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- western blot; rat; loading ...; fig 6e
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| Yang F, Qu Q, Zhao C, Liu X, Yang P, Li Z, et al. Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice. Biomed Pharmacother. 2020;129:110479 pubmed publisher
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| Li Y, Zhang M, Li F. LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN. Histol Histopathol. 2020;:18245 pubmed publisher
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| Zhang Y, Chen L, Cao Y, Chen S, Xu C, Xing J, et al. LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway. J Gastric Cancer. 2020;20:139-151 pubmed publisher
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| Han B, Jiang L, Jiang P, Zhou D, Jia X, Li X, et al. Daucosterol linolenate from Sweet Potato Suppresses MCF7-Xenograft-Tumor Growth through Regulating PI3K/AKT Pathway. Planta Med. 2020;86:767-775 pubmed publisher
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| Chen Y, Cao W, Wang L, Zhong T. AMPH1 functions as a tumour suppressor in ovarian cancer via the inactivation of PI3K/AKT pathway. J Cell Mol Med. 2020;: pubmed publisher
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| Li P, Ding L, Cao S, Feng X, Zhang Q, Chen Y, et al. Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells. J Ethnopharmacol. 2020;259:113015 pubmed publisher
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| Kang N, Cao S, Jiang B, Zhang Q, Donkor P, Zhu Y, et al. Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells. Toxicol In Vitro. 2020;67:104885 pubmed publisher
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| Li J, Ma J, Tian Y, Zhao P, Liu X, Dong H, et al. Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling. J Ethnopharmacol. 2020;257:112796 pubmed publisher
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| Xu H, Lin S, Gong Y, Huo Z, Zhao C, Zhu H, et al. Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model. Front Pharmacol. 2020;11:245 pubmed publisher
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| Pan H, Liu F, Wang J, Zhao M, Wang D, Jia C, et al. Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway. Mol Carcinog. 2020;59:575-589 pubmed publisher
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| Tan X, Zhang K, Xu J, Qu D, Chen L, Li J, et al. Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats. Food Chem Toxicol. 2020;137:111179 pubmed publisher
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| Xu M, Yu X, Meng X, Huang S, Zhang Y, Zhang A, et al. Inhibition of PDE4/PDE4B improves renal function and ameliorates inflammation in cisplatin-induced acute kidney injury. Am J Physiol Renal Physiol. 2020;318:F576-F588 pubmed publisher
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| Huang F, Chen J, Wang J, Zhu P, Lin W. Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway. Biomed Res Int. 2019;2019:8171989 pubmed publisher
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| Wang Z, Liang M, Li H, Cai L, Yang L. Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway. Int J Mol Sci. 2019;20: pubmed publisher
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| Wu Y, Lin S, Din Z, Su J, Liu C. Sinulariolide Inhibits Gastric Cancer Cell Migration and Invasion through Downregulation of the EMT Process and Suppression of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways. Mar Drugs. 2019;17: pubmed publisher
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| Bu T, Wang C, Jin H, Meng Q, Huo X, Sun H, et al. Organic anion transporters and PI3K-AKT-mTOR pathway mediate the synergistic anticancer effect of pemetrexed and rhein. J Cell Physiol. 2019;: pubmed publisher
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| Wang Y, He G, Wang F, Zhang C, Ge Z, Zheng X, et al. Aspirin inhibits adipogenesis of tendon stem cells and lipids accumulation in rat injury tendon through regulating PTEN/PI3K/AKT signalling. J Cell Mol Med. 2019;23:7535-7544 pubmed publisher
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| Huang X, Ni B, Mao Z, Xi Y, Chu X, Zhang R, et al. NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway. J Cell Mol Med. 2019;: pubmed publisher
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| Yang R, Zhou Y, Song W, Yin Z, He A, Ming Z. Pharmacological actions of neferine in the modulation of human platelet function. Eur J Pharmacol. 2019;:172626 pubmed publisher
