This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
ATF6
catalog :
24169-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 68
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:2000; loading ...; fig s5a
Zhu P, Khatiwada S, Cui Y, Reineke L, Dooling S, Kim J, et al. Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome. Science. 2019;366:843-849 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Schiattarella G, Altamirano F, Tong D, French K, Villalobos E, Kim S, et al. Nitrosative stress drives heart failure with preserved ejection fraction. Nature. 2019;568:351-356 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Yue X, Zuo Y, Ke H, Luo J, Lou L, Qin W, et al. Identification of 4-arylidene curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase. Biochem Pharmacol. 2017;137:29-50 pubmed publisher
  • western blot; rat; 1:5000; loading ...; fig 7a
Kim J, Ko A, Hyun H, Min S, Kim J. PDI regulates seizure activity via NMDA receptor redox in rats. Sci Rep. 2017;7:42491 pubmed publisher
  • western blot; mouse; fig 4
Lin Y, Zhuang J, Li H, Zhu G, Zhou S, Li W, et al. Vaspin attenuates the progression of atherosclerosis by inhibiting ER stress-induced macrophage apoptosis in apoE‑/‑ mice. Mol Med Rep. 2016;13:1509-16 pubmed publisher
Su W, Tai Y, Tang S, Ye Y, Zhao C, Gao J, et al. Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats. World J Gastroenterol. 2020;26:4094-4107 pubmed publisher
Zhang D, Fan R, Lei L, Lei L, Wang Y, Lv N, et al. Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21Cip1 and p27Kip1. J Cell Mol Med. 2020;: pubmed publisher
Pang X, Qiao Q, Vonglorkham S, Feng Z, Pang L, Chen S, et al. Asiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy. Biomed Pharmacother. 2020;129:110375 pubmed publisher
Zhao H, Wang Y, Li B, Zheng T, Liu X, Hu B, et al. Role of Endoplasmic Reticulum Stress in Otitis Media. Front Genet. 2020;11:495 pubmed publisher
Liu H, Xie S, Fang F, Kalvakolanu D, Xiao W. SHQ1 is an ER stress response gene that facilitates chemotherapeutics-induced apoptosis via sensitizing ER-stress response. Cell Death Dis. 2020;11:445 pubmed publisher
Yuan Q, Xu T, Chen Y, Qu W, Sun D, Liu X, et al. MiR-185-5p ameliorates endoplasmic reticulum stress and renal fibrosis by downregulation of ATF6. Lab Invest. 2020;: pubmed publisher
Zeng Z, Zheng Q, Chen J, Tan X, Li Q, Ding L, et al. FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis. Exp Cell Res. 2020;393:112108 pubmed publisher
Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, et al. Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor. Redox Biol. 2020;32:101514 pubmed publisher
Samanta S, Tamura S, Dubeau L, Mhawech Fauceglia P, Miyagi Y, Kato H, et al. Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma. Sci Rep. 2020;10:2160 pubmed publisher
YAO Y. Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling. Mol Med Rep. 2020;21:1059-1070 pubmed publisher
Wang Z, Chang L, Wu J, Pan H, Zhang Q, Wang M, et al. A novel rhynchophylline analog, Y396, inhibits endothelial dysfunction induced by oxidative stress in diabetes through EGF receptor. Antioxid Redox Signal. 2019;: pubmed publisher
Huang C, Hedl M, Ranjan K, Abraham C. LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes. Cell Rep. 2019;29:4525-4539.e4 pubmed publisher
Gao P, Chai Y, Song J, Liu T, Chen P, Zhou L, et al. Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus. PLoS Pathog. 2019;15:e1008169 pubmed publisher
