1500; loading ...; fig 4c, 5d
Ding X, Hu H, Huang K, Wei R, Min J, Qi C, et al. Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma. Cancer Sci. 2020;111:489-501 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 1b
Wu Y, Zhao Y, He X, He Z, Wang T, Wan L, et al. Hydroxypropyl‑β‑cyclodextrin attenuates the epithelial‑to‑mesenchymal transition via endoplasmic reticulum stress in MDA‑MB‑231 breast cancer cells. Mol Med Rep. 2019;: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1f
Feng J, Wu L, Ji J, Chen K, Yu Q, Zhang J, et al. PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma. J Exp Clin Cancer Res. 2019;38:204 pubmed publisher
  • western blot; rat; 1:500; loading ...; fig 3d
Zhang C, Li L, Zhao B, Jiao A, Li X, Sun N, et al. Ghrelin Protects against Dexamethasone-Induced INS-1 Cell Apoptosis via ERK and p38MAPK Signaling. Int J Endocrinol. 2016;2016:4513051 pubmed publisher
  • western blot; rat; 1:2000; loading ...; fig 7a
Kong F, Wang H, Guo J, Peng M, Ji H, Yang H, et al. Hsp70 suppresses apoptosis of BRL cells by regulating the expression of Bcl-2, cytochrome C, and caspase 8/3. In Vitro Cell Dev Biol Anim. 2016;52:568-75 pubmed publisher
Sha L, Ma D, Chen C. Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway. Aging (Albany NY). 2020;12:23598-23608 pubmed publisher
Xiong S, Han Y, Gao P, Zhao H, Jiang N, Sun L. AdipoRon Protects against Tubular Injury in Diabetic Nephropathy by Inhibiting Endoplasmic Reticulum Stress. Oxid Med Cell Longev. 2020;2020:6104375 pubmed publisher
Wang C, Yang J, Guo Y, Shen J, Pei X. Anticancer Activity of Tetrandrine by Inducing Apoptosis in Human Breast Cancer Cell Line MDA-MB-231 In Vivo. Evid Based Complement Alternat Med. 2020;2020:6823520 pubmed publisher
Li M, Alsager J, Wang Z, Cheng L, Shan B. Epigenetic upregulation of HOXC10 in non-small lung cancer cells. Aging (Albany NY). 2020;12:16921-16935 pubmed publisher
Niu Q, Sun W, Chen Q, Long Y, Cao W, Wen S, et al. Protective Effects of Ischemic Postconditioning on Livers in Rats with Limb Ischemia-Reperfusion via Glycogen Synthase Kinase 3 beta (GSK-3β)/Fyn/Nuclear Receptor-Erythroid-2-Related Factor (Nrf2) Pathway. Med Sci Monit. 2020;26:e923049 pubmed publisher
Feng Q, Bian X, Liu X, Wang Y, Zhou H, Ma X, et al. Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy. BMC Cancer. 2020;20:665 pubmed publisher
Zou Y, Li R, Kuang D, Zuo M, Li W, Tong W, et al. Galangin Inhibits Cholangiocarcinoma Cell Growth and Metastasis through Downregulation of MicroRNA-21 Expression. Biomed Res Int. 2020;2020:5846938 pubmed publisher
Hu X, Li R, Wu Y, Li Y, Zhong X, Zhang G, et al. Thermosensitive heparin-poloxamer hydrogel encapsulated bFGF and NGF to treat spinal cord injury. J Cell Mol Med. 2020;: pubmed publisher
Li L, Peng X, Guo L, Zhao Y, Cheng Q. Sepsis causes heart injury through endoplasmic reticulum stress-mediated apoptosis signaling pathway. Int J Clin Exp Pathol. 2020;13:964-971 pubmed
Ji J, Wu L, Feng J, Mo W, Wu J, Yu Q, et al. Cafestol preconditioning attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting ERK/PPARγ pathway. Int Immunopharmacol. 2020;84:106529 pubmed publisher
Feng A, Han X, Meng X, Chen Z, Li Q, Shu W, et al. PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/β-catenin and AKT pathways. Clin Transl Oncol. 2020;22:1838-1848 pubmed publisher
Li B, Zhu F, He F, Huang Q, Liu X, Wu T, et al. Synthesis and biological evaluations of N'-substituted methylene-4-(quinoline-4-amino) benzoylhydrazides as potential anti-hepatoma agents. Bioorg Chem. 2020;96:103592 pubmed publisher
