This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
Caspase 12
catalog :
55238-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 47
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 5a
Yue X, Zuo Y, Ke H, Luo J, Lou L, Qin W, et al. Identification of 4-arylidene curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase. Biochem Pharmacol. 2017;137:29-50 pubmed publisher
Zhao H, Wang Y, Li B, Zheng T, Liu X, Hu B, et al. Role of Endoplasmic Reticulum Stress in Otitis Media. Front Genet. 2020;11:495 pubmed publisher
Yang B, Qin Q, Xu L, Lv X, Liu Z, Song E, et al. Polychlorinated Biphenyl Quinone Promotes Atherosclerosis through Lipid Accumulation and Endoplasmic Reticulum Stress via CD36. Chem Res Toxicol. 2020;33:1497-1507 pubmed publisher
Zhang J, Yao D, Song Y, Pan Y, Zhu L, Bai Y, et al. Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility. Sci Rep. 2019;9:15221 pubmed publisher
Zheng Y, Liu P, Wang N, Wang S, Yang B, Li M, et al. Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway. Oxid Med Cell Longev. 2019;2019:8781690 pubmed publisher
Liao Z, Luo R, Li G, Song Y, Zhan S, Zhao K, et al. Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo. Theranostics. 2019;9:4084-4100 pubmed publisher
Ye J, Qi L, Chen K, Li R, Song S, Zhou C, et al. Metformin induces TPC-1 cell apoptosis through endoplasmic reticulum stress-associated pathways in vitro and in vivo. Int J Oncol. 2019;55:331-339 pubmed publisher
Tang S, Wang J, Liu J, Huang Y, Zhou Y, Yang S, et al. Niban protein regulates apoptosis in HK-2 cells via caspase-dependent pathway. Ren Fail. 2019;41:455-466 pubmed publisher
Li H, Zhao W, Wang L, Luo Q, Yin N, Lu X, et al. Human placenta-derived mesenchymal stem cells inhibit apoptosis of granulosa cells induced by IRE1α pathway in autoimmune POF mice. Cell Biol Int. 2019;: pubmed publisher
Sun X, Huang X, Zhu X, Liu L, Mo S, Wang H, et al. HBOA ameliorates CCl4-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways. Biomed Pharmacother. 2019;115:108901 pubmed publisher
Zhao Y, Yan J, Li A, Zhang Z, Li Z, Guo K, et al. Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats. Toxicol Lett. 2019;310:31-38 pubmed publisher
Shah S, Zhao D, Taglialatela G, Hussain T, Dong H, Sabir N, et al. Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway. Int J Mol Sci. 2019;20: pubmed publisher
Cui J, Liu Y, Chang X, Gou W, Zhou X, Liu Z, et al. Acetaldehyde Induces Neurotoxicity In Vitro via Oxidative Stress- and Ca2+ Imbalance-Mediated Endoplasmic Reticulum Stress. Oxid Med Cell Longev. 2019;2019:2593742 pubmed publisher
Liu P, Zhang H, Hu K, Zhou X, Tang S. Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia. J Cell Physiol. 2019;234:13534-13543 pubmed publisher
Li Z, Rong L, Lian H, Cheng J, Wu X, Li X. Knockdown MTMR14 promotes cell apoptosis and inhibits migration in liver cancer cells. Gene. 2019;691:106-113 pubmed publisher
Li S, Jiang Z, Chai W, Xu Y, Wang Y. Autophagy activation alleviates nonylphenol-induced apoptosis in cultured cortical neurons. Neurochem Int. 2019;122:73-84 pubmed publisher
Niu X, Zhang J, Ni J, Wang R, Zhang W, Sun S, et al. Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction. Biosci Rep. 2018;38: pubmed publisher
Liao D, Xiang D, Dang R, Xu P, Wang J, Han W, et al. Neuroprotective Effects of dl-3-n-Butylphthalide against Doxorubicin-Induced Neuroinflammation, Oxidative Stress, Endoplasmic Reticulum Stress, and Behavioral Changes. Oxid Med Cell Longev. 2018;2018:9125601 pubmed publisher
