This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
TLR4
catalog :
19811-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, pigs
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section
citations: 140
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; rat; 1:200; loading ...; fig 5c
Xia Y, Xue M, Wang Y, Huang Z, Huang C. Electroacupuncture Alleviates Spared Nerve Injury-Induced Neuropathic Pain And Modulates HMGB1/NF-κB Signaling Pathway In The Spinal Cord. J Pain Res. 2019;12:2851-2863 pubmed publisher
  • western blot; pigs ; 1:500; loading ...; fig 4b
Sun P, Sun N, Yin W, Sun Y, Fan K, Guo J, et al. Matrine inhibits IL-1β secretion in primary porcine alveolar macrophages through the MyD88/NF-κB pathway and NLRP3 inflammasome. Vet Res. 2019;50:53 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 3b
Shi H, Yao R, Lian S, Liu P, Liu Y, Yang Y, et al. Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure. Stress. 2019;22:366-376 pubmed publisher
  • ELISA; human; fig 1a
Su J, Zhou H, Liu X, Nilsson J, Fredrikson G, Zhao M. oxLDL antibody inhibits MCP-1 release in monocytes/macrophages by regulating Ca2+ /K+ channel flow. J Cell Mol Med. 2017;21:929-940 pubmed publisher
Liang T, Guo Y, Li M, Ding C, Sang S, Zhou T, et al. Cytoskeleton Protein 4.1R Regulates B cell fate by Modulating the Canonical NF-κB Pathway. Immunology. 2020;: pubmed publisher
Ge X, Meng X, Fei D, Kang K, Wang Q, Zhao M. Lycorine attenuates lipopolysaccharide-induced acute lung injury through the HMGB1/TLRs/NF-κB pathway. 3 Biotech. 2020;10:369 pubmed publisher
Zhuang C, Liu G, Barkema H, Zhou M, Xu S, Ur Rahman S, et al. Selenomethionine Suppressed TLR4/NF-κB Pathway by Activating Selenoprotein S to Alleviate ESBL Escherichia coli-Induced Inflammation in Bovine Mammary Epithelial Cells and Macrophages. Front Microbiol. 2020;11:1461 pubmed publisher
Zheng P, Tian X, Zhang W, Yang Z, Zhou J, Zheng J, et al. Rhein Suppresses Neuroinflammation via Multiple Signaling Pathways in LPS-Stimulated BV2 Microglia Cells. Evid Based Complement Alternat Med. 2020;2020:7210627 pubmed publisher
Liu Z, Ye S, Zhong X, Wang W, Lai C, Yang W, et al. Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy. Mol Med Rep. 2020;22:2373-2385 pubmed publisher
Lan Y, Yan R, Shan W, Chu J, Sun R, Wang R, et al. Salvianic acid A alleviates chronic alcoholic liver disease by inhibiting HMGB1 translocation via down-regulating BRD4. J Cell Mol Med. 2020;24:8518-8531 pubmed publisher
Li X, Liu Y, Wang Y, Li X, Liu X, Guo M, et al. Sucralose Promotes Colitis-Associated Colorectal Cancer Risk in a Murine Model Along With Changes in Microbiota. Front Oncol. 2020;10:710 pubmed publisher
Gao W, Feng Z, Zhang S, Wu B, Geng X, Fan G, et al. Anti-Inflammatory and Antioxidant Effect of Eucommia ulmoides Polysaccharide in Hepatic Ischemia-Reperfusion Injury by Regulating ROS and the TLR-4-NF-κB Pathway. Biomed Res Int. 2020;2020:1860637 pubmed publisher
Gan P, Ding L, Hang G, Xia Q, Huang Z, Ye X, et al. Oxymatrine Attenuates Dopaminergic Neuronal Damage and Microglia-Mediated Neuroinflammation Through Cathepsin D-Dependent HMGB1/TLR4/NF-κB Pathway in Parkinson's Disease. Front Pharmacol. 2020;11:776 pubmed publisher
Guan L, Li C, Zhang Y, Gong J, Wang G, Tian P, et al. Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome. Life Sci. 2020;256:117935 pubmed publisher
Wei A, Xiao H, Xu G, Yu X, Guo J, Jing Z, et al. Hyperoside Protects Human Umbilical Vein Endothelial Cells Against Anticardiolipin Antibody-Induced Injury by Activating Autophagy. Front Pharmacol. 2020;11:762 pubmed publisher
