This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
PLOD2-Specific
catalog :
21214-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 19
Published Application/Species/Sample/DilutionReference
  • western blot; human
Cabral W, Ishikawa M, Garten M, Makareeva E, Sargent B, Weis M, et al. Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta. PLoS Genet. 2016;12:e1006156 pubmed publisher
Cai R, Wang P, Zhao X, Lu X, Deng R, Wang X, et al. LTBP1 promotes esophageal squamous cell carcinoma progression through epithelial-mesenchymal transition and cancer-associated fibroblasts transformation. J Transl Med. 2020;18:139 pubmed publisher
Du W, Liu N, Zhang Y, Liu X, Yang Y, Chen W, et al. PLOD2 promotes aerobic glycolysis and cell progression in colorectal cancer by upregulating HK2. Biochem Cell Biol. 2019;: pubmed publisher
Terajima M, Taga Y, Sricholpech M, Kayashima Y, Sumida N, Maeda N, et al. Role of Glycosyltransferase 25 Domain 1 in Type I Collagen Glycosylation and Molecular Phenotypes. Biochemistry. 2019;: pubmed publisher
Terajima M, Taga Y, Cabral W, Liu Y, Nagasawa M, Sumida N, et al. Cyclophilin B control of lysine post-translational modifications of skin type I collagen. PLoS Genet. 2019;15:e1008196 pubmed publisher
Kasamatsu A, Uzawa K, Hayashi F, Kita A, Okubo Y, Saito T, et al. Deficiency of lysyl hydroxylase 2 in mice causes systemic endoplasmic reticulum stress leading to early embryonic lethality. Biochem Biophys Res Commun. 2019;512:486-491 pubmed publisher
Saito T, Uzawa K, Terajima M, Shiiba M, Amelio A, Tanzawa H, et al. Aberrant Collagen Cross-linking in Human Oral Squamous Cell Carcinoma. J Dent Res. 2019;98:517-525 pubmed publisher
Lewis D, Pruitt H, Jain N, Ciccaglione M, McCaffery J, Xia Z, et al. A Feedback Loop between Hypoxia and Matrix Stress Relaxation Increases Oxygen-Axis Migration and Metastasis in Sarcoma. Cancer Res. 2019;79:1981-1995 pubmed publisher
Xu F, Zhang J, Hu G, Liu L, Liang W. Hypoxia and TGF-?1 induced PLOD2 expression improve the migration and invasion of cervical cancer cells by promoting epithelial-to-mesenchymal transition (EMT) and focal adhesion formation. Cancer Cell Int. 2017;17:54 pubmed publisher
Xu Y, Zhang L, Wei Y, Zhang X, Xu R, Han M, et al. Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes hypoxia-induced glioma migration and invasion. Oncotarget. 2017;8:23401-23413 pubmed publisher
Song Y, Zheng S, Wang J, Long H, Fang L, Wang G, et al. Hypoxia-induced PLOD2 promotes proliferation, migration and invasion via PI3K/Akt signaling in glioma. Oncotarget. 2017;8:41947-41962 pubmed publisher
Chen Y, Terajima M, Banerjee P, Guo H, Liu X, Yu J, et al. FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch. Sci Rep. 2017;7:46021 pubmed publisher
Guo H, Cho E, Devkota A, Chen Y, Russell W, Phillips G, et al. A scalable lysyl hydroxylase 2 expression system and luciferase-based enzymatic activity assay. Arch Biochem Biophys. 2017;618:45-51 pubmed publisher
Stratmann B, Engelbrecht B, Espelage B, Klusmeier N, Tiemann J, Gawlowski T, et al. Glyoxalase 1-knockdown in human aortic endothelial cells - effect on the proteome and endothelial function estimates. Sci Rep. 2016;6:37737 pubmed publisher
Gistelinck C, Witten P, Huysseune A, Symoens S, Malfait F, Larionova D, et al. Loss of Type I Collagen Telopeptide Lysyl Hydroxylation Causes Musculoskeletal Abnormalities in a Zebrafish Model of Bruck Syndrome. J Bone Miner Res. 2016;31:1930-1942 pubmed publisher
Lewis D, Park K, Tang V, Xu Y, Pak K, Eisinger Mathason T, et al. Intratumoral oxygen gradients mediate sarcoma cell invasion. Proc Natl Acad Sci U S A. 2016;113:9292-7 pubmed publisher
Miyamoto K, Seki N, Matsushita R, Yonemori M, Yoshino H, Nakagawa M, et al. Tumour-suppressive miRNA-26a-5p and miR-26b-5p inhibit cell aggressiveness by regulating PLOD2 in bladder cancer. Br J Cancer. 2016;115:354-63 pubmed publisher
Kurozumi A, Kato M, Goto Y, Matsushita R, Nishikawa R, Okato A, et al. Regulation of the collagen cross-linking enzymes LOXL2 and PLOD2 by tumor-suppressive microRNA-26a/b in renal cell carcinoma. Int J Oncol. 2016;48:1837-46 pubmed publisher
Chen Y, Terajima M, Yang Y, Sun L, Ahn Y, Panková D, et al. Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest. 2015;125:1147-62 pubmed publisher
product information
CatalogNo :
21214-1-AP
AntigenName :
PLOD2-Specific
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
Immunogen :
Fusion Protein
Species :
human, mouse, rat, zebrafish
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, FC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
LH2, Lysyl hydroxylase 2, PLOD2-Specific, TLH
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC037169
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Membrane Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
FC 1:0 ; IF 1:25 ; IHC 1:200 ; IP 1:500 ; WB 1:500 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.