| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; loading ...; fig 14a
| Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach T, et al. Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes. Hum Mol Genet. 2017;26:969-988 pubmed publisher |
- immunocytochemistry; human; 1:500; loading ...; fig 5c
| Smethurst P, Newcombe J, Troakes C, Simone R, Chen Y, Patani R, et al. In vitro prion-like behaviour of TDP-43 in ALS. Neurobiol Dis. 2016;96:236-247 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 3a
| Homma S, Beermann M, BOYCE F, Miller J. Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregation. Ann Clin Transl Neurol. 2015;2:151-66 pubmed publisher |
- immunocytochemistry; human; 1:200; fig 3
| Herdewyn S, Cirillo C, Van Den Bosch L, Robberecht W, Vanden Berghe P, Van Damme P. Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice. Mol Neurodegener. 2014;9:24 pubmed publisher |
| Ho W, Chang J, Lim K, Cazenave Gassiot A, Nguyen A, Foo J, et al. TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination. J Cell Biol. 2021;220: pubmed publisher |
| Collins M, Li Y, Bowser R. RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases. Acta Neuropathol Commun. 2020;8:91 pubmed publisher |
| Chan G, Van Hummel A, van der Hoven J, Ittner L, Ke Y. Neurodegeneration and Motor Deficits in the Absence of Astrogliosis upon Transgenic Mutant TDP-43 Expression in Mature Mice. Am J Pathol. 2020;190:1713-1722 pubmed publisher |
| Romano N, Catalani A, Lattante S, Belardo A, Proietti S, Bertini L, et al. ALS skin fibroblasts reveal oxidative stress and ERK1/2-mediated cytoplasmic localization of TDP-43. Cell Signal. 2020;70:109591 pubmed publisher |
| Sproviero D, La Salvia S, Colombo F, Zucca S, Pansarasa O, Diamanti L, et al. Leukocyte Derived Microvesicles as Disease Progression Biomarkers in Slow Progressing Amyotrophic Lateral Sclerosis Patients. Front Neurosci. 2019;13:344 pubmed publisher |
| Jiang T, Handley E, Brizuela M, Dawkins E, Lewis K, Clark R, et al. Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function. Dis Model Mech. 2019;12: pubmed publisher |
| Coudert L, Nonaka T, Bernard E, Hasegawa M, Schaeffer L, Leblanc P. Phosphorylated and aggregated TDP-43 with seeding properties are induced upon mutant Huntingtin (mHtt) polyglutamine expression in human cellular models. Cell Mol Life Sci. 2019;76:2615-2632 pubmed publisher |
| Laferrière F, Maniecka Z, Pérez Berlanga M, Hruska Plochan M, Gilhespy L, Hock E, et al. TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates. Nat Neurosci. 2019;22:65-77 pubmed publisher |
| Gordon D, Dafinca R, Scaber J, Alegre Abarrategui J, Farrimond L, Scott C, et al. Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction. Neurobiol Dis. 2019;121:148-162 pubmed publisher |
| Bain H, Davidson Y, Robinson A, Ryan S, Rollinson S, Richardson A, et al. The role of lysosomes and autophagosomes in frontotemporal lobar degeneration. Neuropathol Appl Neurobiol. 2019;45:244-261 pubmed publisher |
| Sproviero D, La Salvia S, Giannini M, Crippa V, Gagliardi S, Bernuzzi S, et al. Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients. Front Neurosci. 2018;12:487 pubmed publisher |
| Conlon E, Fagegaltier D, Agius P, Davis Porada J, Gregory J, Hubbard I, et al. Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism. elife. 2018;7: pubmed publisher |
| Scherz B, Rabl R, Flunkert S, Rohler S, Neddens J, Taub N, et al. mTh1 driven expression of hTDP-43 results in typical ALS/FTLD neuropathological symptoms. PLoS ONE. 2018;13:e0197674 pubmed publisher |
| Volkening K, Keller B, Leystra Lantz C, Strong M. RNA and Protein Interactors with TDP-43 in Human Spinal-Cord Lysates in Amyotrophic Lateral Sclerosis. J Proteome Res. 2018;17:1712-1729 pubmed publisher |
| Wang A, Conicella A, Schmidt H, Martin E, Rhoads S, Reeb A, et al. A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing. EMBO J. 2018;37: pubmed publisher |
| Liu G, Coyne A, Pei F, Vaughan S, Chaung M, Zarnescu D, et al. Endocytosis regulates TDP-43 toxicity and turnover. Nat Commun. 2017;8:2092 pubmed publisher |
