This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
PTEN
catalog :
22034-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 54
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:2000; loading ...; fig 5f
Jiang Z, Tang Y, Song H, Yang M, Li B, Ni C. miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6. Int J Mol Med. 2020;45:45-52 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 5c
  • western blot; human; 1:1000; loading ...; fig 5b, 5d
Sun B, Zhao X, Ming J, Liu X, Liu D, Jiang C. Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma. Oncogene. 2019;38:6142-6157 pubmed publisher
  • western blot; human; 1:250; loading ...; fig 4b
Mizunuma M, Yokoyama Y, Futagami M, Horie K, Watanabe J, Mizunuma H. FOXP1 forkhead transcription factor is associated with the pathogenesis of endometrial cancer. Heliyon. 2016;2:e00116 pubmed publisher
Yu M, Liu W, Li J, Lu J, Lu H, Jia W, et al. Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway. Stem Cell Res Ther. 2020;11:350 pubmed publisher
Zhang Y, Guo J, Cai E, Cai J, Wen Y, Lu S, et al. HOTAIR maintains the stemness of ovarian cancer stem cells via the miR-206/TBX3 axis. Exp Cell Res. 2020;395:112218 pubmed publisher
Li Y, Zhang M, Li F. LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN. Histol Histopathol. 2020;:18245 pubmed publisher
Wang Z, Yu W, Qiang Y, Xu L, Ma F, Ding P, et al. LukS-PV Inhibits Hepatocellular Carcinoma Progression by Downregulating HDAC2 Expression. Mol Ther Oncolytics. 2020;17:547-561 pubmed publisher
Liao Q, Feng X, Li X, Chen G, Chen J, Yang B, et al. Lapatinib‑induced inhibition of ovarian function is counteracted by the STAT3 pathway both in vivo and in vitro. Oncol Rep. 2020;44:1127-1135 pubmed publisher
Gao X, Zhu L, Lu X, Wang Y, Li R, Jiang G. KIF15 contributes to cell proliferation and migration in breast cancer. Hum Cell. 2020;: pubmed publisher
Zhang X, Pan J, Wang G, Li H, Wang J, Jiang X, et al. Effect of STAT3 mediated epigenetic regulation in pre-eclampsia: an analysis of trial data. Eur Rev Med Pharmacol Sci. 2020;24:5843-5855 pubmed publisher
Dai H, Li M, Yang W, Sun X, Wang P, Wang X, et al. Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling. Aging (Albany NY). 2020;12:11717-11731 pubmed publisher
Wang D, Zhu X, Tang X, Li H, Yizhen X, Chen D. Auxiliary antitumor effects of fungal proteins from Hericium erinaceus by target on the gut microbiota. J Food Sci. 2020;85:1872-1890 pubmed publisher
Tan Y, Yin L, Sun Z, Shao S, Chen W, Man X, et al. Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro. Int J Biol Macromol. 2020;153:349-356 pubmed publisher
Yan Z, Zang B, Gong X, Ren J, Wang R. MiR-214-3p exacerbates kidney damages and inflammation induced by hyperlipidemic pancreatitis complicated with acute renal injury. Life Sci. 2020;241:117118 pubmed publisher
Guo J, Fu W, Xiang M, Zhang Y, Zhou K, Xu C, et al. Notch1 Drives the Formation and Proliferation of Intrahepatic Cholangiocarcinoma. Curr Med Sci. 2019;39:929-937 pubmed publisher
Feng C, So H, Yin S, Su X, Xu Q, Wang S, et al. MicroRNA-532-3p Suppresses Malignant Behaviors of Tongue Squamous Cell Carcinoma via Regulating CCR7. Front Pharmacol. 2019;10:940 pubmed publisher
He T, Sun Y, Zhang Y, Zhao S, Zheng Y, Hao G, et al. MicroRNA-200b and microRNA-200c are up-regulated in PCOS granulosa cell and inhibit KGN cell proliferation via targeting PTEN. Reprod Biol Endocrinol. 2019;17:68 pubmed publisher
Liu S, Zhang S, Lv X, Lu J, Ren C, Zeng Z, et al. Limonin ameliorates ulcerative colitis by regulating STAT3/miR-214 signaling pathway. Int Immunopharmacol. 2019;75:105768 pubmed publisher
Zhang D, Ren L, Zhao M, Yang C, Liu X, Zhang H, et al. Role of Tim-3 in Decidual Macrophage Functional Polarization During Abnormal Pregnancy With Toxoplasma gondii Infection. Front Immunol. 2019;10:1550 pubmed publisher
