This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
KEAP1
catalog :
60027-1-Ig
quantity :
150UL
price :
299 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4G10H9
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
citations: 25
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 5b
Pinterić M, Podgorski I, Hadžija M, Bujak I, Dekanic A, Bagarić R, et al. Role of Sirt3 in Differential Sex-Related Responses to a High-Fat Diet in Mice. Antioxidants (Basel). 2020;9: pubmed publisher
  • western blot; human; 1:100; loading ...; fig 7a
Duleh S, Wang X, Komirenko A, Margeta M. Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies. Acta Neuropathol Commun. 2016;4:115 pubmed
  • western blot; mouse; fig 1d
Soares M, Cohen O, Low Y, Sartor R, Ellison T, Anil U, et al. Restoration of Nrf2 Signaling Normalizes the Regenerative Niche. Diabetes. 2016;65:633-46 pubmed publisher
  • western blot; human; loading ...; fig 3a,3c
Bakkar N, Kousari A, Kovalik T, Li Y, Bowser R. RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1. Mol Cell Biol. 2015;35:2385-99 pubmed publisher
  • western blot; rat; loading ...; fig 1b
Jimenez Blasco D, Santofimia Castaño P, Gonzalez A, Almeida A, Bolaños J. Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway. Cell Death Differ. 2015;22:1877-89 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; loading ...; fig 3c
Cescon D, She D, Sakashita S, Zhu C, Pintilie M, Shepherd F, et al. NRF2 Pathway Activation and Adjuvant Chemotherapy Benefit in Lung Squamous Cell Carcinoma. Clin Cancer Res. 2015;21:2499-505 pubmed publisher
  • western blot; human
Lee Y, Kwon S, An J, Kim C, Choi C, Nam D, et al. Increased protein oxidation and decreased expression of nuclear factor E2-related factor 2 protein in skin tissue of patients with diabetes. Clin Exp Dermatol. 2015;40:192-200 pubmed publisher
Chen Z, Xiao J, Liu H, Yao K, Hou X, Cao Y, et al. Astaxanthin attenuates oxidative stress and immune impairment in D-galactose-induced aging in rats by activating the Nrf2/Keap1 pathway and suppressing the NF-κB pathway. Food Funct. 2020;: pubmed publisher
Feng L, Zhao F, Liu Q, Peng J, Duan X, Yan P, et al. Role of Nrf2 in Lipopolysaccharide-Induced Acute Kidney Injury: Protection by Human Umbilical Cord Blood Mononuclear Cells. Oxid Med Cell Longev. 2020;2020:6123459 pubmed publisher
Wang Y, Lian M, Zhou J, Wu S. Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer's Disease Via Aβ42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2. Mol Neurobiol. 2020;: pubmed publisher
Yuan L, Li Q, Bai D, Shang X, Hu F, Chen Z, et al. La2O3 Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice. Int J Nanomedicine. 2020;15:3415-3431 pubmed publisher
Zhao X, Shi Y, Zhang D, Tong X, Sun Y, Xue X, et al. Autophagy inducer activates Nrf2-ARE pathway to attenuate aberrant alveolarization in neonatal rats with bronchopulmonary dysplasia. Life Sci. 2020;252:117662 pubmed publisher
Xu C, Hou B, He P, Ma P, Yang X, Yang X, et al. Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2. Oxid Med Cell Longev. 2020;2020:6431459 pubmed publisher
Zheng D, Liu Z, Zhou Y, Hou N, Yan W, Qin Y, et al. Urolithin B, a gut microbiota metabolite, protects against myocardial ischemia/reperfusion injury via p62/Keap1/Nrf2 signaling pathway. Pharmacol Res. 2020;153:104655 pubmed publisher
Han J, Guo D, Sun X, Wang J, Ouyang J, Gui B. Repair Effects of Astragalus Polysaccharides with Different Molecular Weights on Oxidatively Damaged HK-2 Cells. Sci Rep. 2019;9:9871 pubmed publisher
Rabbani P, Soares M, Hameedi S, Kadle R, Mubasher A, Kowzun M, et al. Dysregulation of Nrf2/Keap1 Redox Pathway in Diabetes Affects Multipotency of Stromal Cells. Diabetes. 2019;68:141-155 pubmed publisher
Wijdeven R, van Luijn M, Wierenga Wolf A, Akkermans J, van den Elsen P, Hintzen R, et al. Chemical and genetic control of IFNγ-induced MHCII expression. EMBO Rep. 2018;19: pubmed publisher
Rabbani P, Zhou A, Borab Z, Frezzo J, Srivastava N, More H, et al. Novel lipoproteoplex delivers Keap1 siRNA based gene therapy to accelerate diabetic wound healing. Biomaterials. 2017;132:1-15 pubmed publisher
Lee Y, Kwon S, Kim C, Cho H, Nam H, Lee S, et al. Oxidative Damage and Nuclear Factor Erythroid 2-Related Factor 2 Protein Expression in Normal Skin and Keloid Tissue. Ann Dermatol. 2015;27:507-16 pubmed publisher
Huang C, Deng W, Zhang L, Zhang W, Sun Z. Expression of LC3, LAMP2, KEAP1 and NRF2 in Salivary Adenoid Cystic Carcinoma. Pathol Oncol Res. 2016;22:109-14 pubmed publisher
Choi C, Kim J, Wee S, Lee J, Nam D, Kim C, et al. Expression of nuclear factor erythroid 2 protein in malignant cutaneous tumors. Arch Plast Surg. 2014;41:654-60 pubmed publisher
Zhao F, Li K, Zhao L, Liu J, Suo Q, Zhao J, et al. Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response. Int J Clin Exp Pathol. 2014;7:2780-9 pubmed
Huang C, Zhang L, Ma S, Zhao Z, Wang W, He K, et al. Clinical significance of Keap1 and Nrf2 in oral squamous cell carcinoma. PLoS ONE. 2013;8:e83479 pubmed publisher
Chandiramani N, Wang X, Margeta M. Molecular basis for vulnerability to mitochondrial and oxidative stress in a neuroendocrine CRI-G1 cell line. PLoS ONE. 2011;6:e14485 pubmed publisher
Lee D, Kuo H, Liu M, Chou C, Xia W, Du Y, et al. KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol Cell. 2009;36:131-40 pubmed publisher
product information
CatalogNo :
60027-1-Ig
AntigenName :
KEAP1
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
kelch-like ECH-associated protein 1
Immunogen :
Recombinant Protein
Species :
human, mouse, rat
Host :
Mouse
IsConjugated :
Unconjugated
AntigenSpecies :
human
CloneNo :
4G10H9
Application :
WB, IHC, IF, CoIP, ELISA
Clonlity :
Monoclonal
IsoType :
IgA
Synonyms :
Cytosolic inhibitor of Nrf2, INrf2, KEAP1, Kelch like protein 19, KIAA0132, KLHL19
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC002930
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Disease Related;Membrane Proteins;Metabolism;
PurifyMethod :
Thiophilic affinity chromatograph
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IHC 1:50 ; WB 1:2000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.