Cheng F, Lee Y, Hsu Y, Chiu I, Chiu Y, Lin Y, et al. Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1. Aging (Albany NY). 2019;11:9875-9892 pubmed publisher
Ma Y, Di Z, Cao Q, Xu W, Bi S, Yu J, et al. Xanthatin induces glioma cell apoptosis and inhibits tumor growth via activating endoplasmic reticulum stress-dependent CHOP pathway. Acta Pharmacol Sin. 2019;: pubmed publisher
Tang Q, Ren L, Liu J, Li W, Zheng X, Wang J, et al. Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis. Cell Prolif. 2019;:e12706 pubmed publisher
Hu J, Wu Q, Wang Z, Hong J, Chen R, Li B, et al. Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress. Biomed Pharmacother. 2019;120:109475 pubmed publisher
Chen J, Hung C, Keller J, Lin H, Wu Y. Proteomic analysis of retinal pigment epithelium cells after exposure to UVA radiation. BMC Ophthalmol. 2019;19:168 pubmed publisher
Li C, Pan Y, Gao Y, Shi F, Wang Y, Sun X. Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity. Apoptosis. 2019;24:812-825 pubmed publisher
Nan D, Jin H, Deng J, Yu W, Liu R, Sun W, et al. Cilostazol ameliorates ischemia/reperfusion-induced tight junction disruption in brain endothelial cells by inhibiting endoplasmic reticulum stress. FASEB J. 2019;33:10152-10164 pubmed publisher
Xu W, Wu Y, Hu Z, Sun L, Dou G, Zhang Z, et al. Exosomes from Microglia Attenuate Photoreceptor Injury and Neovascularization in an Animal Model of Retinopathy of Prematurity. Mol Ther Nucleic Acids. 2019;16:778-790 pubmed publisher
Sun J, Liu Y, Yu J, Wu J, Gao W, Ran L, et al. Effects of APS Activates Hepatic Insulin Signaling in HFD-induced IR Mice. J Mol Endocrinol. 2019;: pubmed publisher
Wu Y, Su T, Dai G, Su J, Liu C. Flaccidoxide-13-Acetate-Induced Apoptosis in Human Bladder Cancer Cells is through Activation of p38/JNK, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress Regulated Pathway. Mar Drugs. 2019;17: pubmed publisher
Zhao Y, Yan J, Li A, Zhang Z, Li Z, Guo K, et al. Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats. Toxicol Lett. 2019;310:31-38 pubmed publisher
Guo Q, Hu H, Liu X, Yang D, Yin Y, Zhang B, et al. C/EBPβ mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes. Am J Physiol Endocrinol Metab. 2019;316:E1081-E1092 pubmed publisher
Wu S, Zhu X, Guo B, Zheng T, Ren J, Zeng W, et al. Unfolded Protein Response Pathways Correlatively Modulate Endoplasmic Reticulum Stress Responses in Rat Retinal Müller Cells. J Ophthalmol. 2019;2019:9028483 pubmed publisher
Cao X, He Y, Li X, Xu Y, Liu X. The IRE1α-XBP1 pathway function in hypoxia-induced pulmonary vascular remodeling, is upregulated by quercetin, inhibits apoptosis and partially reverses the effect of quercetin in PASMCs. Am J Transl Res. 2019;11:641-654 pubmed
Hsu Y, Chuang H, Lee Y, Lin Y, Chen Y, Hsiao T, et al. Traffic-related particulate matter exposure induces nephrotoxicity in vitro and in vivo. Free Radic Biol Med. 2019;135:235-244 pubmed publisher
Zhang L, Wang B, Xin Q, Shang W, Shen S, Xiao G, et al. Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection. J Virol. 2019;93: pubmed publisher
Huang C, Yao R, Zhu Z, Pang D, Cao X, Feng B, et al. A pectic polysaccharide from water decoction of Xinjiang Lycium barbarum fruit protects against intestinal endoplasmic reticulum stress. Int J Biol Macromol. 2019;130:508-514 pubmed publisher
Xu S, Di Z, He Y, Wang R, Ma Y, Sun R, et al. Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress. J Neuroinflammation. 2019;16:35 pubmed publisher