Chen S, Li D, Zhang H, Yu D, Chen R, Zhang B, et al. The development of a cell-based model for the assessment of carcinogenic potential upon long-term PM2.5 exposure. Environ Int. 2019;131:104943 pubmed publisher
Guo J, Li Y, Duan H, Yuan L. LncRNA TUBA4B functions as a competitive endogenous RNA to inhibit gastric cancer progression by elevating PTEN via sponging miR-214 and miR-216a/b. Cancer Cell Int. 2019;19:156 pubmed publisher
Li J, Yang X, Liu F, Song Y, Liu Y. Evaluation of differentially expressed microRNAs in vitrified oocytes by next generation sequencing. Int J Biochem Cell Biol. 2019;: pubmed publisher
Jin G, Liu Y, Zhang J, Bian Z, Yao S, Fei B, et al. A panel of serum exosomal microRNAs as predictive markers for chemoresistance in advanced colorectal cancer. Cancer Chemother Pharmacol. 2019;: pubmed publisher
Ma Q, Gao Y, Xu P, Li K, Xu X, Gao J, et al. Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTEN/AKT Pathway via Promoting Ras Homolog Family Member B (RhoB). Biomed Res Int. 2019;2019:3235021 pubmed publisher
Dong C, Liu X, Wang H, Li J, Dai L, Li J, et al. Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin. Onco Targets Ther. 2019;12:1947-1956 pubmed publisher
Liu G, Zhou J, Dong M. Down-regulation of miR-543 expression increases the sensitivity of colorectal cancer cells to 5-Fluorouracil through the PTEN/PI3K/AKT pathway. Biosci Rep. 2019;39: pubmed publisher
Wu L, Yuan W, Chen J, Zhou Z, Shu Y, Ji J, et al. Increased miR-214 expression suppresses cell migration and proliferation in Hirschsprung disease by interacting with PLAGL2. Pediatr Res. 2019;: pubmed publisher
Cao Z, Ji J, Zhang C, Wang F, Xu H, Yu Y, et al. The preoperative neutrophil-to-lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving radical prostatectomy. Cancer Med. 2019;8:1004-1012 pubmed publisher
Shen X, Zhong J, Yu P, Zhao Q, Huang T. YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein. Biochem Biophys Res Commun. 2019;509:448-454 pubmed publisher
Xu Y, Zhang G, Zou C, Gong Z, Wang S, Liu J, et al. Long noncoding RNA DGCR5 suppresses gastric cancer progression by acting as a competing endogenous RNA of PTEN and BTG1. J Cell Physiol. 2019;234:11999-12010 pubmed publisher
Shen F, Xiong Z, Kong J, Wang L, Cheng Y, Jin J, et al. Triptolide impairs thioredoxin system by suppressing Notch1-mediated PTEN/Akt/Txnip signaling in hepatocytes. Toxicol Lett. 2019;300:105-115 pubmed publisher
Wang S, Huang Y, Yan Y, Zhou H, Wang M, Liao L, et al. Calpain2 but not calpain1 mediated by calpastatin following glutamate-induced regulated necrosis in rat retinal neurons. Ann Anat. 2019;221:57-67 pubmed publisher
Mu Z, Sun Q. Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway. Mol Med Rep. 2018;18:4603-4610 pubmed publisher
Nie X, Fan J, Li H, Yin Z, Zhao Y, Dai B, et al. miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN. Mol Ther Nucleic Acids. 2018;12:254-266 pubmed publisher
He Y, Khan M, Yang J, Yao M, Yu S, Gao H. Proscillaridin A induces apoptosis, inhibits STAT3 activation and augments doxorubicin toxicity in prostate cancer cells. Int J Med Sci. 2018;15:832-839 pubmed publisher
Zhao X, Yang S, Yan Y, Zhang X, Zhang L, Jiao B, et al. Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis. BMC Med Genomics. 2018;11:59 pubmed publisher
Zhu X, Li Z, Li T, Long F, Lv Y, Liu L, et al. Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma. Biomed Pharmacother. 2018;102:502-509 pubmed publisher
Maryam A, Mehmood T, Yan Q, Li Y, Khan M, Ma T. Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells. Oxid Med Cell Longev. 2018;2018:3853409 pubmed publisher