Wang G, Zuo T, Li R. The mechanism of Arhalofenate in alleviating hyperuricemia-Activating PPARγ thereby reducing caspase-1 activity. Drug Dev Res. 2020;: pubmed publisher
Sun Z, Nyanzu M, Yang S, Zhu X, Wang K, Ru J, et al. VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice. Oxid Med Cell Longev. 2020;2020:7879629 pubmed publisher
Liu Y, Liang X, Zou Y, Peng Y, McClements D, Hu K. Resveratrol-loaded biopolymer core-shell nanoparticles: bioavailability and anti-inflammatory effects. Food Funct. 2020;11:4014-4025 pubmed publisher
Zuo B, Qi H, Lu Z, Chen L, Sun B, Yang R, et al. Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice. Nat Commun. 2020;11:1790 pubmed publisher
Lin M, Huang J, Chen W, Fan Z, Qin X. The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis. Iran J Immunol. 2020;17:52-63 pubmed publisher
Lin L, Wang D, Qu S, Zhao H, Lin Y. miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition. Drug Des Devel Ther. 2020;14:1127-1141 pubmed publisher
Ma L, Sun Y, Li D, Li H, Jin X, Ren D. Overexpressed ITGA2 contributes to paclitaxel resistance by ovarian cancer cells through the activation of the AKT/FoxO1 pathway. Aging (Albany NY). 2020;12:5336-5351 pubmed publisher
Jiang H, Zeng L, Dong X, Guo S, Xing J, Li Z, et al. Tilianin Extracted From Dracocephalum moldavica L. Induces Intrinsic Apoptosis and Drives Inflammatory Microenvironment Response on Pharyngeal Squamous Carcinoma Cells via Regulating TLR4 Signaling Pathways. Front Pharmacol. 2020;11:205 pubmed publisher
Gao L, Qian B, Chen H, Wang A, Li Q, Li J, et al. Hic-5 deficiency attenuates hepatic ischemia reperfusion injury through TLR4/NF-κB signaling pathways. Life Sci. 2020;249:117517 pubmed publisher
Liu Z, Cao K, Liao Z, Chen Y, Lei X, Wei Q, et al. Monophosphoryl lipid A alleviated radiation-induced testicular injury through TLR4-dependent exosomes. J Cell Mol Med. 2020;24:3917-3930 pubmed publisher
Li S, Huang N, Dang X, Li L, Li Z, Zhang C, et al. A Comparison of Splenic Pathologic Change and Immune Function in HBV-Related Portal Hypertension and Chinese Budd-Chiari Syndrome Patients with Hypersplenism. Viral Immunol. 2020;33:112-121 pubmed publisher
Chen Y, Feng B, Yuan Y, Hu J, Zhao W, Jiang H, et al. Aloe Emodin Reduces Cardiac Inflammation Induced by a High-Fat Diet through the TLR4 Signaling Pathway. Mediators Inflamm. 2020;2020:6318520 pubmed publisher
Zhang P, Yi L, Qu S, Dai J, Li X, Liu B, et al. The Biomarker TCONS_00016233 Drives Septic AKI by Targeting the miR-22-3p/AIFM1 Signaling Axis. Mol Ther Nucleic Acids. 2020;19:1027-1042 pubmed publisher
Wen S, Li X, Ling Y, Chen S, Deng Q, Yang L, et al. HMGB1-associated necroptosis and Kupffer cells M1 polarization underlies remote liver injury induced by intestinal ischemia/reperfusion in rats. FASEB J. 2020;34:4384-4402 pubmed publisher
Wang D, Zhou M, Wang Y, Sun S. Suppression of high-mobility group box 1 ameliorates xerostomia in a Sjögren syndrome-triggered mouse model. Can J Physiol Pharmacol. 2020;98:351-356 pubmed publisher
Tian C, Gao F, Li X, Li Z. Icariside II attenuates eosinophils-induced airway inflammation and remodeling via inactivation of NF-κB and STAT3 in an asthma mouse model. Exp Mol Pathol. 2020;113:104373 pubmed publisher
Qu Z, Chen Y, Luo Z, Shen X, Hu Y. 7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway. J Pharm Pharmacol. 2020;72:385-395 pubmed publisher
Dong M, Yu H, Wang Y, Sun C, Chang Y, Yin Q, et al. Critical role of toll-like receptor 4 (TLR4) in ricin toxin-induced inflammatory responses in macrophages. Toxicol Lett. 2020;321:54-60 pubmed publisher
