| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; loading ...; fig 7b
| Zeng Z, Xu F, Zheng H, Cheng P, Chen Q, Ye Z, et al. LncRNA-MTA2TR functions as a promoter in pancreatic cancer via driving deacetylation-dependent accumulation of HIF-1α. Theranostics. 2019;9:5298-5314 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 4e
- western blot; human; 1:1000; loading ...; fig 4a
| Feng J, Wu L, Ji J, Chen K, Yu Q, Zhang J, et al. PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma. J Exp Clin Cancer Res. 2019;38:204 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Xiang J, Hu Q, Qin Y, Ji S, Xu W, Liu W, et al. TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer. Cell Death Dis. 2018;9:321 pubmed publisher |
- western blot; rat; 1:800; fig 4
| Li X, Chen Y, Wang L, Shang G, Zhang C, Zhao Z, et al. Quercetin alleviates pulmonary angiogenesis in a rat model of hepatopulmonary syndrome. Braz J Med Biol Res. 2016;49: pubmed publisher |
| Kim M, Shin J, Kim J, Son K, Kim Y, Jung C, et al. Anti-tumor efficacy of CKD-516 in combination with radiation in xenograft mouse model of lung squamous cell carcinoma. BMC Cancer. 2020;20:1057 pubmed publisher |
| Wang Y, Yang B, Lai Q, Shi J, Peng J, Zhang Y, et al. Reprogramming of m6A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia. RNA Biol. 2020;:1-13 pubmed publisher |
| Wang X, Lin Y, Zheng Y. Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration. Mol Med Rep. 2020;22:2318-2328 pubmed publisher |
| Zhong L, Wang R, Wang Y, Peng S, Ma Y, Ding S, et al. Dual inhibition of VEGF and PARP suppresses KRAS-mutant colorectal cancer. Neoplasia. 2020;22:365-375 pubmed publisher |
| Yan X, Yang C, Hu W, Chen T, Wang Q, Pan F, et al. Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway. Oncol Rep. 2020;44:103-114 pubmed publisher |
| Ndibalema A, Kabuye D, Wen S, Li L, Li X, Fan Q. Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha. Diabetes Metab Syndr Obes. 2020;13:1953-1967 pubmed publisher |
| Wang S, Zhong X, Wang C, Luo H, Lin L, Sun H, et al. USP22 positively modulates ERα action via its deubiquitinase activity in breast cancer. Cell Death Differ. 2020;: pubmed publisher |
| Dong D, Dong Y, Fu J, Lu S, Yuan C, Xia M, et al. Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells. Life Sci. 2020;255:117846 pubmed publisher |
| Han X, Ma W, Zhu Y, Sun X, Liu N. Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1α/PDK4 pathway. Mol Cell Endocrinol. 2020;514:110878 pubmed publisher |
| Gao F, Zuo B, Wang Y, Li S, Yang J, Sun D. Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway. Life Sci. 2020;255:117719 pubmed publisher |
| Hua Q, Mi B, Xu F, Wen J, Zhao L, Liu J, et al. Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis. Theranostics. 2020;10:4762-4778 pubmed publisher |
| Lin H, Zhou W, Huang Y, Ren M, Xu F, Wang H. Systemic hypoxia potentiates anti-tumor effects of metformin in hepatocellular carcinoma in mice. Acta Biochim Biophys Sin (Shanghai). 2020;52:421-429 pubmed publisher |
| Luo J, Luo X, Liu X, Fang Z, Xu J, Li L. DUSP9 Suppresses Proliferation and Migration of Clear Cell Renal Cell Carcinoma via the mTOR Pathway. Onco Targets Ther. 2020;13:1321-1330 pubmed publisher |
| Tang B, Tang M, Xu Q, Guo J, Xuan L, Zhou J, et al. MicroRNA-143-5p modulates pulmonary artery smooth muscle cells functions in hypoxic pulmonary hypertension through targeting HIF-1α. J Biosci. 2020;45: pubmed |
| Yin X, Xia J, Sun Y, Zhang Z. CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression. BMC Pulm Med. 2020;20:40 pubmed publisher |
