This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
PI3K p85 alpha
catalog :
60225-1-Ig
quantity :
150UL
price :
299 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4G3C11
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 30
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:1000; loading ...; fig 8c
Nan L, Wang F, Ran D, Zhou S, Liu Y, Zhang Z, et al. Naringin alleviates H2O2-induced apoptosis via the PI3K/Akt pathway in rat nucleus pulposus-derived mesenchymal stem cells. Connect Tissue Res. 2019;:1-14 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 4a
  • western blot; mouse; 1:100; fig 4c
Wang X, Han Y, Liu J, Zhang Y, Cheng K, Guo J, et al. Exosomes Play an Important Role in the Progression of Plasma Cell Mastitis via the PI3K-Akt-mTOR Signaling Pathway. Mediators Inflamm. 2019;2019:4312016 pubmed publisher
  • western blot; human; loading ...; fig 7a, 7b
Ortega F, Roefs M, De Miguel Pérez D, Kooijmans S, de Jong O, Sluijter J, et al. Interfering with endolysosomal trafficking enhances release of bioactive exosomes. Nanomedicine. 2019;:102014 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 5c
Guo Y, Pei X. Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling. Evid Based Complement Alternat Med. 2019;2019:7517431 pubmed publisher
  • western blot; human; loading ...; fig 5a
Dong X, Yang Y, Zhou Y, Bi X, Zhao N, Zhang Z, et al. Glutathione S-transferases P1 protects breast cancer cell from adriamycin-induced cell death through promoting autophagy. Cell Death Differ. 2019;: pubmed publisher
Kang D, Zuo W, Wu Q, Zhu Q, Liu P. Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer. Biomed Res Int. 2020;2020:1358674 pubmed publisher
Wei Z, Hao Y, Yu H, Shi L, Jing X, Zhang X, et al. Disordered Leptin signaling in the retrotrapezoid nucleus is associated with the impaired hypercapnic ventilatory response in obesity. Life Sci. 2020;257:117994 pubmed publisher
Fan Z, Liu Y, Shi Z, Deng K, Zhang H, Li Q, et al. MiR-155 promotes interleukin-1β-induced chondrocyte apoptosis and catabolic activity by targeting PIK3R1-mediated PI3K/Akt pathway. J Cell Mol Med. 2020;24:8441-8451 pubmed publisher
Yang Y, Wang F, Lin H, Huang Y. Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha. Int J Mol Sci. 2020;21: pubmed publisher
Wang Y, Zhang J, Su Y, Wang C, Zhang G, Liu X, et al. miRNA-98-5p Targeting IGF2BP1 Induces Mesenchymal Stem Cell Apoptosis by Modulating PI3K/Akt and p53 in Immune Thrombocytopenia. Mol Ther Nucleic Acids. 2020;20:764-776 pubmed publisher
Chen Y, Tang J, Lu T, Liu F. CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma. Thorac Cancer. 2020;11:1848-1860 pubmed publisher
Zhai R, Xu H, Hu F, Wu J, Kong X, Sun X. Exendin-4, a GLP-1 receptor agonist regulates retinal capillary tone and restores microvascular patency after ischaemia-reperfusion injury. Br J Pharmacol. 2020;: pubmed publisher
Lian J, Zou Y, Huang L, Cheng H, Huang K, Zeng J, et al. Hepatitis B virus upregulates cellular inhibitor of apoptosis protein 2 expression via the PI3K/AKT/NF-κB signaling pathway in liver cancer. Oncol Lett. 2020;19:2043-2052 pubmed publisher
Pi S, Mao L, Chen J, Shi H, Liu Y, Guo X, et al. The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis. Autophagy. 2020;:1-21 pubmed publisher
Zheng J, Qu D, Wang C, Ding L, Zhou W. Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling. BMC Pregnancy Childbirth. 2020;20:87 pubmed publisher