Feng J, Dai W, Mao Y, Wu L, Li J, Chen K, et al. Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis. J Exp Clin Cancer Res. 2020;39:24 pubmed publisher
Yang K, Lu T, Zhan L, Zhou C, Zhang N, Lei S, et al. Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell. Int J Biol Macromol. 2020;149:320-330 pubmed publisher
Zheng Y, Nie P, Xu S. Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis. J Cell Biochem. 2020;: pubmed publisher
Zhang J, Chen Y, Lin J, Jia R, An T, Dong T, et al. Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma. DNA Cell Biol. 2020;: pubmed publisher
Lin Y, Yu M, Fan T. Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells. Toxicol Lett. 2020;320:9-18 pubmed publisher
Yang J, Zhu X, Jin M, Cao Z, Ren Y, Gu Z. Osthole induces cell cycle arrest and apoptosis in head and neck squamous cell carcinoma by suppressing the PI3K/AKT signaling pathway. Chem Biol Interact. 2019;316:108934 pubmed publisher
Zhang L, Wang F, Zhang Q, Liang Q, Wang S, Xian M, et al. Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells. Int J Mol Sci. 2019;20: pubmed publisher
Li F, Wu J, Wang P, Qu L. NKAP functions as an oncogene in Ewing sarcoma cells partly through the AKT signaling pathway. Exp Ther Med. 2019;18:3037-3045 pubmed publisher
Zilberman Itskovich S, Abu Hamad R, Zarura R, Sova M, Hachmo Y, Stark M, et al. Human mesenchymal stromal cells ameliorate complement induced inflammatory cascade and improve renal functions in a rat model of ischemia-reperfusion induced acute kidney injury. PLoS ONE. 2019;14:e0222354 pubmed publisher
Song T, Ma K, Zhao C, Yang J, Liu J. MicroRNA-2053 overexpression inhibits the development and progression of hepatocellular carcinoma. Oncol Lett. 2019;18:2043-2049 pubmed publisher
Ma Y, Guan L, Han Y, Zhou Y, Li X, Liu Y, et al. siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway. Cancer Manag Res. 2019;11:5799-5811 pubmed publisher
Li T, Chen L, Wang S, Yang Y, Xu H, Gu H, et al. Magnesium isoglycyrrhizinate ameliorates fructose-induced podocyte apoptosis through downregulation of miR-193a to increase WT1. Biochem Pharmacol. 2019;166:139-152 pubmed publisher
Tian X, An R, Luo Y, Li M, Xu L, Dong Z. Tamibarotene Improves Hippocampus Injury Induced by Focal Cerebral Ischemia-Reperfusion via Modulating PI3K/Akt Pathway in Rats. J Stroke Cerebrovasc Dis. 2019;28:1832-1840 pubmed publisher
Liu P, Yao R, Shi H, Liu Y, Lian S, Yang Y, et al. Effects of Cold-inducible RNA-binding Protein (CIRP) on Liver Glycolysis during Acute Cold Exposure in C57BL/6 Mice. Int J Mol Sci. 2019;20: pubmed publisher
Shi H, Yao R, Lian S, Liu P, Liu Y, Yang Y, et al. Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure. Stress. 2019;22:366-376 pubmed publisher
Chen B, Yang L, Chen J, Chen Y, Zhang L, Wang L, et al. Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia/reperfusion injury via the JAK2/STAT3 pathway in mice. Brain Res Bull. 2019;146:124-135 pubmed publisher
Deng J, Feng J, Liu T, Lu X, Wang W, Liu N, et al. Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways. Drug Des Devel Ther. 2018;12:4067-4082 pubmed publisher
Liu Z, Xie J, Lin K, Qi L. Influencing mechanism of magnolol on expression of BDNF and Bax in rats with cerebral ischemic stroke. Exp Ther Med. 2018;16:4423-4428 pubmed publisher
Ou B, Tao W, Yang S, Feng J, Wang J, Yang T, et al. The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3K/Akt Pathway. Evid Based Complement Alternat Med. 2018;2018:7290170 pubmed publisher
Sun N, Zhang J, Zhang C, Zhao B, Jiao A. DNMTs inhibitor SGI-1027 induces apoptosis in Huh7 human hepatocellular carcinoma cells. Oncol Lett. 2018;16:5799-5806 pubmed publisher