| Cai Q, Wang X, Wang S, Jin L, Ding J, Zhou D, et al. Gallbladder Cancer Progression Is Reversed by Nanomaterial-Induced Photothermal Therapy in Combination with Chemotherapy and Autophagy Inhibition. Int J Nanomedicine. 2020;15:253-262 pubmed publisher |
| Feng J, Dai W, Mao Y, Wu L, Li J, Chen K, et al. Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis. J Exp Clin Cancer Res. 2020;39:24 pubmed publisher |
| Qin S, Yi M, Jiao D, Li A, Wu K. Distinct Roles of VEGFA and ANGPT2 in Lung Adenocarcinoma and Squamous Cell Carcinoma. J Cancer. 2020;11:153-167 pubmed publisher |
| Gao P, Wang L, Liu J, Dong F, Song W, Liao L, et al. Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway. Life Sci. 2020;242:117221 pubmed publisher |
| Xiao T, Sun J, Xing Z, Xie F, Yang L, Ding W. MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production. Cell Biol Int. 2020;44:821-829 pubmed publisher |
| Xu W, Zheng H, Yang R, Jiang L, Jiang S. HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway. Front Endocrinol (Lausanne). 2019;10:922 pubmed publisher |
| Zhang X, Ma N, Yao W, Li S, Ren Z. RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer. Cancer Cell Int. 2019;19:356 pubmed publisher |
| Pan C, Liu Q, Wu X. HIF1α/miR-520a-3p/AKT1/mTOR Feedback Promotes The Proliferation And Glycolysis Of Gastric Cancer Cells. Cancer Manag Res. 2019;11:10145-10156 pubmed publisher |
| Chai X, Le Y, Wang J, Mei C, Feng J, Zhao H, et al. Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1α Axis of Breast Cancer Cells. J Food Sci. 2019;84:3825-3832 pubmed publisher |
| Wang X, Lin L, Chai X, Wu Y, Li Y, Liu X. Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts. Int J Mol Med. 2019;: pubmed publisher |
| Xu W, Zheng H, Yang R, Liu T, Yu W, Zheng X, et al. Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy. Exp Mol Med. 2019;51:140 pubmed publisher |
| Sun C, Li X, Guo E, Li N, Zhou B, Lu H, et al. MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis. Oncogene. 2019;: pubmed publisher |
| Ohta S, Morine Y, Imura S, Ikemoto T, Arakawa Y, Iwahashi S, et al. Carbohydrate Antigen 19-9 Is a Prognostic Factor Which Correlates With HDAC1 and HIF-1α for Intrahepatic Cholangiocarcinoma. Anticancer Res. 2019;39:6025-6033 pubmed publisher |
| Zhu Y, Yu F, Tan Y, Hong Y, Meng T, Liu Y, et al. Reversing activity of cancer associated fibroblast for staged glycolipid micelles against internal breast tumor cells. Theranostics. 2019;9:6764-6779 pubmed publisher |
| Chu X, Xiang M, Feng L, Liu H, Zhou C. Prolyl hydroxylase 3 involvement in lung cancer progression under hypoxic conditions: association with hypoxia-inducible factor-1α and pyruvate kinase M2. J Thorac Dis. 2019;11:3941-3950 pubmed publisher |
| Tamada S, Mitsui T, Ohira A, Tani K, Maki J, Eguchi T, et al. Relationship between Intracellular Signaling of the (Pro)renin Receptor and the Pathogenesis of Preeclampsia. Acta Med Okayama. 2019;73:433-440 pubmed publisher |
| Lian G, Li X, Zhang L, Zhang Y, Sun L, Zhang X, et al. Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰. EBioMedicine. 2019;49:291-304 pubmed publisher |
| Bera R, Chiu M, Huang Y, Lin T, Kuo M, Shih L. RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia. J Hematol Oncol. 2019;12:104 pubmed publisher |
| Qian X, Li X, Shi Z, Bai X, Xia Y, Zheng Y, et al. KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis. Mol Cell. 2019;: pubmed publisher |