Su H, Zhang C, Zou X, Lu F, Zeng Y, Guan H, et al. Jiao-tai-wan inhibits inflammation of the gut-brain-axis and attenuates cognitive impairment in insomnic rats. J Ethnopharmacol. 2020;250:112478 pubmed publisher
Zhang Q, Zhao S, Zheng W, Fu H, Wu T, Hu F. Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome. Biosci Biotechnol Biochem. 2020;84:134-142 pubmed publisher
Jin W, Zhang Y, Xue Y, Han X, Zhang X, Ma Z, et al. Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis. Naunyn Schmiedebergs Arch Pharmacol. 2020;393:13-23 pubmed publisher
Shao Q, Jiang C, Xia Y, Zhao M, Zhang Q, Jin B, et al. Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway. Int J Clin Exp Pathol. 2019;12:867-875 pubmed
Li W, Mao X, Wu H, Guo M, Su X, Lu J, et al. Deciphering the chemical profile and pharmacological mechanisms of Baihu-Guizhi decoction using ultra-fast liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry coupled with network pharmacology-based investigation. Phytomedicine. 2019;67:153156 pubmed publisher
Xue M, Liang H, Ji X, Liu Y, Ge Y, Hou L, et al. Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology. Nutr Metab (Lond). 2019;16:87 pubmed publisher
Li Y, Wang C, Lu J, Huang K, Han Y, Chen J, et al. PPAR δ inhibition protects against palmitic acid-LPS induced lipidosis and injury in cultured hepatocyte L02 cell. Int J Med Sci. 2019;16:1593-1603 pubmed publisher
Li Y, Niu M, Zhao A, Kang W, Chen Z, Luo N, et al. CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson's disease. J Neuroinflammation. 2019;16:263 pubmed publisher
Li Z, Chen D, Jia Y, Feng Y, Wang C, Tong Y, et al. Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4/NF-κB/NLRP3 Inflammasome Pathway. Oxid Med Cell Longev. 2019;2019:6565283 pubmed publisher
Du Y, Qian B, Gao L, Tan P, Chen H, Wang A, et al. Aloin Preconditioning Attenuates Hepatic Ischemia/Reperfusion Injury via Inhibiting TLR4/MyD88/NF-κB Signal Pathway In Vivo and In Vitro. Oxid Med Cell Longev. 2019;2019:3765898 pubmed publisher
He Y, Li X, Yu H, Ge Y, Liu Y, Qin X, et al. The Functional Role of Fecal Microbiota Transplantation on Dextran Sulfate Sodium-Induced Colitis in Mice. Front Cell Infect Microbiol. 2019;9:393 pubmed publisher
Miao X, Zheng L, Zhao Z, Su S, Zhu Y, Guo J, et al. Protective Effect and Mechanism of Boswellic Acid and Myrrha Sesquiterpenes with Different Proportions of Compatibility on Neuroinflammation by LPS-Induced BV2 Cells Combined with Network Pharmacology. Molecules. 2019;24: pubmed publisher
Guo X, Shi Y, Du P, Wang J, Han Y, Sun B, et al. HMGB1/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA. Life Sci. 2019;239:117020 pubmed publisher
Zheng L, Zhu Q, Xu C, Li M, Li H, Yi P, et al. Glycyrrhizin mitigates radiation-induced acute lung injury by inhibiting the HMGB1/TLR4 signalling pathway. J Cell Mol Med. 2019;: pubmed publisher
Ye S, Zheng Q, Zhou Y, Bai B, Yang D, Zhao Z. Chlojaponilactone B Attenuates Lipopolysaccharide-Induced Inflammatory Responses by Suppressing TLR4-Mediated ROS Generation and NF-κB Signaling Pathway. Molecules. 2019;24: pubmed publisher
Lu L, Wu C, Lu B, Xie D, Wang Z, Bahaji Azami N, et al. BabaoDan cures hepatic encephalopathy by decreasing ammonia levels and alleviating inflammation in rats. J Ethnopharmacol. 2019;:112301 pubmed publisher
Wang Y, Zhu X, Yuan S, Wen S, Liu X, Wang C, et al. TLR4/NF-κB Signaling Induces GSDMD-Related Pyroptosis in Tubular Cells in Diabetic Kidney Disease. Front Endocrinol (Lausanne). 2019;10:603 pubmed publisher
Huang X, Ni B, Mao Z, Xi Y, Chu X, Zhang R, et al. NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway. J Cell Mol Med. 2019;: pubmed publisher