Zhou M, Feng Z, Ou Y, Peng J, Li K, Gong H, et al. Endoplasmic reticulum stress induces apoptosis of arginine vasopressin neurons in central diabetes insipidus via PI3K/Akt pathway. CNS Neurosci Ther. 2019;25:562-574 pubmed publisher
Blackwood E, Azizi K, Thuerauf D, Paxman R, Plate L, Kelly J, et al. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nat Commun. 2019;10:187 pubmed publisher
Ullah O, Li Z, Ali I, Xu L, Liu H, Jin H, et al. Pterostilbene exerts a protective effect via regulating tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos. In Vitro Cell Dev Biol Anim. 2019;55:82-93 pubmed publisher
Hong J, Hu Z, Wu Q, Tang C, Hu J, Chen R, et al. The deregulation of STIM1 and store operative calcium entry impaired aortic smooth muscle cells contractility in aortic medial degeneration. Biosci Rep. 2019;39: pubmed publisher
Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, et al. Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells. Inflammation. 2019;42:64-80 pubmed publisher
Liu X, Wang J, Gao L, Jiao Y, Liu C. Maternal Protein Restriction Induces Alterations in Hepatic Unfolded Protein Response-Related Molecules in Adult Rat Offspring. Front Endocrinol (Lausanne). 2018;9:676 pubmed publisher
Zhu J, Wang R, Xu T, Zhang S, Zhao Y, Li Z, et al. Salvianolic Acid A Attenuates Endoplasmic Reticulum Stress and Protects Against Cholestasis-Induced Liver Fibrosis via the SIRT1/HSF1 Pathway. Front Pharmacol. 2018;9:1277 pubmed publisher
Deng L, Gao X, Liu B, He X, Xu J, Qiang J, et al. NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway. Cell Death Dis. 2018;9:1143 pubmed publisher
Morimoto M, Waller Evans H, Ammous Z, Song X, Strauss K, Pehlivan D, et al. Bi-allelic CCDC47 Variants Cause a Disorder Characterized by Woolly Hair, Liver Dysfunction, Dysmorphic Features, and Global Developmental Delay. Am J Hum Genet. 2018;103:794-807 pubmed publisher
Wang D, Lao L, Pang X, Qiao Q, Pang L, Feng Z, et al. Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism. Int Immunopharmacol. 2018;65:256-267 pubmed publisher
Niu X, Zhang J, Ni J, Wang R, Zhang W, Sun S, et al. Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction. Biosci Rep. 2018;38: pubmed publisher
Ingles J, Simpson A, Kyathanahalli C, Anamthathmakula P, Hassan S, Jeyasuria P, et al. Preconditioning the uterine unfolded protein response maintains non-apoptotic Caspase 3-dependent quiescence during pregnancy. Cell Death Dis. 2018;9:933 pubmed publisher
Tsai T, Lai K, Su J, Wu Y, Sheu J. 7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway. Mar Drugs. 2018;16: pubmed publisher
Niu X, Zhang J, Ling C, Bai M, Peng Y, Sun S, et al. Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway. J Int Med Res. 2018;46:1717-1733 pubmed publisher
Sun W, Yang J, Zhang Y, Xi Y, Wen X, Yuan D, et al. Exogenous H2S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes. Cell Biosci. 2017;7:67 pubmed publisher
Liu Z, Wang Y, Wang Y, Dong W, Xia X, Song E, et al. Effect of Subcellular Translocation of Protein Disulfide Isomerase on Tetrachlorobenzoquinone-Induced Signaling Shift from Endoplasmic Reticulum Stress to Apoptosis. Chem Res Toxicol. 2017;30:1804-1814 pubmed publisher
Liu Y, Jiang Z, Zhou Y, Qiu H, Wang G, Luo Y, et al. β-elemene regulates endoplasmic reticulum stress to induce the apoptosis of NSCLC cells through PERK/IRE1α/ATF6 pathway. Biomed Pharmacother. 2017;93:490-497 pubmed publisher