| Jiang M, Yin X, Qin B, Xuan S, Yuan X, Yin H, et al. Inhibiting Hypoxia and Chemotherapy-Induced Cancer Cell Metastasis under a Valid Therapeutic Effect by an Assistance of Biomimetic Oxygen Delivery. Mol Pharm. 2019;16:4530-4541 pubmed publisher |
| Li J, Yuan Y, Zhang L, Zhang H, Zhang S, Zhang Y, et al. Exogenous hydrogen sulfide protects against high glucose-induced apoptosis and oxidative stress by inhibiting the STAT3/HIF-1α pathway in H9c2 cardiomyocytes. Exp Ther Med. 2019;18:3948-3958 pubmed publisher |
| Zhang Y, Liu D, Hu H, Zhang P, Xie R, Cui W. HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury. Biomed Pharmacother. 2019;120:109464 pubmed publisher |
| Choong O, Chen C, Zhang J, Lin J, Lin P, Ruan S, et al. Hypoxia-induced H19/YB-1 cascade modulates cardiac remodeling after infarction. Theranostics. 2019;9:6550-6567 pubmed publisher |
| Huang R, Jin X, Gao Y, Yuan H, Wang F, Cao X. DZNep inhibits Hif-1α and Wnt signalling molecules to attenuate the proliferation and invasion of BGC-823 gastric cancer cells. Oncol Lett. 2019;18:4308-4316 pubmed publisher |
| Hu Y, Lou X, Wang R, Sun C, Liu X, Liu S, et al. Aspirin, a Potential GLUT1 Inhibitor in a Vascular Endothelial Cell Line. Open Med (Wars). 2019;14:552-560 pubmed publisher |
| Dai W, Wang Y, Yang T, Wang J, Wu W, Gu J. Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals. Cell Commun Signal. 2019;17:113 pubmed publisher |
| Chen L, Tian Q, Wang W. Association between CIRP expression and hypoxic-ischemic brain injury in neonatal rats. Exp Ther Med. 2019;18:1515-1520 pubmed publisher |
| Liu M, Zhong J, Zeng Z, Huang K, Ye Z, Deng S, et al. Hypoxia-induced feedback of HIF-1α and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein. Theranostics. 2019;9:4795-4810 pubmed publisher |
| Li Y, Xu Q, Yang W, Wu T, Lu X. Oleanolic acid reduces aerobic glycolysis-associated proliferation by inhibiting yes-associated protein in gastric cancer cells. Gene. 2019;712:143956 pubmed publisher |
| Nagai T, Imamura T, Ogawa T, Minagawa T, Domen T, Suzuki T, et al. Nicotine-induced hypoxia in rat urothelium deteriorates bladder storage functions. Neurourol Urodyn. 2019;38:1560-1570 pubmed publisher |
| Liu Y, Li Y, Huang Z, Wang Z, Nan L, Wang F, et al. The effect of intervertebral disc degenerative change on biological characteristics of nucleus pulposus mesenchymal stem cell: an in vitro study in rats. Connect Tissue Res. 2019;60:376-388 pubmed publisher |
| Kang L, Shen L, Lu L, Wang D, Zhao Y, Chen C, et al. Asparaginyl endopeptidase induces endothelial permeability and tumor metastasis via downregulating zonula occludens protein ZO-1. Biochim Biophys Acta Mol Basis Dis. 2019;: pubmed publisher |
| Li Y, Luo J, Lin M, Zhi P, Guo W, Han M, et al. Co-Delivery of Metformin Enhances the Antimultidrug Resistant Tumor Effect of Doxorubicin by Improving Hypoxic Tumor Microenvironment. Mol Pharm. 2019;: pubmed publisher |
| Liu D, Zhang Y, Hu H, Zhang P, Cui W. Downregulation of microRNA‑199a‑5p attenuates hypoxia/reoxygenation‑induced cytotoxicity in cardiomyocytes by targeting the HIF‑1α‑GSK3β‑mPTP axis. Mol Med Rep. 2019;19:5335-5344 pubmed publisher |
| Tian X, Wang C, Jin X, Li M, Wang F, Huang W, et al. Acidic Microenvironment Up-Regulates Exosomal miR-21 and miR-10b in Early-Stage Hepatocellular Carcinoma to Promote Cancer Cell Proliferation and Metastasis. Theranostics. 2019;9:1965-1979 pubmed publisher |
| Zhao Y, Yan J, Li A, Zhang Z, Li Z, Guo K, et al. Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats. Toxicol Lett. 2019;310:31-38 pubmed publisher |