He Q, Zhou X, Liu Y, Gou W, Cui J, Li Z, et al. Titanium dioxide nanoparticles induce mouse hippocampal neuron apoptosis via oxidative stress- and calcium imbalance-mediated endoplasmic reticulum stress. Environ Toxicol Pharmacol. 2018;63:6-15 pubmed publisher
Li P, Liu L, Zhou G, Tian Z, Luo C, Xia T, et al. Perigestational exposure to low doses of PBDE-47 induces excessive ER stress, defective autophagy and the resultant apoptosis contributing to maternal thyroid toxicity. Sci Total Environ. 2018;645:363-371 pubmed publisher
Cai Y, Zheng Y, Gu J, Wang S, Wang N, Yang B, et al. Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78. Cell Death Dis. 2018;9:636 pubmed publisher
Li Z, Meng Z, Lu J, Chen F, Wong W, Tse G, et al. TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2018;120:1-11 pubmed publisher
Kawaguchi N, Tashiro K, Taniguchi K, Kawai M, Tanaka K, Okuda J, et al. Nogo-B (Reticulon-4B) functions as a negative regulator of the apoptotic pathway through the interaction with c-FLIP in colorectal cancer cells. Biochim Biophys Acta Mol Basis Dis. 2018;1864:2600-2609 pubmed publisher
Zhou G, Li A, Sun Y, Sun G. A novel synthetic curcumin derivative MHMM-41 induces ROS-mediated apoptosis and migration blocking of human lung cancer cells A549. Biomed Pharmacother. 2018;103:391-398 pubmed publisher
Wang Z, Cui R, Wang K. Effects of sevoflurane pretreatment on the apoptosis of rat H9c2 cardiomyocytes and the expression of GRP78. Exp Ther Med. 2018;15:2818-2823 pubmed publisher
Niu X, Zhang J, Ling C, Bai M, Peng Y, Sun S, et al. Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway. J Int Med Res. 2018;46:1717-1733 pubmed publisher
Niu Q, Chen J, Xia T, Li P, Zhou G, Xu C, et al. Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity. Environ Pollut. 2018;233:889-899 pubmed publisher
Sun W, Yang J, Zhang Y, Xi Y, Wen X, Yuan D, et al. Exogenous H2S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes. Cell Biosci. 2017;7:67 pubmed publisher
Zong S, Liu T, Wan F, Chen P, Luo P, Xiao H. Endoplasmic Reticulum Stress Is Involved in Cochlear Cell Apoptosis in a Cisplatin-Induced Ototoxicity Rat Model. Audiol Neurootol. 2017;22:160-168 pubmed publisher
Liu Z, Wang Y, Wang Y, Dong W, Xia X, Song E, et al. Effect of Subcellular Translocation of Protein Disulfide Isomerase on Tetrachlorobenzoquinone-Induced Signaling Shift from Endoplasmic Reticulum Stress to Apoptosis. Chem Res Toxicol. 2017;30:1804-1814 pubmed publisher
Xu Z, Lu Y, Wang J, Ding X, Chen J, Miao C. The protective effect of propofol against TNF-α-induced apoptosis was mediated via inhibiting iNOS/NO production and maintaining intracellular Ca2+ homeostasis in mouse hippocampal HT22 cells. Biomed Pharmacother. 2017;91:664-672 pubmed publisher
Wang Y, Gu Y, Liu M, Bai Y, Liang L, Wang H. TBHQ Alleviated Endoplasmic Reticulum Stress-Apoptosis and Oxidative Stress by PERK-Nrf2 Crosstalk in Methamphetamine-Induced Chronic Pulmonary Toxicity. Oxid Med Cell Longev. 2017;2017:4310475 pubmed publisher
Shah S, Zhao D, Taglialatela G, Khan S, Hussain T, Dong H, et al. Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters. Neurotherapeutics. 2017;14:463-483 pubmed publisher
Gu Y, Wang Y, Bai Y, Liu M, Wang H. Endoplasmic reticulum stress and apoptosis via PERK-eIF2?-CHOP signaling in the methamphetamine-induced chronic pulmonary injury. Environ Toxicol Pharmacol. 2017;49:194-201 pubmed publisher
