This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
FUS/TLS
catalog :
60160-1-Ig
quantity :
150UL
price :
299 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3A10B5
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 11
Reference
Collins M, Li Y, Bowser R. RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases. Acta Neuropathol Commun. 2020;8:91 pubmed publisher
Matsumoto T, Matsukawa K, Watanabe N, Kishino Y, Kunugi H, Ihara R, et al. Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration. Hum Mol Genet. 2018;27:1353-1365 pubmed publisher
Chen Y, Deng J, Wang P, Yang M, Chen X, Zhu L, et al. PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration. Hum Mol Genet. 2016;25:5059-5068 pubmed publisher
Hu B, Arpag S, Zuchner S, Li J. A novel missense mutation of CMT2P alters transcription machinery. Ann Neurol. 2016;80:834-845 pubmed publisher
Denora P, Smets K, Zolfanelli F, Ceuterick de Groote C, Casali C, Deconinck T, et al. Motor neuron degeneration in spastic paraplegia 11 mimics amyotrophic lateral sclerosis lesions. Brain. 2016;139:1723-34 pubmed publisher
Deng J, Yang M, Chen Y, Chen X, Liu J, Sun S, et al. FUS Interacts with HSP60 to Promote Mitochondrial Damage. PLoS Genet. 2015;11:e1005357 pubmed publisher
Lu L, Zheng L, Si Y, Luo W, Dujardin G, Kwan T, et al. Hu antigen R (HuR) is a positive regulator of the RNA-binding proteins TDP-43 and FUS/TLS: implications for amyotrophic lateral sclerosis. J Biol Chem. 2014;289:31792-804 pubmed publisher
McGurk L, Lee V, Trojanowksi J, Van Deerlin V, Lee E, Bonini N. Poly-A binding protein-1 localization to a subset of TDP-43 inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72. J Neuropathol Exp Neurol. 2014;73:837-45 pubmed publisher
Yasuda K, Zhang H, Loiselle D, Haystead T, Macara I, Mili S. The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules. J Cell Biol. 2013;203:737-46 pubmed publisher
Lee E, Russ J, Jung H, Elman L, Chahine L, Kremens D, et al. Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U. Acta Neuropathol Commun. 2013;1:1-11 pubmed
Neumann M, Valori C, Ansorge O, Kretzschmar H, Munoz D, Kusaka H, et al. Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations. Acta Neuropathol. 2012;124:705-16 pubmed publisher
product information
CatalogNo :
60160-1-Ig
AntigenName :
FUS/TLS
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
fusion (involved in t(12;16) in malignant liposarcoma)
Immunogen :
Recombinant Protein
Species :
drosophila, human, mouse
Host :
Mouse
IsConjugated :
Unconjugated
AntigenSpecies :
human
CloneNo :
3A10B5
Application :
WB, IP, IHC, IF, FC, ELISA
Clonlity :
Monoclonal
IsoType :
IgG1
Synonyms :
75 kDa DNA pairing protein, FUS, FUS CHOP, FUS1, FUS-CHOP, hnRNP P2, Oncogene FUS, Oncogene TLS, POMp75, RNA binding protein FUS, TLS, TLS/CHOP
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC026062
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Neurology;Oncogene(s) and Tumor Suppressor(s);
PurifyMethod :
Protein G purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
FC 1:0 ; IF 1:100 ; IHC 1:1000 ; IP 1:10000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.