This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
IFIH1/MDA5
catalog :
21775-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunoprecipitation, RNA immunoprecipitation
citations: 14
Reference
Guallar D, Fuentes Iglesias A, Souto Y, Ameneiro C, Freire Agulleiro O, Pardavila J, et al. ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress. Cell Stem Cell. 2020;: pubmed publisher
Scoles D, Dansithong W, Pflieger L, Paul S, Gandelman M, Figueroa K, et al. ALS-associated genes in SCA2 mouse spinal cord transcriptomes. Hum Mol Genet. 2020;29:1658-1672 pubmed publisher
Lee A, Pan D, Bao X, Hu M, Li F, Li C. Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy. Radiat Res. 2020;193:305-317 pubmed publisher
Bianco C, Mohr I. Ribosome biogenesis restricts innate immune responses to virus infection and DNA. elife. 2019;8: pubmed publisher
Rubio R, Depledge D, Bianco C, Thompson L, Mohr I. RNA m6 A modification enzymes shape innate responses to DNA by regulating interferon β. Genes Dev. 2018;32:1472-1484 pubmed publisher
Akiyama H, Miller C, Ettinger C, Belkina A, Snyder Cappione J, Gummuluru S. HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction. Nat Commun. 2018;9:3450 pubmed publisher
Burgess H, Mohr I. Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS. J Virol. 2018;92: pubmed publisher
Zhou P, Ding X, Wan X, Liu L, Yuan X, Zhang W, et al. MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation. Nat Commun. 2018;9:1243 pubmed publisher
Shang J, Xia T, Han Q, Zhao X, Hu M, Shu H, et al. Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity. Proteomics. 2018;18: pubmed publisher
Meng J, Yao Z, He Y, Zhang R, Zhang Y, Yao X, et al. ARRDC4 regulates enterovirus 71-induced innate immune response by promoting K63 polyubiquitination of MDA5 through TRIM65. Cell Death Dis. 2017;8:e2866 pubmed publisher
Lang X, Tang T, Jin T, Ding C, Zhou R, Jiang W. TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity. J Exp Med. 2017;214:459-473 pubmed publisher
Zhang L, Xin Q, Zhu S, Wan W, Wang W, Xiao G. Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus. J Virol. 2016;90:10259-10270 pubmed publisher
Wang Y, Liu L. The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern To Promote Beta Interferon Induction via a Toll-Like-Receptor-Related TRAF3-Independent Mechanism. MBio. 2016;7:e01872-15 pubmed publisher
Zhang W, Zhang L, Zan Y, Du N, Yang Y, Tien P. Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins. J Gen Virol. 2015;96:170-82 pubmed publisher
product information
CatalogNo :
21775-1-AP
AntigenName :
IFIH1/MDA5
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
interferon induced with helicase C domain 1
Immunogen :
Fusion Protein
Species :
human, mouse
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, RIP, IP, IHC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
Helicard, Helicase with 2 CARD domains, Hlcd, IDDM19, IFIH1, MDA 5, MDA5, RH116, RLR-2
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC111750
Category :
Apoptosis;Binding Proteins;Cytoskeleton/Scaffold Proteins;Immunology;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IHC 1:200 ; IP 1:300 ; WB 1:1500 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.