Wang Y, Xu X, Hu P, Jia N, Ji S, Yuan H. Effect of Toll-Like Receptor 4/Myeloid Differentiation Factor 88 Inhibition by Salvianolic Acid B on Neuropathic Pain After Spinal Cord Injury in Mice. World Neurosurg. 2019;132:e529-e534 pubmed publisher
Gong D, Wang L, Yang Y, Zhang J, Liu X. Diabetes aggravates renal ischemia and reperfusion injury in rats by exacerbating oxidative stress, inflammation, and apoptosis. Ren Fail. 2019;41:750-761 pubmed publisher
Zhang J, Harada Y, Hayashi Y. A TLR-CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice. Sci Rep. 2019;9:12003 pubmed publisher
Wang S, Cui Y, Xu J, Gao H. miR-140-5p Attenuates Neuroinflammation and Brain Injury in Rats Following Intracerebral Hemorrhage by Targeting TLR4. Inflammation. 2019;42:1869-1877 pubmed publisher
Zhu L, Li L, Wang X, Pan L, Mei Y, Fu Y, et al. M1 macrophages regulate TLR4/AP1 via paracrine to promote alveolar bone destruction in periodontitis. Oral Dis. 2019;: pubmed publisher
Sun S, Cai B, Li Y, Su W, Zhao X, Gong B, et al. HMGB1 and Caveolin-1 related to RPE cell senescence in age-related macular degeneration. Aging (Albany NY). 2019;11:4323-4337 pubmed publisher
Zhang H, Wang J, Yang L, Yang W, Luo T, Yuan Y, et al. Effect of oleic acid on induction of steatosis and cytotoxicity in BRL 3A cells. J Cell Biochem. 2019;: pubmed publisher
Zhong X, Xiao Q, Liu Z, Wang W, Lai C, Yang W, et al. TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats. Mol Med Rep. 2019;20:2101-2110 pubmed publisher
Zhao J, Gao W, Cai X, Xu J, Zou D, Li Z, et al. Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease. Theranostics. 2019;9:2843-2855 pubmed publisher
Jin Y, Li Z, Chen H, Jiang X, Zhang Y, Wu F. Effect of dexmedetomidine on kidney injury in sepsis rats through TLR4/MyD88/NF-κB/iNOS signaling pathway. Eur Rev Med Pharmacol Sci. 2019;23:5020-5025 pubmed publisher
Wang C, Zhang M, Guo H, Yan J, Liu F, Chen J, et al. Human Milk Oligosaccharides Protect against Necrotizing Enterocolitis by Inhibiting Intestinal Damage via Increasing the Proliferation of Crypt Cells. Mol Nutr Food Res. 2019;:e1900262 pubmed publisher
Wang G, Xu B, Shi F, Du M, Li Y, Yu T, et al. Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-κB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response. Oxid Med Cell Longev. 2019;2019:7850324 pubmed publisher
Xu W, Hu G, Da Costa C, Tang J, Li Q, Du L, et al. Long noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis. Onco Targets Ther. 2019;12:3467-3480 pubmed publisher
Zheng J, He Y, Yu H, Liu Y, Ge Y, Li X, et al. Unconjugated bilirubin alleviates experimental ulcerative colitis by regulating intestinal barrier function and immune inflammation. World J Gastroenterol. 2019;25:1865-1878 pubmed publisher
Pan L, Niu W, Fang X, Liang W, Li H, Chen W, et al. Clostridium butyricum Strains Suppress Experimental Acute Pancreatitis by Maintaining Intestinal Homeostasis. Mol Nutr Food Res. 2019;:e1801419 pubmed publisher
Jia Y, Peng Y, Zhao Y, Cheng X, Zhou Y, Chai C, et al. Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs. J Agric Food Chem. 2019;: pubmed publisher
He Y, Yu H, Ge Y, Li X, Jiang M, Liu Y, et al. Bacterial β-glucuronidase alleviates dextran sulfate sodium-induced colitis in mice: A possible crucial new diagnostic and therapeutic target for inflammatory bowel disease. Biochem Biophys Res Commun. 2019;513:426-433 pubmed publisher
Zheng J, Fan R, Wu H, Yao H, Yan Y, Liu J, et al. Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation. Nat Commun. 2019;10:1604 pubmed publisher
Jiang W, Chen M, Xiao C, Yang W, Qin Q, Tan Q, et al. Triptolide Suppresses Growth of Breast Cancer by Targeting HMGB1 in Vitro and in Vivo. Biol Pharm Bull. 2019;42:892-899 pubmed publisher