| Watanabe R, Kawakami I, Onaya M, Higashi S, Arai N, Akiyama H, et al. Frontotemporal dementia with trans-activation response DNA-binding protein 43 presenting with catatonic syndrome. Neuropathology. 2018;38:281-287 pubmed publisher |
| Foglieni C, Papin S, Salvade A, Afroz T, Pinton S, Pedrioli G, et al. Split GFP technologies to structurally characterize and quantify functional biomolecular interactions of FTD-related proteins. Sci Rep. 2017;7:14013 pubmed publisher |
| Alfieri J, Silva P, Igaz L. Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice. Front Aging Neurosci. 2016;8:310 pubmed publisher |
| Tan R, Ke Y, Ittner L, Halliday G. ALS/FTLD: experimental models and reality. Acta Neuropathol. 2017;133:177-196 pubmed publisher |
| Homma S, Beermann M, Yu B, BOYCE F, Miller J. Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4. Skelet Muscle. 2016;6:42 pubmed |
| Handley E, Pitman K, Dawkins E, Young K, Clark R, Jiang T, et al. Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies. Cereb Cortex. 2017;27:3630-3647 pubmed publisher |
| Shiihashi G, Ito D, Yagi T, Nihei Y, Ebine T, Suzuki N. Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice. Brain. 2016;139:2380-94 pubmed publisher |
| Koyama A, Sugai A, Kato T, Ishihara T, Shiga A, Toyoshima Y, et al. Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43. Nucleic Acids Res. 2016;44:5820-36 pubmed publisher |
| Kametani F, Obi T, Shishido T, Akatsu H, Murayama S, Saito Y, et al. Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains. Sci Rep. 2016;6:23281 pubmed publisher |
| Tanaka Y, Nonaka T, Suzuki G, Kametani F, Hasegawa M. Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation. Hum Mol Genet. 2016;25:1420-33 pubmed publisher |
| Shimonaka S, Nonaka T, Suzuki G, Hisanaga S, Hasegawa M. Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils. J Biol Chem. 2016;291:8896-907 pubmed publisher |
| Henriques A, Croixmarie V, Priestman D, Rosenbohm A, Dirrig Grosch S, D Ambra E, et al. Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase. Hum Mol Genet. 2015;24:7390-405 pubmed publisher |
| Ke Y, Van Hummel A, Stevens C, Gladbach A, Ippati S, Bi M, et al. Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS. Acta Neuropathol. 2015;130:661-78 pubmed publisher |
| Bakkar N, Kousari A, Kovalik T, Li Y, Bowser R. RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1. Mol Cell Biol. 2015;35:2385-99 pubmed publisher |
| Goossens J, Vanmechelen E, Trojanowski J, Lee V, Van Broeckhoven C, van der Zee J, et al. TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies. Acta Neuropathol Commun. 2015;3:15 pubmed publisher |
| Cohen T, Hwang A, Restrepo C, Yuan C, Trojanowski J, Lee V. An acetylation switch controls TDP-43 function and aggregation propensity. Nat Commun. 2015;6:5845 pubmed publisher |
| Mutihac R, Alegre Abarrategui J, Gordon D, Farrimond L, Yamasaki Mann M, Talbot K, et al. TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca²⺠signaling in motor neurons. Neurobiol Dis. 2015;75:64-77 pubmed publisher |
| Yamakawa M, Ito D, Honda T, Kubo K, Noda M, Nakajima K, et al. Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS. Hum Mol Genet. 2015;24:1630-45 pubmed publisher |
| Osaka M, Ito D, Yagi T, Nihei Y, Suzuki N. Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis. Hum Mol Genet. 2015;24:1617-29 pubmed publisher |
| Alfieri J, Pino N, Igaz L. Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies. J Neurosci. 2014;34:15244-59 pubmed publisher |
| Yamashita M, Nonaka T, Hirai S, Miwa A, Okado H, Arai T, et al. Distinct pathways leading to TDP-43-induced cellular dysfunctions. Hum Mol Genet. 2014;23:4345-56 pubmed publisher |
| Suarez Calvet M, Dols Icardo O, Lladó A, Sanchez Valle R, Hernandez I, Amer G, et al. Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation. J Neurol Neurosurg Psychiatry. 2014;85:684-91 pubmed publisher |
| Akamatsu M, Takuma H, Yamashita T, Okada T, Keino Masu K, Ishii K, et al. A unique mouse model for investigating the properties of amyotrophic lateral sclerosis-associated protein TDP-43, by in utero electroporation. Neurosci Res. 2013;77:234-41 pubmed publisher |
