This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
Cathepsin D
catalog :
21327-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
citations: 20
Reference
Zhou K, Zheng Z, Li Y, Han W, Zhang J, Mao Y, et al. TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress. Theranostics. 2020;10:9280-9302 pubmed publisher
Chen M, Ding Y, Ke Y, Zeng Y, Liu N, Zhong Y, et al. Anti-tumour activity of zinc ionophore pyrithione in human ovarian cancer cells through inhibition of proliferation and migration and promotion of lysosome-mitochondrial apoptosis. Artif Cells Nanomed Biotechnol. 2020;48:824-833 pubmed publisher
Hossain M, Marcus J, Lee J, Garcia P, Singh V, Shacka J, et al. Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective. Autophagy. 2020;:1-19 pubmed publisher
Geng N, Wang X, Yu X, Wang R, Zhu Y, Zhang M, et al. Staphylococcus aureus Avoids Autophagy Clearance of Bovine Mammary Epithelial Cells by Impairing Lysosomal Function. Front Immunol. 2020;11:746 pubmed publisher
Cui X, Feng R, Wang J, Du C, Pi X, Chen D, et al. Heat shock factor 4 regulates lysosome activity by modulating the αB-crystallin-ATP6V1A-mTOR complex in ocular lens. Biochim Biophys Acta Gen Subj. 2020;1864:129496 pubmed publisher
Zhou K, Chen H, Lin J, Xu H, Wu H, Bao G, et al. FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival. Cell Death Dis. 2019;10:872 pubmed publisher
Li J, Bao G, ALyafeai E, Ding J, Li S, Sheng S, et al. Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy. Front Pharmacol. 2019;10:1017 pubmed publisher
Wei Y, Zhou J, Wu J, Huang J. ERβ promotes Aβ degradation via the modulation of autophagy. Cell Death Dis. 2019;10:565 pubmed publisher
Sheng J, Shen L, Sun L, Zhang X, Cui R, Wang L. Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk. Cell Prolif. 2019;52:e12609 pubmed publisher
Chen S, Zhou C, Yu H, Tao L, An Y, Zhang X, et al. 27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells. Front Mol Neurosci. 2019;12:14 pubmed publisher
Lin J, Lin R, Li S, Wu H, Ding J, Xiang G, et al. Protective effects of resveratrol on random-pattern skin flap survival: an experimental study. Am J Transl Res. 2019;11:379-392 pubmed
Lin J, Lin R, Li S, Wu H, Ding J, Xiang G, et al. Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy. Front Pharmacol. 2018;9:1178 pubmed publisher
Wang H, Li W, Xu J, Zhang T, Zuo D, Zhou Z, et al. NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy. Cell Death Dis. 2017;8:e3048 pubmed publisher
Yan X, Li Y, Yu H, Wang W, Wu C, Yang Y, et al. Epigallocatechin-3-gallate inhibits H2O2-induced apoptosis in Mouse Vascular Smooth Muscle Cells via 67kD Laminin Receptor. Sci Rep. 2017;7:7774 pubmed publisher
Xie X, Yi W, Zhang P, Wu N, Yan Q, Yang H, et al. Green Tea Polyphenols, Mimicking the Effects of Dietary Restriction, Ameliorate High-Fat Diet-Induced Kidney Injury via Regulating Autophagy Flux. Nutrients. 2017;9: pubmed publisher
Jinn S, Drolet R, Cramer P, Wong A, Toolan D, Gretzula C, et al. TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation. Proc Natl Acad Sci U S A. 2017;114:2389-2394 pubmed publisher
Wang Y, Liu Y, Liu X, Jiang L, Yang G, Sun X, et al. Citreoviridin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis in Human Liver HepG2 Cells. Toxins (Basel). 2015;7:3030-44 pubmed publisher
Wang H, Liu T, Li L, Wang Q, Yu C, Liu X, et al. Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species. Cell Biosci. 2015;5:4 pubmed publisher
Liu T, Men Q, Wu G, Yu C, Huang Z, Liu X, et al. Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells. Oncotarget. 2015;6:7992-8006 pubmed
Mei L, Chen Y, Wang Z, Wang J, Wan J, Yu C, et al. Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21. Br J Pharmacol. 2015;172:2232-45 pubmed publisher
product information
CatalogNo :
21327-1-AP
AntigenName :
Cathepsin D
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
cathepsin D
Immunogen :
Fusion Protein
Species :
bovine, human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
cathepsin D, CLN10, CPSD, CTSD
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC016320
Category :
Cytoskeleton/Scaffold Proteins;Membrane Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:25 ; IHC 1:200 ; WB 1:1500 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.