Yang J, Shang B, Shi H, Zhu S, Lu G, Dai F. The role of toll-like receptor 4 and mast cell in the ameliorating effect of electroacupuncture on visceral hypersensitivity in rats. Neurogastroenterol Motil. 2019;31:e13583 pubmed publisher
Li Q, Wu C, Liu Z, Zhang H, Du Y, Liu Y, et al. Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38-/- Mice. J Immunol Res. 2019;2019:3737890 pubmed publisher
Leng B, Zhang Y, Liu X, Zhang Z, Liu Y, Wang H, et al. Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR. Mediators Inflamm. 2019;2019:1082497 pubmed publisher
Cheng Z, Zhang M, Ling C, Zhu Y, Ren H, Hong C, et al. Neuroprotective Effects of Ginsenosides against Cerebral Ischemia. Molecules. 2019;24: pubmed publisher
Yao E, Zhang G, Huang J, Yang X, Peng L, Huang X, et al. Immunomodulatory effect of oleoylethanolamide in dendritic cells via TRPV1/AMPK activation. J Cell Physiol. 2019;: pubmed publisher
Lv R, Du L, Liu X, Zhou F, Zhang Z, Zhang L. Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease. Life Sci. 2019;223:158-165 pubmed publisher
Adegoke E, Adeniran S, Zeng Y, Wang X, Wang H, Wang C, et al. Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells. J Appl Toxicol. 2019;39:832-843 pubmed publisher
Song Q, Zhang Y, Han X, Zhang Y, Zhang X, Gao Y, et al. Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro. Biomed Pharmacother. 2019;109:945-956 pubmed publisher
Xu B, Zang S, Li S, Guo J, Wang J, Wang D, et al. HMGB1-mediated differential response on hippocampal neurotransmitter disorder and neuroinflammation in adolescent male and female mice following cold exposure. Brain Behav Immun. 2019;76:223-235 pubmed publisher
Sun J, Ren X, Kang Y, Dai H, Ding L, Tong N, et al. Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation via Adrenomedullin Receptors in Rats with Obesity-Related Hypertension. Neurosci Bull. 2019;35:34-46 pubmed publisher
Du Y, Gu X, Meng H, Aa N, Liu S, Peng C, et al. Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome. Am J Transl Res. 2018;10:4235-4246 pubmed
Liang S, Lv Z, Zhang J, Wang Y, Dong Y, Wang Z, et al. Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes. Front Pharmacol. 2018;9:1378 pubmed publisher
Chen Y, Wang L, Zhang L, Chen B, Yang L, Li X, et al. Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway. Front Cell Neurosci. 2018;12:372 pubmed publisher
Qiu Z, Yuan H, Li N, Yang X, Hu X, Su F, et al. Bidirectional effects of moxifloxacin on the pro‑inflammatory response in lipopolysaccharide‑stimulated mouse peritoneal macrophages. Mol Med Rep. 2018;18:5399-5408 pubmed publisher
Li R, Li J, Huang Y, Li H, Yan S, Lin J, et al. Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice. Int J Biol Sci. 2018;14:1411-1425 pubmed publisher
Tang S, Jiang X, Wu L, Chen S, Chen L, Jiang J, et al. Toll-like receptor 4 shRNA attenuates lipopolysaccharide-induced epithelial-mesenchymal transition of intrahepatic biliary epithelial cells in rats. Biomed Pharmacother. 2018;107:1210-1217 pubmed publisher
Wang Z, Ren J, Liu Q, Li J, Wu X, Wang W, et al. Hypermucoviscous Klebsiella pneumoniae infections induce platelet aggregation and apoptosis and inhibit maturation of megakaryocytes. Thromb Res. 2018;171:45-54 pubmed publisher
Wang P, Dai H, Zhang C, Tian J, Deng Y, Zhao M, et al. Evaluation of the effects of chlorpyrifos combined with lipopolysaccharide stress on neuroinflammation and spatial memory in neonatal rats. Toxicology. 2018;410:106-115 pubmed publisher
Zhang F, Dong H, Lv T, Jin K, Jin Y, Zhang X, et al. Moderate hypothermia inhibits microglial activation after traumatic brain injury by modulating autophagy/apoptosis and the MyD88-dependent TLR4 signaling pathway. J Neuroinflammation. 2018;15:273 pubmed publisher
