This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
BCL2
catalog :
60178-1-Ig
quantity :
150UL
price :
299 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4H8C6
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 46
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 3b
Yue G, Chen C, Bai L, Wang G, Huang Y, Wang Y, et al. Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway. Mol Med Rep. 2019;20:4551-4557 pubmed publisher
  • western blot; human; 1:1000; fig 1a, 1d
He Z, Du X, Wu Y, Hua L, Wan L, Yan N. Simvastatin promotes endothelial dysfunction by activating the Wnt/β‑catenin pathway under oxidative stress. Int J Mol Med. 2019;44:1289-1298 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2f
Yang N, Li C, Li H, Liu M, Cai X, Cao F, et al. Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells. Front Pharmacol. 2019;10:709 pubmed publisher
  • western blot; human; 1:1000; fig 5b
Hua L, Wu N, Zhao R, He X, Liu Q, Li X, et al. Sphingomyelin Synthase 2 Promotes Endothelial Dysfunction by Inducing Endoplasmic Reticulum Stress. Int J Mol Sci. 2019;20: pubmed publisher
Wang C, Yang J, Guo Y, Shen J, Pei X. Anticancer Activity of Tetrandrine by Inducing Apoptosis in Human Breast Cancer Cell Line MDA-MB-231 In Vivo. Evid Based Complement Alternat Med. 2020;2020:6823520 pubmed publisher
Wang X, Lin Y, Zheng Y. Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration. Mol Med Rep. 2020;22:2318-2328 pubmed publisher
Niu Q, Sun W, Chen Q, Long Y, Cao W, Wen S, et al. Protective Effects of Ischemic Postconditioning on Livers in Rats with Limb Ischemia-Reperfusion via Glycogen Synthase Kinase 3 beta (GSK-3β)/Fyn/Nuclear Receptor-Erythroid-2-Related Factor (Nrf2) Pathway. Med Sci Monit. 2020;26:e923049 pubmed publisher
Feng Q, Bian X, Liu X, Wang Y, Zhou H, Ma X, et al. Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy. BMC Cancer. 2020;20:665 pubmed publisher
Zou Y, Li R, Kuang D, Zuo M, Li W, Tong W, et al. Galangin Inhibits Cholangiocarcinoma Cell Growth and Metastasis through Downregulation of MicroRNA-21 Expression. Biomed Res Int. 2020;2020:5846938 pubmed publisher
Hu X, Li R, Wu Y, Li Y, Zhong X, Zhang G, et al. Thermosensitive heparin-poloxamer hydrogel encapsulated bFGF and NGF to treat spinal cord injury. J Cell Mol Med. 2020;: pubmed publisher
Wang L, Lv Y, Liu G. The roles of SHANK1 in the development of colon cancer. Cell Biochem Funct. 2020;: pubmed publisher
Liang S, Guan H, Lin X, Li N, Geng F, Li J. METTL3 serves an oncogenic role in human ovarian cancer cells partially via the AKT signaling pathway. Oncol Lett. 2020;19:3197-3204 pubmed publisher
Bi H, Li Z, Zhang H. Long noncoding RNA HAND2-AS1 reduced the viability of hepatocellular carcinoma via targeting microRNA-300/SOCS5 axis. Hepatobiliary Pancreat Dis Int. 2020;: pubmed publisher
Li B, Zhu F, He F, Huang Q, Liu X, Wu T, et al. Synthesis and biological evaluations of N'-substituted methylene-4-(quinoline-4-amino) benzoylhydrazides as potential anti-hepatoma agents. Bioorg Chem. 2020;96:103592 pubmed publisher
Zhang W, Gao J, Cheng C, Zhang M, Liu W, Ma X, et al. Cinnamaldehyde Enhances Antimelanoma Activity through Covalently Binding ENO1 and Exhibits a Promoting Effect with Dacarbazine. Cancers (Basel). 2020;12: pubmed publisher
