This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
SIRT2-Specific
catalog :
19655-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 19
Reference
Zhang M, Du W, Acklin S, Jin S, Xia F. SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair. J Clin Invest. 2020;130:2953-2965 pubmed publisher
Wu Z, Zhang Y, Zhang Y, Zhao P. Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation. Cell Mol Neurobiol. 2019;: pubmed publisher
Sun X, Wang S, Li Q. Comprehensive Analysis of Expression and Prognostic Value of Sirtuins in Ovarian Cancer. Front Genet. 2019;10:879 pubmed publisher
Xu D, Jiang X, He H, Liu D, Yang L, Chen H, et al. SIRT2 functions in aging, autophagy, and apoptosis in post-maturation bovine oocytes. Life Sci. 2019;232:116639 pubmed publisher
Xu W, Yang R, Zheng H, Yu W, Zheng X, Li B, et al. PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy. Int J Biol Macromol. 2019;136:1007-1017 pubmed publisher
Zhang Y, Wan X, Wang H, Pan M, Pan Z, Sun S. RAB35 depletion affects spindle formation and actin-based spindle migration in mouse oocyte meiosis. Mol Hum Reprod. 2019;25:359-372 pubmed publisher
Liu J, Kang Y, Yin S, Chen A, Wu J, Liang H, et al. Key Role of Microtubule and Its Acetylation in a Zinc Oxide Nanoparticle-Mediated Lysosome-Autophagy System. Small. 2019;:e1901073 pubmed publisher
Xu D, Wu L, Jiang X, Yang L, Cheng J, Chen H, et al. SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation. Int J Mol Sci. 2019;20: pubmed publisher
Wang H, Zhang Y, Tang F, Pan M, Wan X, Li X, et al. Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics. Development. 2019;146: pubmed publisher
Kościuczuk E, Mehrotra S, Saleiro D, Kroczynska B, Majchrzak Kita B, Lisowski P, et al. Sirtuin 2-mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses. J Biol Chem. 2019;294:827-837 pubmed publisher
Lantier L, Williams A, Hughey C, Bracy D, James F, Ansari M, et al. SIRT2 knockout exacerbates insulin resistance in high fat-fed mice. PLoS ONE. 2018;13:e0208634 pubmed publisher
Tang F, Pan M, Wan X, Lu Y, Zhang Y, Sun S. Kif18a regulates Sirt2-mediated tubulin acetylation for spindle organization during mouse oocyte meiosis. Cell Div. 2018;13:9 pubmed publisher
Song R, Yang Y, Lei H, Wang G, Huang Y, Xue W, et al. HDAC6 inhibition protects cardiomyocytes against doxorubicin-induced acute damage by improving α-tubulin acetylation. J Mol Cell Cardiol. 2018;124:58-69 pubmed publisher
Kang H, Song H, Ahmed M, Guo Y, Zhang M, Chen C, et al. NQO1 regulates mitotic progression and response to mitotic stress through modulating SIRT2 activity. Free Radic Biol Med. 2018;126:358-371 pubmed publisher
Zhang T, Wang P, Liu Y, Zhou J, Shi Z, Cheng K, et al. Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo. Cell Tissue Res. 2018;373:379-393 pubmed publisher
Liu M, Liang K, Zhen J, Zhou M, Wang X, Wang Z, et al. Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling. Nat Commun. 2017;8:413 pubmed publisher
Wu J, He Z, Yang X, Li K, Wang D, Sun F. RCCD1 depletion attenuates TGF-β-induced EMT and cell migration by stabilizing cytoskeletal microtubules in NSCLC cells. Cancer Lett. 2017;400:18-29 pubmed publisher
Xie X, Zhang P, Tian B, Chen X. Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke. Mol Neurobiol. 2017;54:7251-7261 pubmed publisher
Liu G, Park S, Imbesi M, Nathan W, Zou X, Zhu Y, et al. Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy. Antioxid Redox Signal. 2017;26:849-863 pubmed publisher
product information
CatalogNo :
19655-1-AP
AntigenName :
SIRT2-Specific
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
Immunogen :
Fusion Protein
Species :
bovine, human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, CoIP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
SIR2, SIR2 like protein 2, SIR2L, SIR2L2, SIRT2
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC003547
Category :
Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IHC 1:50 ; IP 1:800 ; WB 1:600 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.