This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
IFITM1-Specific
catalog :
60074-1-Ig
quantity :
150UL
price :
299 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
5B5E2
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 30
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:5000; loading ...; fig s5f
Petrillo C, Thorne L, Unali G, Schiroli G, Giordano A, Piras F, et al. Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells. Cell Stem Cell. 2018;23:820-832.e9 pubmed publisher
  • western blot; human; loading ...; fig 4g
Shi G, OZOG S, Torbett B, Compton A. mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3. Proc Natl Acad Sci U S A. 2018;115:E10069-E10078 pubmed publisher
  • flow cytometry; human; loading ...; fig ev1a
Monel B, Compton A, Bruel T, Amraoui S, Burlaud Gaillard J, Roy N, et al. Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells. EMBO J. 2017;36:1653-1668 pubmed publisher
  • flow cytometry; human; 1:200; loading ...; fig 1e
Raposo R, de Mulder Rougvie M, Paquin Proulx D, Brailey P, Cabido V, Zdinak P, et al. IFITM1 targets HIV-1 latently infected cells for antibody-dependent cytolysis. JCI Insight. 2017;2:e85811 pubmed publisher
Zhao X, Zheng S, Chen D, Zheng M, Li X, Li G, et al. LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2. J Virol. 2020;94: pubmed publisher
Williams G, Gokhale N, Snider D, Horner S. The mRNA Cap 2'-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes. mSphere. 2020;5: pubmed publisher
Ahi Y, Yimer D, Shi G, Majdoul S, Rahman K, Rein A, et al. IFITM3 Reduces Retroviral Envelope Abundance and Function and Is Counteracted by glycoGag. MBio. 2020;11: pubmed publisher
Winkler M, Wrensch F, Bosch P, Knoth M, Schindler M, Gärtner S, et al. Analysis of IFITM-IFITM Interactions by a Flow Cytometry-Based FRET Assay. Int J Mol Sci. 2019;20: pubmed publisher
Buchrieser J, Degrelle S, Couderc T, Nevers Q, Disson O, Manet C, et al. IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise. Science. 2019;365:176-180 pubmed publisher
Lee W, Fu R, Liang C, Sloan R. IFITM proteins inhibit HIV-1 protein synthesis. Sci Rep. 2018;8:14551 pubmed publisher
Wang B, Lam T, Soh M, Ye Z, Chen J, Ren E. Influenza A Virus Facilitates Its Infectivity by Activating p53 to Inhibit the Expression of Interferon-Induced Transmembrane Proteins. Front Immunol. 2018;9:1193 pubmed publisher
Roesch F, OhAinle M, Emerman M. A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery. Retrovirology. 2018;15:26 pubmed publisher
Selman M, Ou P, Rousso C, Bergeron A, Krishnan R, Pikor L, et al. Dimethyl fumarate potentiates oncolytic virotherapy through NF-?B inhibition. Sci Transl Med. 2018;10: pubmed publisher
Selman M, Rousso C, Bergeron A, Son H, Krishnan R, El Sayes N, et al. Multi-modal Potentiation of Oncolytic Virotherapy by Vanadium Compounds. Mol Ther. 2018;26:56-69 pubmed publisher
Burchill M, Roby J, Crochet N, Wind Rotolo M, STONE A, Edwards M, et al. Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy. PLoS ONE. 2017;12:e0186213 pubmed publisher
Xu Yang Z, Pei Yu B, Chuan Tao Y, Wei Y, Hong Wei M, Kang T, et al. Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome. Front Immunol. 2016;7:535 pubmed publisher
Savidis G, Perreira J, Portmann J, Meraner P, Guo Z, Green S, et al. The IFITMs Inhibit Zika Virus Replication. Cell Rep. 2016;15:2323-30 pubmed publisher
Gao F, Liang H, Lu H, Wang J, Xia M, Yuan Z, et al. Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach. Clin Epigenetics. 2015;7:86 pubmed publisher
Xie M, Xuan B, Shan J, Pan D, Sun Y, Shan Z, et al. Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment. J Virol. 2015;89:3049-61 pubmed publisher
Compton A, Bruel T, Porrot F, Mallet A, Sachse M, Euvrard M, et al. IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread. Cell Host Microbe. 2014;16:736-47 pubmed publisher
Tartour K, Appourchaux R, Gaillard J, Nguyen X, Durand S, Turpin J, et al. IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity. Retrovirology. 2014;11:103 pubmed publisher
Wrensch F, Winkler M, Pöhlmann S. IFITM proteins inhibit entry driven by the MERS-coronavirus spike protein: evidence for cholesterol-independent mechanisms. Viruses. 2014;6:3683-98 pubmed publisher
Zhang W, Zhang L, Zan Y, Du N, Yang Y, Tien P. Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins. J Gen Virol. 2015;96:170-82 pubmed publisher
Zhu X, He Z, Yuan J, Wen W, Huang X, Hu Y, et al. IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection. Cell Microbiol. 2015;17:105-18 pubmed publisher
Zhao X, Guo F, Liu F, Cuconati A, Chang J, Block T, et al. Interferon induction of IFITM proteins promotes infection by human coronavirus OC43. Proc Natl Acad Sci U S A. 2014;111:6756-61 pubmed publisher
Lin T, Chin C, Everitt A, Clare S, Perreira J, Savidis G, et al. Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction. Cell Rep. 2013;5:895-908 pubmed publisher
John S, Chin C, Perreira J, Feeley E, Aker A, Savidis G, et al. The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication. J Virol. 2013;87:7837-52 pubmed publisher
Lau D, Negash A, Chen J, Crochet N, Sinha M, Zhang Y, et al. Innate immune tolerance and the role of kupffer cells in differential responses to interferon therapy among patients with HCV genotype 1 infection. Gastroenterology. 2013;144:402-413.e12 pubmed publisher
Wilkins C, Woodward J, Lau D, Barnes A, Joyce M, McFarlane N, et al. IFITM1 is a tight junction protein that inhibits hepatitis C virus entry. Hepatology. 2013;57:461-9 pubmed publisher
Brass A, Huang I, Benita Y, John S, Krishnan M, Feeley E, et al. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell. 2009;139:1243-54 pubmed publisher
product information
CatalogNo :
60074-1-Ig
AntigenName :
IFITM1-Specific
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
interferon induced transmembrane protein 1 (9-27)
Immunogen :
Recombinant Protein
Species :
human, mouse
Host :
Mouse
IsConjugated :
Unconjugated
AntigenSpecies :
human
CloneNo :
5B5E2
Application :
WB, IP, IHC, IF, FC, ELISA
Clonlity :
Monoclonal
IsoType :
IgG2a
Synonyms :
9 27, CD225, IFI17, IFITM1, Interferon induced protein 17, Leu 13 antigen, LEU13
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC000897
Category :
Binding Proteins;Cell Cycle;Disease Related;Immunology;Membrane Proteins;Signal transduction;
PurifyMethod :
Protein A purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IHC 1:500 ; IP 1:500 ; WB 1:50000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.