Yang K, Lu T, Zhan L, Zhou C, Zhang N, Lei S, et al. Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell. Int J Biol Macromol. 2020;149:320-330 pubmed publisher
Liao X, Song G, Xu Z, Bu Y, Chang F, Jia F, et al. Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma. BMC Cancer. 2020;20:31 pubmed publisher
Zheng Y, Nie P, Xu S. Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis. J Cell Biochem. 2020;: pubmed publisher
Zhang J, Chen Y, Lin J, Jia R, An T, Dong T, et al. Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma. DNA Cell Biol. 2020;: pubmed publisher
Lin Y, Yu M, Fan T. Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells. Toxicol Lett. 2020;320:9-18 pubmed publisher
Yao P, Sheng M, Weng W, Long Y, Liu H, Chen L, et al. High glucose causes apoptosis of rabbit corneal epithelial cells involving activation of PERK-eIF2α-CHOP-caspase-12 signaling pathway. Int J Ophthalmol. 2019;12:1815-1822 pubmed publisher
Zhang L, Wang F, Zhang Q, Liang Q, Wang S, Xian M, et al. Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells. Int J Mol Sci. 2019;20: pubmed publisher
Chen S, Wang J, Wang L, Peng H, Xiao L, Li C, et al. Silencing TTK expression inhibits the proliferation and progression of prostate cancer. Exp Cell Res. 2019;385:111669 pubmed publisher
Ye M, Ma J, Liu B, Liu X, Ma D, Dong K. Linc01105 acts as an oncogene in the development of neuroblastoma. Oncol Rep. 2019;: pubmed publisher
Wang C, Cheng G, Yang S, Li L, Zhang Y, Zhao X, et al. Protective effects of Platycodon grandiflorus polysaccharides against apoptosis induced by carbonyl cyanide 3-chlorophenylhydrazone in 3D4/21 cells. Int J Biol Macromol. 2019;141:1220-1227 pubmed publisher
Song T, Ma K, Zhao C, Yang J, Liu J. MicroRNA-2053 overexpression inhibits the development and progression of hepatocellular carcinoma. Oncol Lett. 2019;18:2043-2049 pubmed publisher
Wei Z, Xu H, Zhang Y, Yi X, Yang X, Chen Y, et al. Rho GDP dissociation inhibitor α silencing attenuates silicosis by inhibiting RhoA/Rho kinase signalling. Exp Cell Res. 2019;380:131-140 pubmed publisher
Liu P, Yao R, Shi H, Liu Y, Lian S, Yang Y, et al. Effects of Cold-inducible RNA-binding Protein (CIRP) on Liver Glycolysis during Acute Cold Exposure in C57BL/6 Mice. Int J Mol Sci. 2019;20: pubmed publisher
Shi H, Yao R, Lian S, Liu P, Liu Y, Yang Y, et al. Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure. Stress. 2019;22:366-376 pubmed publisher
Li L, Liu M, Zhang Z, Zhang W, Liu N, Sheng X, et al. Derlin1 functions as an oncogene in cervical cancer via AKT/mTOR signaling pathway. Biol Res. 2019;52:8 pubmed publisher
Li K, Meng Z, Jiang L, Xia C, Xu K, Yuan D, et al. CDKL1 promotes the chemoresistance of human oral squamous cell carcinoma cells to hydroxycamptothecin. Mol Cell Probes. 2019;44:57-62 pubmed publisher
Li Z, Li Q, Lv W, Jiang L, Geng C, Yao X, et al. The interaction of Atg4B and Bcl-2 plays an important role in Cd-induced crosstalk between apoptosis and autophagy through disassociation of Bcl-2-Beclin1 in A549 cells. Free Radic Biol Med. 2019;130:576-591 pubmed publisher
Liu L, Sun Y, Zhao Y, Wang Q, Guo H, Guo R, et al. Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis. Cancer Sci. 2018;109:3762-3773 pubmed publisher