| Li Z, Chen Y, An T, Liu P, Zhu J, Yang H, et al. Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway. J Exp Clin Cancer Res. 2019;38:139 pubmed publisher |
| Hu Q, Qin Y, Ji S, Xu W, Liu W, Sun Q, et al. UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer. Cancer Lett. 2019;452:226-236 pubmed publisher |
| Dong C, Liu X, Wang H, Li J, Dai L, Li J, et al. Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin. Onco Targets Ther. 2019;12:1947-1956 pubmed publisher |
| Chen Y, Liu P, Sun P, Jiang J, Zhu Y, Dong T, et al. Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme. Theranostics. 2019;9:1453-1473 pubmed publisher |
| Aiken C, Tarry Adkins J, Spiroski A, Nuzzo A, Ashmore T, Rolfo A, et al. Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats. J Physiol. 2019;597:2391-2401 pubmed publisher |
| Gao Y, Liu B, Feng L, Sun B, He S, Yang Y, et al. Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma. Front Oncol. 2019;9:33 pubmed publisher |
| Wang Y, Bai C, Ruan Y, Liu M, Chu Q, Qiu L, et al. Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia. Nat Commun. 2019;10:201 pubmed publisher |
| Li S, Zhao Y, Wang Z, Wang J, Liu C, Sun D. Transplantation of Amniotic Fluid-Derived Stem Cells Preconditioned with Glial Cell Line-Derived Neurotrophic Factor Gene Alleviates Renal Fibrosis. Cell Transplant. 2019;28:65-78 pubmed publisher |
| Feng J, Zhang Y, She X, Sun Y, Fan L, Ren X, et al. Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment. Oncogene. 2019;38:103-119 pubmed publisher |
| Jiang T, Zhou M, Fan J. Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro. Onco Targets Ther. 2018;11:7865-7872 pubmed publisher |
| Gu S, Hua H, Guo X, Jia Z, Zhang Y, Maslov L, et al. PGC-1α Participates in the Protective Effect of Chronic Intermittent Hypobaric Hypoxia on Cardiomyocytes. Cell Physiol Biochem. 2018;50:1891-1902 pubmed publisher |
| Yang H, Li Q, Wang C, Wang J, Lv J, Wang L, et al. Cytotoxic Necrotizing Factor 1 Downregulates CD36 Transcription in Macrophages to Induce Inflammation During Acute Urinary Tract Infections. Front Immunol. 2018;9:1987 pubmed publisher |
| Liu Q, Fan D, Adah D, Wu Z, Liu R, Yan Q, et al. CRISPR/Cas9‑mediated hypoxia inducible factor‑1α knockout enhances the antitumor effect of transarterial embolization in hepatocellular carcinoma. Oncol Rep. 2018;40:2547-2557 pubmed publisher |
| Xu Y, Wang X, Huang Y, Ma Y, Jin X, Wang H, et al. Inhibition of lysyl oxidase expression by dextran sulfate affects invasion and migration of gastric cancer cells. Int J Mol Med. 2018;42:2737-2749 pubmed publisher |
| Zhang X, Li Y, Ma Y, Yang L, Wang T, Meng X, et al. Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress. J Exp Clin Cancer Res. 2018;37:216 pubmed publisher |
| Xu L, Sun W, Jia A, Qiu L, Xiao B, Mu L, et al. MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α. J Inflamm (Lond). 2018;15:15 pubmed publisher |
| Pan F, Li W, Yang W, Yang X, Liu S, Li X, et al. Anterior gradient 2 as a supervisory marker for tumor vessel normalization induced by anti-angiogenic treatment. Oncol Lett. 2018;16:3083-3091 pubmed publisher |
| Yang J, Li W, Luo L, Jiang M, Zhu C, Qin B, et al. Hypoxic tumor therapy by hemoglobin-mediated drug delivery and reversal of hypoxia-induced chemoresistance. Biomaterials. 2018;182:145-156 pubmed publisher |
| Yang Y, Cao Y, Chen L, Liu F, Qi Z, Cheng X, et al. Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells. Cancer Med. 2018;7:4610-4618 pubmed publisher |