Han K, Hassanzadeh S, Singh K, Menazza S, Nguyen T, Stevens M, et al. Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress. Sci Rep. 2017;7:2093 pubmed publisher
Sheng L, Cai L, Liu J, Zhang S, Xu J, Zhang X, et al. Imaging specific newly synthesized proteins within cells by fluorescence resonance energy transfer. Chem Sci. 2017;8:748-754 pubmed publisher
Li Y, Lu G, Sun D, Zuo H, Wang D, Yan J. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS ONE. 2017;12:e0174821 pubmed publisher
Zhou F, Zhang W, Zhou J, Li M, Zhong F, Zhang Y, et al. Involvement of endoplasmic reticulum stress in formalin-induced pain is attenuated by 4-phenylbutyric acid. J Pain Res. 2017;10:653-662 pubmed publisher
La X, Zhang L, Li Z, Yang P, Wang Y. Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells. Oncotarget. 2017;8:20909-20924 pubmed publisher
Wang Y, Wu H, Li Z, Yang P, Li Z. A positive feedback loop between GRP78 and VPS34 is critical for GRP78-mediated autophagy in cancer cells. Exp Cell Res. 2017;351:24-35 pubmed publisher
Yang F, Yu X, Li T, Wu J, Zhao Y, Liu J, et al. Exogenous H2S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes. Am J Physiol Endocrinol Metab. 2017;312:E190-E203 pubmed publisher
Jin J, Blackwood E, Azizi K, Thuerauf D, Fahem A, Hofmann C, et al. ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart. Circ Res. 2017;120:862-875 pubmed publisher
Lin J, Wang R, Chen J, Chiu C, Liao M, Wu Y. Cytotoxicity of 11-epi-Sinulariolide Acetate Isolated from Cultured Soft Corals on HA22T Cells through the Endoplasmic Reticulum Stress Pathway and Mitochondrial Dysfunction. Int J Mol Sci. 2016;17: pubmed
Liu J, Xiao M, Li J, Wang D, He Y, He J, et al. Activation of UPR Signaling Pathway is Associated With the Malignant Progression and Poor Prognosis in Prostate Cancer. Prostate. 2017;77:274-281 pubmed publisher
Chen Y, Liu Y, Lin S, Yang S, Que H, Liu S. Identification of Novel SCIRR69-Interacting Proteins During ER Stress Using SILAC-Immunoprecipitation Quantitative Proteomics Approach. Neuromolecular Med. 2017;19:81-93 pubmed publisher
Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu K, et al. Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs. Biomed Pharmacother. 2016;80:63-72 pubmed publisher
Zhou Y, Zhang S, Dai C, Tang S, Yang X, Li D, et al. Quinocetone triggered ER stress-induced autophagy via ATF6/DAPK1-modulated mAtg9a trafficking. Cell Biol Toxicol. 2016;32:141-52 pubmed publisher
Xu D, Su C, Song X, Shi Q, Fu J, Hu L, et al. Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release. Chem Res Toxicol. 2015;28:1326-37 pubmed publisher
Yu H, Zheng L, Xu L, Yin L, Lin Y, Li H, et al. Potent effects of the total saponins from Dioscorea nipponica Makino against streptozotocin-induced type 2 diabetes mellitus in rats. Phytother Res. 2015;29:228-40 pubmed publisher
product information
CatalogNo :
24169-1-AP
AntigenName :
ATF6
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
activating transcription factor 6
Immunogen :
Fusion Protein
Species :
human, monkey, mouse, pig, rat, swine
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
ATF6, ATF6 alpha, ATF6A
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC014969
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Membrane Proteins;Metabolism;Signal transduction;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:25 ; IHC 1:50 ; IP 1:1500 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.