This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
PHLPP
catalog :
22789-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 11
Reference
Zhang M, Wang X, Liu M, Liu D, Pan J, Tian J, et al. Inhibition of PHLPP1 ameliorates cardiac dysfunction via activation of the PI3K/Akt/mTOR signalling pathway in diabetic cardiomyopathy. J Cell Mol Med. 2020;24:4612-4623 pubmed publisher
Goldbraikh D, Neufeld D, Eid Mutlak Y, Lasry I, Gilda J, Parnis A, et al. USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation. EMBO Rep. 2020;21:e48791 pubmed publisher
Song Y, Li P, Qin L, Xu Z, Jiang B, Ma C, et al. CUL4B negatively regulates Toll-like receptor-triggered proinflammatory responses by repressing Pten transcription. Cell Mol Immunol. 2019;: pubmed publisher
Zhang C, Smith M, Zhou G, Lai A, Hoy R, Mroz V, et al. Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice. Cell Death Dis. 2019;10:754 pubmed publisher
Cohen Katsenelson K, Stender J, Kawashima A, Lordén G, Uchiyama S, Nizet V, et al. PHLPP1 counter-regulates STAT1-mediated inflammatory signaling. elife. 2019;8: pubmed publisher
Baffi T, Van A, Zhao W, Mills G, Newton A. Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer. Mol Cell. 2019;74:378-392.e5 pubmed publisher
Xie Y, Lv D, Wang W, YE M, Chen X, Yang H. High PHLPP1 expression levels predicts longer time of acquired resistance to EGFR tyrosine kinase inhibitors in patients with lung adenocarcinoma. Oncotarget. 2017;8:59000-59007 pubmed publisher
Xiong X, Wen Y, Mitov M, C Oaks M, Miyamoto S, Gao T. PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells. Cell Death Discov. 2017;3:16103 pubmed publisher
Xiong X, Li X, Wen Y, Gao T. Pleckstrin Homology (PH) Domain Leucine-rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C. J Biol Chem. 2016;291:25167-25178 pubmed
Smith A, Wen Y, Stevens P, Liu J, Wang C, Gao T. PHLPP negatively regulates cell motility through inhibition of Akt activity and integrin expression in pancreatic cancer cells. Oncotarget. 2016;7:7801-15 pubmed publisher
Wen Y, Li X, Goretsky T, Weiss H, Barrett T, Gao T. Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis. Biochim Biophys Acta. 2015;1852:2013-23 pubmed publisher
product information
CatalogNo :
22789-1-AP
AntigenName :
PHLPP
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
PH domain and leucine rich repeat protein phosphatase
Immunogen :
Fusion Protein
Species :
human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
hSCOP, KIAA0606, PHLPP, PHLPP1, PLEKHE1, SCOP
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC126277
Category :
Apoptosis;Binding Proteins;Cytoskeleton/Scaffold Proteins;Immunology;Membrane Proteins;Metabolism;Miscellaneous;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:50 ; IP 1:600 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.