Yao R, Yang Y, Lian S, Shi H, Liu P, Liu Y, et al. Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice. Int J Mol Sci. 2018;19: pubmed publisher
Yin Y, Xu M, Gao J, Li M. Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling. Pathol Res Pract. 2018;214:1381-1387 pubmed publisher
Meng M, Chen Y, Jia J, Li L, Yang S. Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines. Biol Res. 2018;51:24 pubmed publisher
Zhang Z, Wen F, He C, Yu J. Resveratrol attenuates mechanical compression-induced nucleus pulposus cell apoptosis through regulating the ERK1/2 signaling pathway in a disc organ culture. Biosci Rep. 2018;38: pubmed publisher
Lu K, Rui G, Liu F, Yang L, Deng X, Shi S, et al. 14-3-3? is a nuclear matrix protein, and its altered expression and localization are associated with curcumin-induced apoptosis of MG-63 cells. Oncol Lett. 2018;15:338-346 pubmed publisher
Li B, Hou D, Guo H, Zhou H, Zhang S, Xu X, et al. Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells. Sci Rep. 2017;7:208 pubmed publisher
Yang J, Qiao L, Zeng Z, Wang J, Zhu T, Wei J, et al. The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD. Toxicol Lett. 2017;265:131-139 pubmed publisher
Wang D, Wang D, Wang N, Long Z, Ren X. Long Non-Coding RNA BANCR Promotes Endometrial Cancer Cell Proliferation and Invasion by Regulating MMP2 and MMP1 via ERK/MAPK Signaling Pathway. Cell Physiol Biochem. 2016;40:644-656 pubmed
Yang T, Xu F, Sheng Y, Zhang W, Chen Y. A targeted proteomics approach to the quantitative analysis of ERK/Bcl-2-mediated anti-apoptosis and multi-drug resistance in breast cancer. Anal Bioanal Chem. 2016;408:7491-503 pubmed publisher
Duan X, Wang W, Liu X, Yan H, Dai R, Lin Q. Neuroprotective effect of ethyl acetate extract from gastrodia elata against transient focal cerebral ischemia in rats induced by middle cerebral artery occlusion. J Tradit Chin Med. 2015;35:671-8 pubmed
Sun Y, Liu Z, Zou X, Lan Y, Sun X, Wang X, et al. Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer. J Bioenerg Biomembr. 2015;47:319-29 pubmed publisher
Liu C, Hong T, Shao M, Chen Z, Wang C. Melatonin synergized with cyclosporine A improves cardiac allograft survival by suppressing inflammation and apoptosis. Mol Med Rep. 2014;10:1323-8 pubmed publisher
Zeng J, Dai P, Ren L, Song B, Chen X, Wang X, et al. Apoptosis-induced anti-tumor effect of Curcuma kwangsiensis polysaccharides against human nasopharyngeal carcinoma cells. Carbohydr Polym. 2012;89:1067-72 pubmed publisher
product information
CatalogNo :
60178-1-Ig
AntigenName :
BCL2
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
B-cell CLL/lymphoma 2
Immunogen :
Recombinant Protein
Species :
human, mouse, pig, rat, swine
Host :
Mouse
IsConjugated :
Unconjugated
AntigenSpecies :
human
CloneNo :
4H8C6
Application :
WB, IP, IHC, IF, FC, CoIP, ELISA
Clonlity :
Monoclonal
IsoType :
IgG2b
Synonyms :
Apoptosis regulator Bcl 2, B cell CLL/lymphoma 2, BCL2, BCL-2, Oncogene B cell leukemia 2
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC027258
Category :
Apoptosis;Autophagy;Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;IVD;Membrane Proteins;Neurology;Oncogene(s) and Tumor Suppressor(s);
PurifyMethod :
Protein A purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
FC 1:0 ; IF 1:100 ; IHC 1:12800 ; IP 1:1000 ; WB 1:5000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.