Sun C, Chen Z, Wang H, Ding K. Tetrahydropalmatine Prevents High-Fat Diet-Induced Hyperlipidemia in Golden Hamsters (Mesocricetus Auratus). Med Sci Monit. 2018;24:6564-6572 pubmed publisher
Adegoke E, Wang C, Machebe N, Wang X, Wang H, Adeniran S, et al. Microcystin-leucine arginine (MC-LR) induced inflammatory response in bovine sertoli cell via TLR4/NF-kB signaling pathway. Environ Toxicol Pharmacol. 2018;63:115-126 pubmed publisher
Yang Y, Yang J, Liu X, Ding J, Li S, Guo X, et al. Down-Regulation of miR-327 Alleviates Ischemia/Reperfusion-Induced Myocardial Damage by Targeting RP105. Cell Physiol Biochem. 2018;49:1049-1063 pubmed publisher
Chen S, Lyu C, Zhou J, Huang S, Zhang Y, Liu G, et al. TLR4 signaling pathway mediates the LPS/ischemia-induced expression of monocytechemotactic protein-induced protein 1 in microglia. Neurosci Lett. 2018;686:33-40 pubmed publisher
Leng B, Tang F, Lü M, Zhang Z, Wang H, Zhang Y. Astragaloside IV improves vascular endothelial dysfunction by inhibiting the TLR4/NF-?B signaling pathway. Life Sci. 2018;209:111-121 pubmed publisher
Ning C, Gao X, Wang C, Huo X, Liu Z, Sun H, et al. Protective effects of ginsenoside Rg1 against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice through inhibiting toll-like receptor 4 signaling pathway. Int Immunopharmacol. 2018;61:266-276 pubmed publisher
Ya P, Xu H, Ma Y, Fang M, Yan X, Zhou J, et al. Liver injury induced in Balb/c mice by PM2.5 exposure and its alleviation by compound essential oils. Biomed Pharmacother. 2018;105:590-598 pubmed publisher
Xu R, Lin J, Zhao G, Li C, Che C, Xu Q, et al. Production of interleukin-1? related to mammalian target of rapamycin/Toll-like receptor 4 signaling pathway during Aspergillus fumigatus infection of the mouse cornea. Int J Ophthalmol. 2018;11:712-718 pubmed publisher
Liu F, Wen Y, Kang J, Wei C, Wang M, Zheng Z, et al. Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart. Int J Mol Med. 2018;42:1436-1444 pubmed publisher
Xue S, He W, Zeng X, Tang Z, Feng S, Zhong Z, et al. Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway. Mol Med Rep. 2018;18:815-826 pubmed publisher
Liu H, Ma S, Xia H, Lou H, Zhu F, Sun L. Anti-inflammatory activities and potential mechanisms of phenolic acids isolated from Salvia miltiorrhiza f. alba roots in THP-1 macrophages. J Ethnopharmacol. 2018;222:201-207 pubmed publisher
Lin L, Li R, Cai M, Huang J, Huang W, Guo Y, et al. Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-?B and TGF-?1/Smad2 Signaling Pathways. Oxid Med Cell Longev. 2018;2018:7808656 pubmed publisher
Wang Y, Chen H, Chen Q, Jiao F, Zhang W, Gong Z. The Protective Mechanism of CAY10683 on Intestinal Mucosal Barrier in Acute Liver Failure through LPS/TLR4/MyD88 Pathway. Mediators Inflamm. 2018;2018:7859601 pubmed publisher
Lai M, Yao H, Shah S, Wu W, Wang D, Zhao Y, et al. The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia. Front Aging Neurosci. 2018;10:116 pubmed publisher
Liu M, Li C, Zhao G, Lin J, Che C, Xu Q, et al. Boxb mediate BALB/c mice corneal inflammation through a TLR4/MyD88-dependent signaling pathway in Aspergillus fumigatus keratitis. Int J Ophthalmol. 2018;11:548-552 pubmed publisher
Chen G, Xu M, Chen J, Hong L, Lin W, Zhao S, et al. Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population. J Immunol Res. 2018;2018:7132868 pubmed publisher
Wang S, Yu T, Tsai F, Weston C, Lin M, Hung C, et al. Inhibition of semicarbazide-sensitive amine oxidase reduces atherosclerosis in apolipoprotein E-deficient mice. Transl Res. 2018;197:12-31 pubmed publisher