Alarabi A, Karim Z, Ramirez J, Hernandez K, Lozano P, Rivera J, et al. Short-Term Exposure to Waterpipe/Hookah Smoke Triggers a Hyperactive Platelet Activation State and Increases the Risk of Thrombogenesis. Arterioscler Thromb Vasc Biol. 2020;40:335-349 pubmed publisher
Wang J, Wan D, Wan G, Wang J, Zhang J, Zhu H. Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model. Ann Transl Med. 2019;7:756 pubmed publisher
Zhang Y, Yang S, Cui X, Yang J, Zheng M, Jia J, et al. Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway. J Diabetes Res. 2019;2019:4709715 pubmed publisher
Ye Z, Zhang S, Liu Y, Wang S, Zhang J, Huang R. A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation. Mediators Inflamm. 2019;2019:8709583 pubmed publisher
Wu X, Li S, Wang K, Hua W, Li S, Song Y, et al. TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling. Inflammation. 2019;: pubmed publisher
Zeng Z, Lin J, Xu C, Cao L, Chen C, Li J. Minimally modified low-density lipoprotein upregulates the ETB and α1 receptors in mouse mesenteric arteries in vivo by activating the PI3K/Akt pathway. J Pharm Pharmacol. 2019;71:937-944 pubmed publisher
Ou B, Tao W, Yang S, Feng J, Wang J, Yang T, et al. The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3K/Akt Pathway. Evid Based Complement Alternat Med. 2018;2018:7290170 pubmed publisher
Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, et al. Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo. J Cell Physiol. 2018;234:777-788 pubmed publisher
Wu Z, Zhu Q, Yin Y, Kang D, Cao R, Tian Q, et al. Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer. Cancer Med. 2018;7:1546-1559 pubmed publisher
Wang X, Li D, Fan L, Xiao Q, Zuo H, Li Z. CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NF-?B/ iNOS pathway in STZ-induced diabetic mice. Oncotarget. 2017;8:114506-114525 pubmed publisher
Zhou P, Tu L, Lin X, Hao X, Zheng Q, Zeng W, et al. cfa-miR-143 Promotes Apoptosis via the p53 Pathway in Canine Influenza Virus H3N2-Infected Cells. Viruses. 2017;9: pubmed publisher
Chen X, Zhao X, Lan F, Zhou T, Cai H, Sun H, et al. Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells. Sci Rep. 2017;7:13248 pubmed publisher
Chen X, Zhao X, Cai H, Sun H, Hu Y, Huang X, et al. The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways. Redox Biol. 2017;12:987-1003 pubmed publisher
Ma F, Liu F, Ding L, You M, Yue H, Zhou Y, et al. Anti-inflammatory effects of curcumin are associated with down regulating microRNA-155 in LPS-treated macrophages and mice. Pharm Biol. 2017;55:1263-1273 pubmed publisher
Wu Z, Tao Z, Zhang J, Li T, Ni C, Xie J, et al. MiRNA-21 induces epithelial to mesenchymal transition and gemcitabine resistance via the PTEN/AKT pathway in breast cancer. Tumour Biol. 2016;37:7245-54 pubmed publisher
product information
CatalogNo :
60225-1-Ig
AntigenName :
PI3K p85 alpha
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Immunogen :
Fusion Protein
Species :
dog, human, mouse, pig, rat
Host :
Mouse
IsConjugated :
Unconjugated
AntigenSpecies :
human
CloneNo :
4G3C11
Application :
WB, IP, IHC, ELISA
Clonlity :
Monoclonal
IsoType :
IgG2a
Synonyms :
GRB1, p85, p85 ALPHA, PI 3 Kinase p85 alpha, PI 3-kinase p85α, PI3 kinase subunit p85 alpha, PI3K p85(alpha), PI3K regulatory subunit alpha, PIK3R1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC030815
Category :
Binding Proteins;Membrane Proteins;Signal transduction;
PurifyMethod :
Protein A purification
NewAb :
False
IsSellable :
True
AppTiter :
IP 1:500 ; WB 1:15000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.