Yue X, Li M, Chen D, Xu Z, Sun S. UNBS5162 induces growth inhibition and apoptosis via inhibiting PI3K/AKT/mTOR pathway in triple negative breast cancer MDA-MB-231 cells. Exp Ther Med. 2018;16:3921-3928 pubmed publisher
Zhang P, Hua L, Hou H, Du X, He Z, Liu M, et al. Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway. Int J Mol Med. 2018;42:3344-3354 pubmed publisher
Yao R, Yang Y, Lian S, Shi H, Liu P, Liu Y, et al. Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice. Int J Mol Sci. 2018;19: pubmed publisher
Yin Y, Xu M, Gao J, Li M. Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling. Pathol Res Pract. 2018;214:1381-1387 pubmed publisher
Xue S, He W, Zeng X, Tang Z, Feng S, Zhong Z, et al. Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway. Mol Med Rep. 2018;18:815-826 pubmed publisher
Feng J, Niu P, Chen K, Wu L, Liu T, Xu S, et al. Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury. Exp Ther Med. 2018;15:4599-4614 pubmed publisher
Li M, Tian X, An R, Yang M, Zhang Q, Xiang F, et al. All-Trans Retinoic Acid Ameliorates the Early Experimental Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting the Loss of the Blood-Brain Barrier via the JNK/P38MAPK Signaling Pathway. Neurochem Res. 2018;43:1283-1296 pubmed publisher
Lu K, Rui G, Liu F, Yang L, Deng X, Shi S, et al. 14-3-3? is a nuclear matrix protein, and its altered expression and localization are associated with curcumin-induced apoptosis of MG-63 cells. Oncol Lett. 2018;15:338-346 pubmed publisher
Xu X, Li D, Li X, Shi Q, Ju X. Mesenchymal stem cell conditioned medium alleviates oxidative stress injury induced by hydrogen peroxide via regulating miR143 and its target protein in hepatocytes. BMC Immunol. 2017;18:51 pubmed publisher
Tang Z, Zhang Z, Tang Y, Qi L, Yang F, Wang Z. Effects of dimethyl carbonate-induced autophagic activation on follicular development in the mouse ovary. Exp Ther Med. 2017;14:5981-5989 pubmed publisher
Li B, Hou D, Guo H, Zhou H, Zhang S, Xu X, et al. Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells. Sci Rep. 2017;7:208 pubmed publisher
Zhang J, Wang R, Xi J, Shen L, Zhu A, Qi Q, et al. Morroniside protects SK-N-SH human neuroblastoma cells against H2O2-induced damage. Int J Mol Med. 2017;39:603-612 pubmed publisher
Zhao X, Wu Q, Peng J, Pan L, Ren Z, Liu H, et al. Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression. Mol Med Rep. 2017;15:712-718 pubmed publisher
Yang J, Qiao L, Zeng Z, Wang J, Zhu T, Wei J, et al. The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD. Toxicol Lett. 2017;265:131-139 pubmed publisher
Luo J, Wu N, Jiang B, Wang L, Wang S, Li X, et al. Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition. Mar Drugs. 2015;13:4452-69 pubmed publisher
product information
CatalogNo :
60267-1-Ig
AntigenName :
BAX
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
BCL2-associated X protein
Immunogen :
Fusion Protein
Species :
human, mouse, rat
Host :
Mouse
IsConjugated :
Unconjugated
AntigenSpecies :
human
CloneNo :
4G5E8
Application :
WB, IHC, IF, ELISA
Clonlity :
Monoclonal
IsoType :
IgG2b
Synonyms :
Apoptosis regulator BAX, BAX
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC014175
Category :
Apoptosis;Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;Development;Membrane Proteins;Neurology;Oncogene(s) and Tumor Suppressor(s);
PurifyMethod :
Protein A purification
NewAb :
False
IsSellable :
True
AppTiter :
IHC 1:1000 ; WB 1:20000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.