Ling C, Liang J, Zhang C, Li R, Mou Q, Qin J, et al. Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. Molecules. 2018;23: pubmed publisher
Cong L, Yang S, Zhang Y, Cao J, Fu X. DFMG attenuates the activation of macrophages induced by co?culture with LPC?injured HUVE?12 cells via the TLR4/MyD88/NF??B signaling pathway. Int J Mol Med. 2018;41:2619-2628 pubmed publisher
Sun M, Zhu Y, Zhou Z, Jia X, Xu Y, Yang Q, et al. Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway. Brain Behav Immun. 2018;70:48-60 pubmed publisher
Lian S, Wang D, Xu B, Guo W, Wang L, Li W, et al. Prenatal cold stress: Effect on maternal hippocampus and offspring behavior in rats. Behav Brain Res. 2018;346:1-10 pubmed publisher
Jia Y, Lu H, Peng Y, Zhang B, Gong X, Su J, et al. Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. Int Immunopharmacol. 2018;56:105-112 pubmed publisher
Liu X, Yin S, Chen Y, Wu Y, Zheng W, Dong H, et al. LPS?induced proinflammatory cytokine expression in human airway epithelial cells and macrophages via NF??B, STAT3 or AP?1 activation. Mol Med Rep. 2018;17:5484-5491 pubmed publisher
Hu C, Lu Y, Chen X, Wu Z, Zhang Q. Gene transfer of a naked plasmid (pUDK-HGF) encoding human hepatocyte growth factor attenuates skin/muscle incision and retraction-induced chronic post-surgical pain in rats. Eur J Pain. 2018;22:961-972 pubmed publisher
Sullivan A, Pangloli P, Dia V. Kafirin from Sorghum bicolor inhibition of inflammation in THP-1 human macrophages is associated with reduction of intracellular reactive oxygen species. Food Chem Toxicol. 2018;111:503-510 pubmed publisher
Liu C, Wang R, Yi Y, Gao Z, Chen Y. Lycopene mitigates β-amyloid induced inflammatory response and inhibits NF-κB signaling at the choroid plexus in early stages of Alzheimer's disease rats. J Nutr Biochem. 2018;53:66-71 pubmed publisher
Xu S, Qin B, Shi A, Zhao J, Guo X, Dong L. Oxytocin inhibited stress induced visceral hypersensitivity, enteric glial cells activation, and release of proinflammatory cytokines in maternal separated rats. Eur J Pharmacol. 2018;818:578-584 pubmed publisher
Guo X, Sinclair A, Kaur G, Li D. Differential effects of EPA, DPA and DHA on cardio-metabolic risk factors in high-fat diet fed mice. Prostaglandins Leukot Essent Fatty Acids. 2018;136:47-55 pubmed publisher
Zhang M, Hu X, Li S, Lu C, Li J, Zong Y, et al. Hepatoprotective effects of ethyl pyruvate against CCl4-induced hepatic fibrosis via inhibition of TLR4/NF-κB signaling and up-regulation of MMPs/TIMPs ratio. Clin Res Hepatol Gastroenterol. 2018;42:72-81 pubmed publisher
Zhang S, Wang Z, Zhu J, Xu T, Zhao Y, Zhao H, et al. Carnosic Acid Alleviates BDL-Induced Liver Fibrosis through miR-29b-3p-Mediated Inhibition of the High-Mobility Group Box 1/Toll-Like Receptor 4 Signaling Pathway in Rats. Front Pharmacol. 2017;8:976 pubmed publisher
Lian S, Guo J, Wang L, Li W, Wang J, Ji H, et al. Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats. Oncotarget. 2017;8:115304-115314 pubmed publisher
Cheng J, Yuan Z, Yang W, Xu C, Cong W, Lin L, et al. Comparative study of macrophages in naked mole rats and ICR mice. Oncotarget. 2017;8:96924-96934 pubmed publisher
Yang M, Lv Y, Tian X, Lou J, An R, Zhang Q, et al. Neuroprotective Effect of ?-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro. Front Neurosci. 2017;11:583 pubmed publisher
Zuo T, Zhu M, Xu W, Wang Z, Song H. Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome. Cell Physiol Biochem. 2017;43:1855-1865 pubmed publisher
Guo X, Gao J, Li J, Li D. fat-1 mice prevent high-fat plus high-sugar diet-induced non-alcoholic fatty liver disease. Food Funct. 2017;8:4053-4061 pubmed publisher