| Hosokawa M, Arai T, Yamashita M, Tsuji H, Nonaka T, Masuda Suzukake M, et al. Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid. Int J Neurosci. 2014;124:344-9 pubmed publisher |
| Stallings N, Puttaparthi K, Dowling K, Luther C, Burns D, Davis K, et al. TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis. PLoS ONE. 2013;8:e71793 pubmed publisher |
| Nonaka T, Masuda Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, et al. Prion-like properties of pathological TDP-43 aggregates from diseased brains. Cell Rep. 2013;4:124-34 pubmed publisher |
| Nakamura S, Wate R, Kaneko S, Ito H, Oki M, Tsuge A, et al. An autopsy case of sporadic amyotrophic lateral sclerosis associated with the I113T SOD1 mutation. Neuropathology. 2014;34:58-63 pubmed publisher |
| Larman H, Salajegheh M, Nazareno R, Lam T, Sauld J, Steen H, et al. Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis. Ann Neurol. 2013;73:408-18 pubmed publisher |
| Zhang Y, Caulfield T, Xu Y, Gendron T, Hubbard J, Stetler C, et al. The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation. Hum Mol Genet. 2013;22:3112-22 pubmed publisher |
| Cassel J, Reitz A. Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines. Biochim Biophys Acta. 2013;1834:964-71 pubmed publisher |
| Tsuji H, Arai T, Kametani F, Nonaka T, Yamashita M, Suzukake M, et al. Molecular analysis and biochemical classification of TDP-43 proteinopathy. Brain. 2012;135:3380-91 pubmed publisher |
| González Pérez P, Lu Y, Chian R, Sapp P, Tanzi R, Bertram L, et al. Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS. Neurobiol Dis. 2012;48:391-8 pubmed publisher |
| Dammer E, Fallini C, Gozal Y, Duong D, Rossoll W, Xu P, et al. Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination. PLoS ONE. 2012;7:e38658 pubmed publisher |
| Inamori Y, Higuchi I, Inoue T, Sakiyama Y, Hashiguchi A, Higashi K, et al. Inclusion body myositis coexisting with hypertrophic cardiomyopathy: an autopsy study. Neuromuscul Disord. 2012;22:747-54 pubmed publisher |
| Cohen T, Hwang A, Unger T, Trojanowski J, Lee V. Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking. EMBO J. 2012;31:1241-52 pubmed publisher |
| Tsuji H, Nonaka T, Yamashita M, Masuda Suzukake M, Kametani F, Akiyama H, et al. Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Biochem Biophys Res Commun. 2012;417:116-21 pubmed publisher |
| Necchi D, Lomoio S, Scherini E. Dysfunction of the ubiquitin-proteasome system in the cerebellum of aging Ts65Dn mice. Exp Neurol. 2011;232:114-8 pubmed publisher |
| Deng H, Chen W, Hong S, Boycott K, Gorrie G, Siddique N, et al. Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature. 2011;477:211-5 pubmed publisher |
| Suzuki S, Tamai K, Watanabe M, Kyuuma M, Ono M, Sugamura K, et al. AMSH is required to degrade ubiquitinated proteins in the central nervous system. Biochem Biophys Res Commun. 2011;408:582-8 pubmed publisher |
| Igaz L, Kwong L, Lee E, Chen Plotkin A, Swanson E, Unger T, et al. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. J Clin Invest. 2011;121:726-38 pubmed publisher |
| Deng H, Zhai H, Bigio E, Yan J, Fecto F, Ajroud K, et al. FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis. Ann Neurol. 2010;67:739-48 pubmed publisher |
| Nishimoto Y, Ito D, Yagi T, Nihei Y, Tsunoda Y, Suzuki N. Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43. J Biol Chem. 2010;285:608-19 pubmed publisher |
| Steinacker P, Hendrich C, Sperfeld A, Jesse S, von Arnim C, Lehnert S, et al. TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Arch Neurol. 2008;65:1481-7 pubmed publisher |
| Rohn T. Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease. Brain Res. 2008;1228:189-98 pubmed publisher |
| Kim H, Fan X, Gabbi C, Yakimchuk K, Parini P, Warner M, et al. Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia. Proc Natl Acad Sci U S A. 2008;105:2094-9 pubmed publisher |
| Lee E, Lee V, Trojanowski J, Neumann M. TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system. Acta Neuropathol. 2008;115:305-11 pubmed |