| Ma S, Lu C, Yang L, Wang J, Wang B, Cai H, et al. ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis. J Exp Clin Cancer Res. 2018;37:183 pubmed publisher |
| Zhu G, Zhou L, Liu H, Shan Y, Zhang X. MicroRNA-224 Promotes Pancreatic Cancer Cell Proliferation and Migration by Targeting the TXNIP-Mediated HIF1α Pathway. Cell Physiol Biochem. 2018;48:1735-1746 pubmed publisher |
| Licon Munoz Y, Fordyce C, Hayek S, Parra K. V-ATPase-dependent repression of androgen receptor in prostate cancer cells. Oncotarget. 2018;9:28921-28934 pubmed publisher |
| Yang B, Cheng H, Wang L, Fu J, Zhang G, Guan D, et al. Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes. Toxicol Appl Pharmacol. 2018;355:189-197 pubmed publisher |
| Alvarez Garcia O, Matsuzaki T, Olmer M, Miyata K, Mokuda S, Sakai D, et al. FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration. Aging Cell. 2018;17:e12800 pubmed publisher |
| Li Q, Li Y, Li J, Ma Y, Dai W, Mo S, et al. FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis. Int J Biol Sci. 2018;14:726-735 pubmed publisher |
| Li Q, Li Y, Liang L, Li J, Luo D, Liu Q, et al. Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis. Cell Commun Signal. 2018;16:26 pubmed publisher |
| Chen X, Wu L, Li D, Xu Y, Zhang L, Niu K, et al. Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1?. Cancer Med. 2018;7:3834-3847 pubmed publisher |
| Kanda M, Tanaka H, Shimizu D, Miwa T, Umeda S, Tanaka C, et al. SYT7 acts as a driver of hepatic metastasis formation of gastric cancer cells. Oncogene. 2018;37:5355-5366 pubmed publisher |
| Geng W, Qin F, Ren J, Xiao S, Wang A. Mini-peptide RPL41 attenuated retinal neovascularization by inducing degradation of ATF4 in oxygen-induced retinopathy mice. Exp Cell Res. 2018;369:243-250 pubmed publisher |
| Tang D, Zhang J, Yan T, Wei J, Jiang X, Zhang D, et al. FG-4592 Accelerates Cutaneous Wound Healing by Epidermal Stem Cell Activation via HIF-1α Stabilization. Cell Physiol Biochem. 2018;46:2460-2470 pubmed publisher |
| Imamura T, Shimamura M, Ogawa T, Minagawa T, Nagai T, Silwal Gautam S, et al. Biofabricated Structures Reconstruct Functional Urinary Bladders in Radiation-Injured Rat Bladders. Tissue Eng Part A. 2018;24:1574-1587 pubmed publisher |
| Song X, Yang C, Zhang H, Wang J, Sun X, Hu L, et al. Hypoxia-Inducible Factor-1? (HIF-1?) Expression on Endothelial Cells in Juvenile Nasopharyngeal Angiofibroma: A Review of 70 cases and Tissue Microarray Analysis. Ann Otol Rhinol Laryngol. 2018;127:357-366 pubmed publisher |
| Liu S, Yin Y, Yu R, Li Y, Zhang W. R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating β-catenin. Biochem Biophys Res Commun. 2018;499:59-65 pubmed publisher |
| Pang H, Yue S, Tang Y, Chen Y, Tan Y, Cao Y, et al. Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia. Front Pharmacol. 2018;9:165 pubmed publisher |
| Xie Z, Guo W, Guo N, HuangFu M, Liu H, Lin M, et al. Targeting tumor hypoxia with stimulus-responsive nanocarriers in overcoming drug resistance and monitoring anticancer efficacy. Acta Biomater. 2018;71:351-362 pubmed publisher |
| Cheng Z, Liu L, Wang Z, Cai Y, Xu Q, Chen P. Hypoxia Activates Src and Promotes Endocytosis Which Decreases MMP-2 Activity and Aggravates Renal Interstitial Fibrosis. Int J Mol Sci. 2018;19: pubmed publisher |
| Guo X, Qu J, Zhu C, Li W, Luo L, Yang J, et al. Synchronous delivery of oxygen and photosensitizer for alleviation of hypoxia tumor microenvironment and dramatically enhanced photodynamic therapy. Drug Deliv. 2018;25:585-599 pubmed publisher |
