This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
NMDAR2B/GRIN2B
catalog :
21920-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 28
Reference
Gruszczynska Biegala J, Strucinska K, Maciąg F, Majewski L, Sladowska M, Kuznicki J. STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons. Cells. 2020;9: pubmed publisher
Wang J, Fei Z, Liang J, Zhou X, Qin G, Zhang D, et al. EphrinB/EphB Signaling Contributes to the Synaptic Plasticity of Chronic Migraine Through NR2B Phosphorylation. Neuroscience. 2020;428:178-191 pubmed publisher
Xian H, Jiang Y, Zhang H, Ma S, Zhao R, Cong R. CCL2-CCR2 Axis Potentiates NMDA Receptor Signaling to Aggravate Neuropathic Pain Induced by Brachial Plexus Avulsion. Neuroscience. 2020;425:29-38 pubmed publisher
He Q, Deng H, Xu L, Zhu J, Ni H, Wang T, et al. SAP102 contributes to hyperalgesia formation in the cancer induced bone pain rat model by anchoring NMDA receptors. Neurosci Lett. 2020;714:134595 pubmed publisher
Qi F, Liu T, Zhang X, Gao X, Li Z, Chen L, et al. Ketamine reduces remifentanil-induced postoperative hyperalgesia mediated by CaMKII-NMDAR in the primary somatosensory cerebral cortex region in mice. Neuropharmacology. 2020;162:107783 pubmed publisher
Zhang H, Tian X, Lu X, Xu D, Guo Y, Dong Z, et al. TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation. J Clin Invest. 2019;129:3864-3876 pubmed publisher
Lu X, Zhang Q, Wang T. The second PDZ domain of scaffold protein Frmpd2 binds to GluN2A of NMDA receptors. Biochem Biophys Res Commun. 2019;: pubmed publisher
Wang X, Luo C, Mao X, Li X, Yin J, Zhang W, et al. Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats. Brain Res. 2019;: pubmed publisher
Kool M, Onori M, Borgesius N, van de Bree J, Elgersma Hooisma M, Nio E, et al. CAMK2-dependent signaling in neurons is essential for survival. J Neurosci. 2019;: pubmed publisher
Chen K, Sun D, Qu S, Chen Y, Wang J, Zhou L, et al. Prenatal cold exposure causes hypertension in offspring by hyperactivity of the sympathetic nervous system. Clin Sci (Lond). 2019;133:1097-1113 pubmed publisher
Wen Y, Wu K, Xie Y, Dan W, Zhan Y, Shi Q. Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy. Biochem Biophys Res Commun. 2019;511:79-86 pubmed publisher
Xu X, Jiang S, Xu E, Wu X, Zhao R. Inhibition of CB1 receptor ameliorates spatial learning and memory impairment in mice with traumatic brain injury. Neurosci Lett. 2019;696:127-131 pubmed publisher
So L, Munger S, Miller J. Social context-dependent singing alters molecular markers of dopaminergic and glutamatergic signaling in finch basal ganglia Area X. Behav Brain Res. 2019;360:103-112 pubmed publisher
Bai D, Li Q, Wang J, Zhao J, Deng X, Yuan L, et al. Neurotoxicity, behavioral changes and gene-expression profile of mice exposed to SnS2 nanoflowers. Toxicol Res (Camb). 2018;7:1267-1279 pubmed publisher
Wang X, Zhou H, Wang S, Liu C, Qin G, Fu Q, et al. NR2B-Tyr phosphorylation regulates synaptic plasticity in central sensitization in a chronic migraine rat model. J Headache Pain. 2018;19:102 pubmed publisher
Liu X, Zhang L, Jin L, Tan Y, Li W, Tang J. HCN2 contributes to oxaliplatin-induced neuropathic pain through activation of the CaMKII/CREB cascade in spinal neurons. Mol Pain. 2018;14:1744806918778490 pubmed publisher
Huang L, Guo S, Thitiseranee L, Yang Y, Zhou Y, Yao Y. N-methyl D-aspartate receptor subtype 2B antagonist, Ro 25-6981, attenuates neuropathic pain by inhibiting postsynaptic density 95 expression. Sci Rep. 2018;8:7848 pubmed publisher
Cao M, Fang J, Wang X, Wang Y, Duan K, Ye F, et al. Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats. Brain Res. 2018;1684:21-29 pubmed publisher
Zhao L, Zhang Y, Yang F, Zhu D, Li N, Zhao L, et al. Effects of intrathecal bupivacaine on the NR2B/CaMKII?/CREB signaling pathway in the rat lumbar spinal cord. Mol Med Rep. 2018;17:4508-4514 pubmed publisher
Li Y, Wang L, Zhang X, Huang M, Li S, Wang X, et al. Inhibition of Cdk5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex. Neuropharmacology. 2018;128:207-220 pubmed publisher
Zhang S, Wang X, Ai S, Ouyang W, Le Y, Tong J. Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice. PLoS ONE. 2017;12:e0188273 pubmed publisher
Hui S, Yang Y, Peng W, Sheng C, Gong W, Chen S, et al. Protective effects of Bushen Tiansui decoction on hippocampal synapses in a rat model of Alzheimer's disease. Neural Regen Res. 2017;12:1680-1686 pubmed publisher
Tang Y, Wang X, Zhang S, Duan S, Qing W, Chen G, et al. Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age. PLoS ONE. 2017;12:e0182471 pubmed publisher
Wen Y, Fu P, Wu K, Si K, Xie Y, Dan W, et al. Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction. Neurochem Res. 2017;42:2154-2166 pubmed publisher
Tang L, Zhang Y, Chen G, Xiong Y, Wang X, Zhu B. Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model. Neurochem Res. 2017;42:1211-1218 pubmed publisher
Zhang Y, Chen G, Gao B, Li Y, Liang S, Wang X, et al. NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B. Sci Rep. 2016;6:37713 pubmed publisher
Ahmed M, Dong Y, Lu Y, Tucker D, Wang R, Zhang Q. Beneficial Effects of a CaMKII? Inhibitor TatCN21 Peptide in Global Cerebral Ischemia. J Mol Neurosci. 2017;61:42-51 pubmed publisher
Zhang X, Shen F, Xu D, Zhao X. A lasting effect of postnatal sevoflurane anesthesia on the composition of NMDA receptor subunits in rat prefrontal cortex. Int J Dev Neurosci. 2016;54:62-69 pubmed publisher
product information
CatalogNo :
21920-1-AP
AntigenName :
NMDAR2B/GRIN2B
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Immunogen :
Fusion Protein
Species :
human, mouse, rat, zebra finches
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, FC, CoIP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
GluN2B, GRIN2B, hNR3, NMDAR2B, NR2B, NR3
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC113620
Category :
Binding Proteins;Membrane Proteins;Neurology;Signal transduction;Transport/Trafficking;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
AppTiter :
FC 1:0 ; IF 1:25 ; IHC 1:50 ; IP 1:2000 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.