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| Wang F, Lei X, Zhao Y, Yu Q, Li Q, Zhao H, et al. Protective role of thymoquinone in sepsis-induced liver injury in BALB/c mice. Exp Ther Med. 2019;18:1985-1992 pubmed publisher
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| He S, Yu Q, He Y, Hu R, Xia S, He J. Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers. Poult Sci. 2019;: pubmed publisher
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| Li W, Jiang Y, Wang Y, Zhao M, Hou G, Hu H, et al. Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells. Chin J Integr Med. 2019;: pubmed publisher
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| Zhang D, Ren L, Zhao M, Yang C, Liu X, Zhang H, et al. Role of Tim-3 in Decidual Macrophage Functional Polarization During Abnormal Pregnancy With Toxoplasma gondii Infection. Front Immunol. 2019;10:1550 pubmed publisher
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| Zhao H, Wang Y, Liu J, Guo M, Fei D, Yu H, et al. The cardiotoxicity of the common carp (Cyprinus carpio) exposed to environmentally relevant concentrations of arsenic and subsequently relieved by zinc supplementation. Environ Pollut. 2019;253:741-748 pubmed publisher
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| Li S, Yao M, Niu C, Liu D, Tang Z, Gu C, et al. Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel. Biochem Biophys Res Commun. 2019;516:1066-1072 pubmed publisher
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| Wang F, Chang C, Li R, Zhang Z, Jiang H, Zeng N, et al. Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells. Toxicology. 2019;: pubmed publisher
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| Wu X, Ansari A, Pang X, Li H, Zhang Z, Luo Y, et al. Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice. Arch Immunol Ther Exp (Warsz). 2019;: pubmed publisher
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| Liu Y, Wang H, Liu N, Du J, Lan X, Qi X, et al. Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3β pathway. Life Sci. 2019;: pubmed publisher
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| Zhao H, Wang Y, Fei D, Guo M, Yang X, Mu M, et al. Destruction of redox and mitochondrial dynamics co-contributes to programmed cell death in chicken kidney under arsenite or/and copper (II) exposure. Ecotoxicol Environ Saf. 2019;179:167-174 pubmed publisher
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| Li Y, Guo Y, Feng Z, Bergan R, Li B, Qin Y, et al. Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells. Nutr Cancer. 2019;71:1007-1018 pubmed publisher
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| Zheng R, Huang S, Zhu J, Lin W, Xu H, Zheng X. Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears. Cell Tissue Res. 2019;: pubmed publisher
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| Yang P, Zhou Y, Xia Q, Yao L, Chang X. Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation. Biol Pharm Bull. 2019;42:721-727 pubmed publisher
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| Zhang B, Liu P, Zhou Y, Chen Z, He Y, Mo M, et al. Dihydroartemisinin attenuates renal fibrosis through regulation of fibroblast proliferation and differentiation. Life Sci. 2019;223:29-37 pubmed publisher
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| Xie L, Dai H, Li M, Yang W, Yu G, Wang X, et al. MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-β-catenin pathways. J Cell Mol Med. 2019;23:3386-3401 pubmed publisher
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| Zhou T, Sun Y, Wang Y, Chen X, Zhuo L, Bu L, et al. Umbilical Cord Blood Mesenchymal Stem Cells Enhance Lipopolysaccharide-Induced IL-10 and IL-37 Production in THP-1 Cells. Inflammation. 2019;42:987-993 pubmed publisher
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| Xie L, Li M, Liu D, Wang X, Wang P, Dai H, et al. Secalonic Acid-F, a Novel Mycotoxin, Represses the Progression of Hepatocellular Carcinoma via MARCH1 Regulation of the PI3K/AKT/β-catenin Signaling Pathway. Molecules. 2019;24: pubmed publisher
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| Ren Z, Xiao W, Zeng Y, Liu M, Li G, Tang Z, et al. Fibroblast growth factor-21 alleviates hypoxia/reoxygenation injury in H9c2 cardiomyocytes by promoting autophagic flux. Int J Mol Med. 2019;43:1321-1330 pubmed publisher