| Li L, Liang Y, Kang L, Liu Y, Gao S, Chen S, et al. Transcriptional Regulation of the Warburg Effect in Cancer by SIX1. Cancer Cell. 2018;33:368-385.e7 pubmed publisher |
| Li Y, Wang M, Zhi P, You J, Gao J. Metformin synergistically suppress tumor growth with doxorubicin and reverse drug resistance by inhibiting the expression and function of P-glycoprotein in MCF7/ADR cells and xenograft models. Oncotarget. 2018;9:2158-2174 pubmed publisher |
| Chai W, Chen L, Lian X, Zhang Z. Anti-glioma Efficacy and Mechanism of Action of Tripolinolate A from Tripolium pannonicum. Planta Med. 2018;84:786-794 pubmed publisher |
| Qiu F, Tong H, Wang Y, Tao J, Wang H, Chen L. Recombinant human maspin inhibits high glucose-induced oxidative stress and angiogenesis of human retinal microvascular endothelial cells via PI3K/AKT pathway. Mol Cell Biochem. 2018;446:127-136 pubmed publisher |
| Zhang F, Lu S, He J, Jin H, Wang F, Wu L, et al. Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α. Theranostics. 2018;8:610-626 pubmed publisher |
| Zhang X, Liu Z, Xiao Q, Zeng C, Lai C, Fan X, et al. Donor Treatment With a Hypoxia-Inducible Factor-1 Agonist Prevents Donation After Cardiac Death Liver Graft Injury in a Rat Isolated Perfusion Model. Artif Organs. 2018;42:280-289 pubmed publisher |
| Zhang C, Bian M, Chen X, Jin H, Zhao S, Yang X, et al. Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF-1α signaling. J Cell Biochem. 2018;119:2258-2268 pubmed publisher |
| Faget J, Groeneveld S, Boivin G, Sankar M, Zangger N, Garcia M, et al. Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer. Cell Rep. 2017;21:3190-3204 pubmed publisher |
| Guo X, Xu S, Gao X, Wang J, Xue H, Chen Z, et al. Macrophage migration inhibitory factor promotes vasculogenic mimicry formation induced by hypoxia via CXCR4/AKT/EMT pathway in human glioblastoma cells. Oncotarget. 2017;8:80358-80372 pubmed publisher |
| Qu J, Guo X, Li W, Hou W, Zhang H, Luo L, et al. Preparation of artificial red cell and its application on alleviation of tumor hypoxia. Colloids Surf B Biointerfaces. 2017;160:446-454 pubmed publisher |
| Wang R, Ma J, Wang M, Cui J, Wu W, Liu R, et al. A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway. Cell Physiol Biochem. 2017;43:1152-1167 pubmed publisher |
| Ni W, Yang Z, Qi W, Cui C, Cui Y, Xuan Y. Gli1 is a potential cancer stem cell marker and predicts poor prognosis in ductal breast carcinoma. Hum Pathol. 2017;69:38-45 pubmed publisher |
| Shang Y, Chen H, Ye J, Wei X, Liu S, Wang R. HIF-1?/Ascl2/miR-200b regulatory feedback circuit modulated the epithelial-mesenchymal transition (EMT) in colorectal cancer cells. Exp Cell Res. 2017;360:243-256 pubmed publisher |
| Pan F, Yang W, Li W, Yang X, Liu S, Li X, et al. Conjugation of gold nanoparticles and recombinant human endostatin modulates vascular normalization via interruption of anterior gradient 2-mediated angiogenesis. Tumour Biol. 2017;39:1010428317708547 pubmed publisher |
| Wang X, Liow S, Wu Q, Li C, Owh C, Li Z, et al. Codelivery for Paclitaxel and Bcl-2 Conversion Gene by PHB-PDMAEMA Amphiphilic Cationic Copolymer for Effective Drug Resistant Cancer Therapy. Macromol Biosci. 2017;17: pubmed publisher |
| Geng J, Wang L, Qu M, Song Y, Lin X, Chen Y, et al. Endothelial progenitor cells transplantation attenuated blood-brain barrier damage after ischemia in diabetic mice via HIF-1?. Stem Cell Res Ther. 2017;8:163 pubmed publisher |