Lu W, Kang J, Hu K, Tang S, Zhou X, Yu S, et al. Angiotensin-(1-7) relieved renal injury induced by chronic intermittent hypoxia in rats by reducing inflammation, oxidative stress and fibrosis. Braz J Med Biol Res. 2017;50:e5594 pubmed publisher
Cui Y, Zhao D, Sreevatsan S, Liu C, Yang W, Song Z, et al. Mycobacterium bovis Induces Endoplasmic Reticulum Stress Mediated-Apoptosis by Activating IRF3 in a Murine Macrophage Cell Line. Front Cell Infect Microbiol. 2016;6:182 pubmed publisher
Yang F, Yu X, Li T, Wu J, Zhao Y, Liu J, et al. Exogenous H2S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes. Am J Physiol Endocrinol Metab. 2017;312:E190-E203 pubmed publisher
Wu H, Wang Y, Wu C, Yang P, Li H, Li Z. Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission. J Agric Food Chem. 2016;64:9356-9367 pubmed
Yuan G, Hua B, Yang Y, Xu L, Cai T, Sun N, et al. The Circadian Gene Clock Regulates Bone Formation Via PDIA3. J Bone Miner Res. 2017;32:861-871 pubmed publisher
Wang C, Zhang S, Ma R, Zhang X, Zhang C, Li B, et al. Roles of endoplasmic reticulum stress, apoptosis and autophagy in 2,2',4,4'-tetrabromodiphenyl ether-induced rat ovarian injury. Reprod Toxicol. 2016;65:187-193 pubmed publisher
Khan S, Zhao D, Shah S, Hassan M, Zhu T, Song Z, et al. Parkin Overexpression Ameliorates PrP106-126-Induced Neurotoxicity via Enhanced Autophagy in N2a Cells. Cell Mol Neurobiol. 2017;37:717-728 pubmed publisher
Peng P, Wu W, Zhao J, Song S, Wang X, Jia D, et al. Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer. Sci Rep. 2016;6:29604 pubmed publisher
Wang C, Li T, Tang S, Zhao D, Zhang C, Zhang S, et al. Thapsigargin induces apoptosis when autophagy is inhibited in HepG2 cells and both processes are regulated by ROS-dependent pathway. Environ Toxicol Pharmacol. 2016;41:167-79 pubmed publisher
Koubková L, Vyzula R, Karban J, Pinkas J, Ondrousková E, Vojtesek B, et al. Evaluation of cytotoxic activity of titanocene difluorides and determination of their mechanism of action in ovarian cancer cells. Invest New Drugs. 2015;33:1123-32 pubmed publisher
Zhou G, Cao F, Du S. The apoptotic pathways in the curcumin analog MHMD-induced lung cancer cell death and the essential role of actin polymerization during apoptosis. Biomed Pharmacother. 2015;71:128-34 pubmed publisher
Xu D, Su C, Song X, Shi Q, Fu J, Hu L, et al. Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release. Chem Res Toxicol. 2015;28:1326-37 pubmed publisher
Huang Y, Du Y, Zhang X, Bai L, Mibrahim M, Zhang J, et al. Down-regulated expression of Annexin A7 induces apoptosis in mouse hepatocarcinoma cell line by the intrinsic mitochondrial pathway. Biomed Pharmacother. 2015;70:146-50 pubmed publisher
product information
CatalogNo :
55238-1-AP
AntigenName :
Caspase 12
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
caspase 12 (gene/pseudogene)
Immunogen :
Peptide
Species :
hamster, hamsters, human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
CASP 12, CASP12, CASP12P1, caspase 12 (gene/pseudogene), Caspase12, Inactive caspase 12
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
NR_000035
Category :
Apoptosis;Binding Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
AppTiter :
IF 1:50 ; IHC 1:200 ; IP 1:1000 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.