Yu M, Wang C, Zeng G, Zhou L, Chen T, Tan X, et al. Toll‑like receptor 4 is expressed and functional in late endothelial progenitor cells. Mol Med Rep. 2017;16:5549-5554 pubmed publisher
Li C, Yu Y, Li W, Liu B, Jiao X, Song X, et al. Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway. Sci Rep. 2017;7:5843 pubmed publisher
Yin Y, Li F, Li S, Cai J, Shi J, Jiang Y. TLR4 Influences Hepatitis B Virus Related Hepatocellular Carcinoma by Regulating the Wnt/β-Catenin Pathway. Cell Physiol Biochem. 2017;42:469-479 pubmed publisher
Zhou Q, Lin F, Liu S, Sui X. Influence of the total saponin fraction from Dioscorea nipponica Makino on TLR2/4-IL1R receptor singnal pathway in rats of gouty arthritis. J Ethnopharmacol. 2017;206:274-282 pubmed publisher
Wang H, Xu Y, Wang M, Cheng C, Bian R, Yuan H, et al. Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders. Int J Mol Med. 2017;39:819-830 pubmed publisher
Gu R, Lei B, Shu Q, Li G, Xu G. Glucocorticoid-induced leucine zipper overexpression inhibits lipopolysaccharide-induced retinal inflammation in rats. Exp Eye Res. 2017;165:151-163 pubmed publisher
Ma D, Zhang R, Wen Y, Yin W, Bai D, Zheng G, et al. 1, 25(OH)2D3-induced interaction of vitamin D receptor with p50 subunit of NF-?B suppresses the interaction between KLF5 and p50, contributing to inhibition of LPS-induced macrophage proliferation. Biochem Biophys Res Commun. 2017;482:366-374 pubmed publisher
Tao X, Sun X, Xu L, Yin L, Han X, Qi Y, et al. Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats. Nutrients. 2016;8: pubmed publisher
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, et al. Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation. Environ Toxicol Pharmacol. 2016;45:193-201 pubmed publisher
He K, Hu Y, Ma H, Zou Z, Xiao Y, Yang Y, et al. Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways. Biochim Biophys Acta. 2016;1862:1696-709 pubmed publisher
Wang Y, Chen G, Yu X, Li Y, Zhang L, He Z, et al. Salvianolic Acid B Ameliorates Cerebral Ischemia/Reperfusion Injury Through Inhibiting TLR4/MyD88 Signaling Pathway. Inflammation. 2016;39:1503-13 pubmed publisher
Xue L, Geng Y, Li M, Jin Y, Ren H, Li X, et al. The effects of D3R on TLR4 signaling involved in the regulation of METH-mediated mast cells activation. Int Immunopharmacol. 2016;36:187-198 pubmed publisher
Yao H, Hu C, Yin L, Tao X, Xu L, Qi Y, et al. Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway. Int Immunopharmacol. 2016;36:132-141 pubmed publisher
Wu J, Zhang H, Hu B, Yang L, Wang P, Wang F, et al. Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. Eur J Pharmacol. 2016;780:106-14 pubmed publisher
Jurga A, Rojewska E, Piotrowska A, Makuch W, Pilat D, Przewlocka B, et al. Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model. Neural Plast. 2016;2016:5238730 pubmed publisher
Dong D, Yin L, Qi Y, Xu L, Peng J. Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats. Nutrients. 2015;7:4829-50 pubmed publisher
product information
CatalogNo :
19811-1-AP
AntigenName :
TLR4
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
toll-like receptor 4
Immunogen :
Fusion Protein
Species :
calf, hamster, human, mouse, rat, swine
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IHC, IF, CoIP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
ARMD10, CD284, hToll, TLR4, TOLL, toll like receptor 4
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC117422
Category :
Binding Proteins;Development;Membrane Proteins;Neurology;Signal transduction;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IHC 1:200 ; WB 1:500 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.