| Yong Y, Zhang C, Gu Z, Du J, Guo Z, Dong X, et al. Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response. ACS Nano. 2017;11:7164-7176 pubmed publisher |
| Wang Y, Hu L, Zhang X, Zhao H, Xu H, Wei Y, et al. Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells. J Cancer. 2017;8:1400-1409 pubmed publisher |
| Zhu J, Wang H, Zhang X, Xie Y. Regulation of angiogenic behaviors by oxytocin receptor through Gli1-indcued transcription of HIF-1α in human umbilical vein endothelial cells. Biomed Pharmacother. 2017;90:928-934 pubmed publisher |
| Liu Y, Tang Q, Shao S, Chen Y, Chen W, Xu X. Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells. Int J Biol Sci. 2017;13:327-338 pubmed publisher |
| Liu W, Zhang B, Hu Q, Qin Y, Xu W, Shi S, et al. A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism. Int J Oncol. 2017;50:1792-1800 pubmed publisher |
| Tang D, Yan T, Zhang J, Jiang X, Zhang D, Huang Y. Notch1 Signaling Contributes to Hypoxia-induced High Expression of Integrin β1 in Keratinocyte Migration. Sci Rep. 2017;7:43926 pubmed publisher |
| Tong Y, Yang H, Xu X, Ruan J, Liang M, Wu J, et al. Effect of a hypoxic microenvironment after radiofrequency ablation on residual hepatocellular cell migration and invasion. Cancer Sci. 2017;108:753-762 pubmed publisher |
| Tang M, Yang Y, Yu J, Wu N, Chen P, Xu L, et al. Discordant mRNA and protein expression of CXCR4 under in vitro CoCl2-induced hypoxic conditions. Biochem Biophys Res Commun. 2017;484:285-291 pubmed publisher |
| Cai Q, Wang Z, Wang S, Weng M, Zhou D, Li C, et al. Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial-mesenchymal transition by regulating HIF-1α via miR-138. Open Biol. 2017;7: pubmed publisher |
| Cai X, Ding H, Liu Y, Pan G, Li Q, Yang Z, et al. Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer. Acta Biochim Biophys Sin (Shanghai). 2017;49:119-127 pubmed publisher |
| Zhang F, Hao M, Jin H, Yao Z, Lian N, Wu L, et al. Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis. Br J Pharmacol. 2017;174:409-423 pubmed publisher |
| Guo J, Luo X, Liang J, Xiao M, Sun X. Antiangiogenic Effects of Doxazosin on Experimental Choroidal Neovascularization in Mice. J Ocul Pharmacol Ther. 2017;33:50-56 pubmed publisher |
| Lu C, Xu W, Shao J, Zhang F, Chen A, Zheng S. Nrf2 Activation Is Required for Ligustrazine to Inhibit Hepatic Steatosis in Alcohol-Preferring Mice and Hepatocytes. Toxicol Sci. 2017;155:432-443 pubmed publisher |
| Magierowski M, Magierowska K, Hubalewska Mazgaj M, Adamski J, Bakalarz D, Sliwowski Z, et al. Interaction between endogenous carbon monoxide and hydrogen sulfide in the mechanism of gastroprotection against acute aspirin-induced gastric damage. Pharmacol Res. 2016;114:235-250 pubmed publisher |
| Su C, Hung K, Hung S, Tarn W. RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M. Mol Cell Biol. 2017;37: pubmed publisher |
| Zhang J, Zhang D, Yan T, Jiang X, Zhang C, Zhao L, et al. BNIP3 promotes the motility and migration of keratinocyte under hypoxia. Exp Dermatol. 2017;26:416-422 pubmed publisher |
| Gao F, Wang Y, Li S, Wang Z, Liu C, Sun D. Inhibition of p38 mitogen-activated protein kinases attenuates renal interstitial fibrosis in a murine unilateral ureteral occlusion model. Life Sci. 2016;167:78-84 pubmed publisher |
| Liang X, Yin G, Ma Y, Xu K, Liu J, Li J. The critical role of mast cell-derived hypoxia-inducible factor-1? in regulating mast cell function. J Pharm Pharmacol. 2016;68:1409-1416 pubmed publisher |
| Zhang Z, Li H, Zhou C, Li Q, Ma L, Zhang Z, et al. Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells. J Exp Clin Cancer Res. 2016;35:149 pubmed |