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| Liang H, Mokrani A, Chisomo Kasiya H, Ji K, Ge X, Ren M, et al. Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala. Fish Physiol Biochem. 2019;45:719-732 pubmed publisher
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| Zhu B, Long Y, Luo W, Yan Z, Lai Y, Zhao L, et al. MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation. Brain. 2019;142:176-192 pubmed publisher
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| Zhang D, Zhang J, Zeng J, Li Z, Zuo H, Huang C, et al. Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo. J Biomed Nanotechnol. 2019;15:288-300 pubmed publisher
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| Jiang T, Zhou M, Fan J. Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro. Onco Targets Ther. 2018;11:7865-7872 pubmed publisher
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| Cen B, Wei Y, Huang W, Teng M, He S, Li J, et al. An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo. Mol Ther Nucleic Acids. 2018;13:220-232 pubmed publisher
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| Batool S, Joseph T, Hussain M, Vuai M, Khinsar K, Din S, et al. LP1 from Lentinula edodes C91-3 Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901. Int J Mol Sci. 2018;19: pubmed publisher
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| Sun D, Zhang F, Qian J, Shen W, Fan H, Tan J, et al. 4'-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling. Chem Biol Interact. 2018;296:26-33 pubmed publisher
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| Liu Y, Fan D. Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model. Food Funct. 2018;9:5513-5527 pubmed publisher
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| Zou W, Ding F, Niu C, Fu Z, Liu S. Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway. Biochem Biophys Res Commun. 2018;503:3212-3218 pubmed publisher
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| Guo S, Liang X, Guo M, Zhang X, Li Z. Migration inhibition of water stress proteins from Nostoc commune Vauch. via activation of autophagy in DLD-1 cells. Int J Biol Macromol. 2018;119:669-676 pubmed publisher
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| Chen S, Wang L, Sun K, Liu Y, Guan X, Zong Z, et al. LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein. Biochim Biophys Acta Mol Basis Dis. 2018;1864:3013-3021 pubmed publisher
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| Feng J, Niu P, Chen K, Wu L, Liu T, Xu S, et al. Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury. Exp Ther Med. 2018;15:4599-4614 pubmed publisher
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| Wang A, Li Y, Zhao Q, Fan L. Formononetin inhibits colon carcinoma cell growth and invasion by microRNA?149?mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways. Mol Med Rep. 2018;17:7721-7729 pubmed publisher
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| Zhu X, Li Z, Li T, Long F, Lv Y, Liu L, et al. Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma. Biomed Pharmacother. 2018;102:502-509 pubmed publisher
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| Zhang H, Cao Y, Chen Y, Li G, Yu H. Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway. Oncol Lett. 2018;15:5739-5743 pubmed publisher
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| Sun S, Wu Y, Guo W, Yu F, Kong L, Ren Y, et al. STAT3/HOTAIR Signaling Axis Regulates HNSCC Growth in an EZH2-dependent Manner. Clin Cancer Res. 2018;24:2665-2677 pubmed publisher
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| Deng T, Zhang Y, Wu Y, Ma P, Duan J, Qin W, et al. Dibutyl phthalate exposure aggravates type 2 diabetes by disrupting the insulin-mediated PI3K/AKT signaling pathway. Toxicol Lett. 2018;290:1-9 pubmed publisher
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| Che C, Liu J, Yang J, Ma L, Bai N, Zhang Q. Osteopontin is essential for IL-1β production and apoptosis in peri-implantitis. Clin Implant Dent Relat Res. 2018;20:384-392 pubmed publisher
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| Yin N, Wang Y, Lu X, Liu R, Zhang L, Zhao W, et al. hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway. Stem Cell Res Ther. 2018;9:37 pubmed publisher