Gao Q, Tang L, Wu L, Li K, Wang H, Li W, et al. LASP1 promotes nasopharyngeal carcinoma progression through negatively regulation of the tumor suppressor PTEN. Cell Death Dis. 2018;9:393 pubmed publisher
Ran H, Zhu Y, Deng R, Zhang Q, Liu X, Feng M, et al. Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN. J Exp Clin Cancer Res. 2018;37:54 pubmed publisher
Liao B, Zhou H, Liang H, Li C. Regulation of ERK and AKT pathways by hepatitis B virus X protein via the Notch1 pathway in hepatocellular carcinoma. Int J Oncol. 2017;51:1449-1459 pubmed publisher
Zhao Q, Guan J, Zhang Z, Lv J, Wang Y, Liu L, et al. Inhibition of Rad51 sensitizes breast cancer cells with wild-type PTEN to olaparib. Biomed Pharmacother. 2017;94:165-168 pubmed publisher
Wang Y, Chen F, Yang Z, Zhao M, Zhang S, Gao Y, et al. The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2. Sci Rep. 2017;7:2070 pubmed publisher
Li N, Miao Y, Shan Y, Liu B, Li Y, Zhao L, et al. MiR-106b and miR-93 regulate cell progression by suppression of PTEN via PI3K/Akt pathway in breast cancer. Cell Death Dis. 2017;8:e2796 pubmed publisher
Lu J, Xie L, Liu C, Zhang Q, Sun S. PTEN/PI3k/AKT Regulates Macrophage Polarization in Emphysematous mice. Scand J Immunol. 2017;85:395-405 pubmed publisher
Miao Y, Zheng W, Li N, Su Z, Zhao L, Zhou H, et al. MicroRNA-130b targets PTEN to mediate drug resistance and proliferation of breast cancer cells via the PI3K/Akt signaling pathway. Sci Rep. 2017;7:41942 pubmed publisher
Xu J, Liu D, Niu H, Zhu G, Xu Y, Ye D, et al. Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer. J Exp Clin Cancer Res. 2017;36:19 pubmed publisher
Zhang C, Li C, Chen S, Li Z, Ma L, Jia X, et al. Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Sci Rep. 2017;7:41082 pubmed publisher
Chen L, Zhang F, Sheng X, Zhang S, Chen Y, Liu B. MicroRNA-106a regulates phosphatase and tensin homologue expression and promotes the proliferation and invasion of ovarian cancer cells. Oncol Rep. 2016;36:2135-41 pubmed publisher
Yuan S, Wen J, Cheng J, Shen W, Zhou S, Yan W, et al. Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway. Cell Cycle. 2016;15:2895-2905 pubmed
Niu X, Fu N, Du J, Wang R, Wang Y, Zhao S, et al. miR-1273g-3p modulates activation and apoptosis of hepatic stellate cells by directly targeting PTEN in HCV-related liver fibrosis. FEBS Lett. 2016;590:2709-24 pubmed publisher
Huang C, Lei K, Tsang N. Paper-based microreactor array for rapid screening of cell signaling cascades. Lab Chip. 2016;16:2911-20 pubmed publisher
Huang W, Tian S, Hang P, Sun C, Guo J, Du Z. Combination of microRNA-21 and microRNA-146a Attenuates Cardiac Dysfunction and Apoptosis During Acute Myocardial Infarction in Mice. Mol Ther Nucleic Acids. 2016;5:e296 pubmed publisher
Eritja N, Santacana M, Maiques O, González Tallada X, Dolcet X, Matias Guiu X. Modeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: endometrial cancer as a model. Methods. 2015;77-78:31-40 pubmed publisher
product information
CatalogNo :
22034-1-AP
AntigenName :
PTEN
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
phosphatase and tensin homolog
Immunogen :
Fusion Protein
Species :
human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
10q23del, Bannayan Zonana syndrome, BC005821, BZS, ITGA 2, MGC11227, MHAM, MMAC1, Multiple hamartoma (Cowden syndrome), phosphatase and tensin homolog, PTEN, PTEN1, TEP1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC005821
Category :
Apoptosis;Cell Cycle;Cytoskeleton/Scaffold Proteins;Immunology;Metabolism;Neurology;Oncogene(s) and Tumor Suppressor(s);Signal transduction;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IHC 1:1000 ; IP 1:500 ; WB 1:5000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.