| Magierowski M, Magierowska K, Szmyd J, Surmiak M, Sliwowski Z, Kwiecien S, et al. Hydrogen Sulfide and Carbon Monoxide Protect Gastric Mucosa Compromised by Mild Stress Against Alendronate Injury. Dig Dis Sci. 2016;61:3176-3189 pubmed |
| Li W, Zhao X, Du B, Li X, Liu S, Yang X, et al. Gold Nanoparticle-Mediated Targeted Delivery of Recombinant Human Endostatin Normalizes Tumour Vasculature and Improves Cancer Therapy. Sci Rep. 2016;6:30619 pubmed publisher |
| Huang C, Lei K, Tsang N. Paper-based microreactor array for rapid screening of cell signaling cascades. Lab Chip. 2016;16:2911-20 pubmed publisher |
| Zhao C, Shi L, Pu H, Zhang Q. The Promoting Effect of Radiation on Glucose Metabolism in Breast Cancer Cells under the Treatment of Cobalt Chloride. Pathol Oncol Res. 2017;23:47-53 pubmed publisher |
| Dong K, Ni H, Wu M, Tang Z, Halim M, Shi D. ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes. Biochem Biophys Res Commun. 2016;476:204-211 pubmed publisher |
| Guo L, Zhu P, Jin X. Association between the expression of HIF-1? and VEGF and prognostic implications in primary liver cancer. Genet Mol Res. 2016;15: pubmed publisher |
| Ge X, Liu X, Lin F, Li P, Liu K, Geng R, et al. MicroRNA-421 regulated by HIF-1? promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer. Oncotarget. 2016;7:24466-82 pubmed publisher |
| Xu Y, Jin X, Huang Y, Dong J, Wang H, Wang X, et al. Inhibition of peritoneal metastasis of human gastric cancer cells by dextran sulphate through the reduction in HIF-1? and ITG?1 expression. Oncol Rep. 2016;35:2624-34 pubmed publisher |
| Zhang Y, Liu J, Wang S, Luo X, Li Y, Lv Z, et al. The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1α-dependent and -independent manners. Oncotarget. 2016;7:23740-56 pubmed publisher |
| Li P, Zhang D, Shen L, Dong K, Wu M, Ou Z, et al. Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells. Sci Rep. 2016;6:22831 pubmed publisher |
| Yang L, Xiao M, Li X, Tang Y, Wang Y. Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway. Int J Mol Med. 2016;37:734-42 pubmed publisher |
| Liu F, Wang B, Li L, Dong F, Chen X, Li Y, et al. Low-Dose Cadmium Upregulates VEGF Expression in Lung Adenocarcinoma Cells. Int J Environ Res Public Health. 2015;12:10508-21 pubmed publisher |
| Liu F, Zhang W, You X, Liu Y, Li Y, Wang Z, et al. The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer. Oncotarget. 2015;6:27199-213 pubmed publisher |
| Peng B, Liu F, Han R, Luo G, Cathopoulis T, Lu K, et al. Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells. Int J Biochem Cell Biol. 2015;66:45-58 pubmed publisher |
| Chen D, Dang B, Huang J, Chen M, Wu D, Xu M, et al. MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1α-TWIST signaling axis in breast cancer. Oncotarget. 2015;6:32701-12 pubmed publisher |
| Hu T, He N, Yang Y, Yin C, Sang N, Yang Q. DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas. J Exp Clin Cancer Res. 2015;34:22 pubmed publisher |
| Qu K, Yan Z, Wu Y, Chen Y, Qu P, Xu X, et al. Transarterial chemoembolization aggravated peritumoral fibrosis via hypoxia-inducible factor-1α dependent pathway in hepatocellular carcinoma. J Gastroenterol Hepatol. 2015;30:925-32 pubmed publisher |
| Hunt S, Gade T, Soulen M, Pickup S, Sehgal C. Antivascular ultrasound therapy: magnetic resonance imaging validation and activation of the immune response in murine melanoma. J Ultrasound Med. 2015;34:275-87 pubmed publisher |