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| Jia Y, Lu H, Peng Y, Zhang B, Gong X, Su J, et al. Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. Int Immunopharmacol. 2018;56:105-112 pubmed publisher
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| Gao Y, Yu H, Liu Y, Liu X, Zheng J, Ma J, et al. Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis. Cell Physiol Biochem. 2018;45:131-147 pubmed publisher
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| Xiao Y, Tian C, Huang T, Han B, Wang M, Ma H, et al. 8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo. Life Sci. 2018;192:259-269 pubmed publisher
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| Sun X, Li J, Zhao H, Wang Y, Liu J, Shao Y, et al. Synergistic effect of copper and arsenic upon oxidative stress, inflammation and autophagy alterations in brain tissues of Gallus gallus. J Inorg Biochem. 2018;178:54-62 pubmed publisher
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| Zhao J, Zhu J, Lv X, Xing J, Liu S, Chen C, et al. Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-?B/COX-2 signaling pathways. Onco Targets Ther. 2017;10:5471-5482 pubmed publisher
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| Sun K, Wu D, Chen S, Zhao Y, Zong Z. LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway. Apoptosis. 2017;22:1543-1552 pubmed publisher
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| Wu L, Zhang Q, Mo W, Feng J, Li S, Li J, et al. Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways. Sci Rep. 2017;7:9289 pubmed publisher
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| Xu S, Wu L, Zhang Q, Feng J, Li S, Li J, et al. Pretreatment with propylene glycol alginate sodium sulfate ameliorated concanavalin A-induced liver injury by regulating the PI3K/Akt pathway in mice. Life Sci. 2017;185:103-113 pubmed publisher
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| Wang L, Xiu Y, Chen X, Sun K, Chen S, Wu D, et al. The transcription factor FOXA1 induces epithelial ovarian cancer tumorigenesis and progression. Tumour Biol. 2017;39:1010428317706210 pubmed publisher
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| Zhou W, Liu L, Xue Y, Zheng J, Liu X, Ma J, et al. Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway. Front Mol Neurosci. 2017;10:68 pubmed publisher
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| Ren K, Lu Y, Mo Z, Liu X, Tang Z, Jiang Y, et al. ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs. J Physiol Biochem. 2017;73:287-296 pubmed publisher
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| Yin K, Zhu R, Wang S, Zhao R. Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells. Stem Cells Dev. 2017;26:762-775 pubmed publisher
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| Huang T, Xiao Y, Yi L, Li L, Wang M, Tian C, et al. Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo. Sci Rep. 2017;7:38524 pubmed publisher
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| Lou J, Teng Z, Zhang L, Yang J, Ma L, Wang F, et al. ?-Caryophyllene/Hydroxypropyl-?-Cyclodextrin Inclusion Complex Improves Cognitive Deficits in Rats with Vascular Dementia through the Cannabinoid Receptor Type 2 -Mediated Pathway. Front Pharmacol. 2017;8:2 pubmed publisher
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| Yang Y, Wang F, Li S, Tiao M, Huang Y. MicroRNA-29a Alleviates Bile Duct Ligation Exacerbation of Hepatic Fibrosis in Mice through Epigenetic Control of Methyltransferases. Int J Mol Sci. 2017;18: pubmed publisher
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| Huang C, Lei K, Tsang N. Paper-based microreactor array for rapid screening of cell signaling cascades. Lab Chip. 2016;16:2911-20 pubmed publisher
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| Liu J, Huang W, Ren C, Wen Q, Liu W, Yang X, et al. Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways. Sci Rep. 2015;5:11614 pubmed publisher
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| Huang W, Liu J, Feng X, Chen H, Zeng L, Huang G, et al. DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway. Med Oncol. 2015;32:115 pubmed publisher
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| Li X, Zou K, Gou J, Du Q, Li D, He X, et al. Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells. Med Oncol. 2015;32:72 pubmed publisher
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