This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
CDK1-Specific
catalog :
19532-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, western blot knockout validation
citations: 65
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:1000; loading ...; fig s3
Sang Y, Li Y, Zhang Y, Alvarez A, Yu B, Zhang W, et al. CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity. Nat Commun. 2019;10:4013 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig s4d
Peng J, Sun B, Chen C, Zhou J, Chen Y, Chen H, et al. Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma. Cell Res. 2019;29:725-738 pubmed publisher
  • western blot; human; fig 5
Zhang M, Linghu E, Zhan Q, He T, Cao B, Brock M, et al. Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling. Oncotarget. 2016;7:17957-69 pubmed publisher
Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J. Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways. Nutr Cancer. 2020;:1-12 pubmed publisher
Dong X, Kong F, Liu C, Dai S, Zhang Y, Xiao F, et al. Pulp stem cells with hepatocyte growth factor overexpression exhibit dual effects in rheumatoid arthritis. Stem Cell Res Ther. 2020;11:229 pubmed publisher
Shi J, Lv S, Wu M, Wang X, Deng Y, Li Y, et al. HOTAIR-EZH2 inhibitor AC1Q3QWB upregulates CWF19L1 and enhances cell cycle inhibition of CDK4/6 inhibitor palbociclib in glioma. Clin Transl Med. 2020;10:182-198 pubmed publisher
Liu J, Fu W, Zheng X, Li W, Ren L, Wang J, et al. Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest. Acta Pharmacol Sin. 2020;: pubmed publisher
Li H, Pan R, Lu Q, Ren C, Sun J, Wu H, et al. MicroRNA‑145‑5p inhibits osteosarcoma cell proliferation by targeting E2F transcription factor 3. Int J Mol Med. 2020;45:1317-1326 pubmed publisher
Li L, Huang K, Zhao H, Chen B, Ye Q, Yue J. CDK1-PLK1/SGOL2/ANLN pathway mediating abnormal cell division in cell cycle may be a critical process in hepatocellular carcinoma. Cell Cycle. 2020;19:1236-1252 pubmed publisher
Shi L, Duan Y, Yao X, Song R, Ren Y. Effects of selenium on the proliferation and apoptosis of sheep spermatogonial stem cells in vitro. Anim Reprod Sci. 2020;215:106330 pubmed publisher
Fu F, Zhang Y, Gao Z, Zhao Y, Wen Z, Han H, et al. Development and validation of a five-gene model to predict postoperative brain metastasis in operable lung adenocarcinoma. Int J Cancer. 2020;147:584-592 pubmed publisher
Du S, Wang H, Cai J, Ren R, Zhang W, Wei W, et al. Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc-p21Waf1 signalling pathway. Biochem Cell Biol. 2020;98:191-202 pubmed publisher
Guo J, Zhang J, Liang L, Liu N, Qi M, Zhao S, et al. Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin. J Cell Mol Med. 2020;24:4324-4340 pubmed publisher
Liu H, Liao W, Fan L, Zheng Z, Liu D, Zhang Q, et al. Ethanol extract of Ophiorrhiza pumila suppresses liver cancer cell proliferation and migration. Chin Med. 2020;15:11 pubmed publisher
Shang Y, Wang Q, Li J, Zhao Q, Huang X, Dong H, et al. The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis. Onco Targets Ther. 2020;13:473-486 pubmed publisher
Gao X, Zhang Y, Zhang R, Zhao Z, Zhang H, Wu J, et al. Cyclin-dependent kinase 1 disruption inhibits angiogenesis by inducing cell cycle arrest and apoptosis. Exp Ther Med. 2019;18:3062-3070 pubmed publisher
Liu B, Liu Y, Wang Y, Xie C, Gan M, Han T, et al. CyclinB1 deubiquitination by USP14 regulates cell cycle progression in breast cancer. Pathol Res Pract. 2019;215:152592 pubmed publisher
Cheng Z, Xin H, Han T. BECN1 promotes the migration of NSCLC cells through regulating the ubiquitination of Vimentin. Cell Adh Migr. 2019;13:249-259 pubmed publisher
Zhang W, He P, Wang S, Adili A, Chen Z, Zhang C, et al. Characterization of Protein Profiling and mRNA Expression of LLC Exosomes. Protein J. 2019;: pubmed publisher
Yuan Z, Chen P, Zhang T, Shen B, Chen L. Agenesis and Hypomyelination of Corpus Callosum in Mice Lacking Nsun5, an RNA Methyltransferase. Cells. 2019;8: pubmed publisher
Guo D, Wang Y, Wang J, Song L, Wang Z, Mao B, et al. RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression. Molecules. 2019;24: pubmed publisher
Wang Y, Han T, Gan M, Guo M, Xie C, Jin J, et al. A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer. Cell Cycle. 2019;18:1019-1032 pubmed publisher
Qi W, Xu X, Wang M, Li X, Wang C, Sun L, et al. Inhibition of Wee1 sensitizes AML cells to ATR inhibitor VE-822-induced DNA damage and apoptosis. Biochem Pharmacol. 2019;164:273-282 pubmed publisher
Li N, Piao J, Wang X, Kim K, Bae J, Ren X, et al. Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis. Cancer Res Treat. 2019;: pubmed publisher
Lin X, Xiaoqin H, Jiayu C, Li F, Yue L, Ximing X. Long non-coding RNA miR143HG predicts good prognosis and inhibits tumor multiplication and metastasis by suppressing mitogen-activated protein kinase and Wnt signaling pathways in hepatocellular carcinoma. Hepatol Res. 2019;: pubmed publisher
Piao J, Zhu L, Sun J, Li N, Dong B, Yang Y, et al. High expression of CDK1 and BUB1 predicts poor prognosis of pancreatic ductal adenocarcinoma. Gene. 2019;701:15-22 pubmed publisher
Qin H, Li Y, Zhang H, Wang F, He H, Bai X, et al. Prognostic implications and oncogenic roles of MYBL2 protein expression in esophageal squamous-cell carcinoma. Onco Targets Ther. 2019;12:1917-1927 pubmed publisher
Wang Y, Lv Y, Liu T, Yan W, Chen L, Li Z, et al. Cordycepin suppresses cell proliferation and migration by targeting CLEC2 in human gastric cancer cells via Akt signaling pathway. Life Sci. 2019;223:110-119 pubmed publisher
Liu Y, Dong N, Miao J, Li C, Wang X, Ruan J. Lin28 promotes dental pulp cell proliferation via upregulation of cyclin-dependent proteins and interaction with let-7a/IGF2BP2 pathways. Biomed Pharmacother. 2019;113:108742 pubmed publisher
Yun D, Wang H, Wang Y, Chen Y, Zhao Z, Ma J, et al. Shuttling SLC2A4RG is regulated by 14-3-3θ to modulate cell survival via caspase-3 and caspase-6 in human glioma. EBioMedicine. 2019;40:163-175 pubmed publisher
Li Y, Quan J, Chen F, Pan X, Zhuang C, Xiong T, et al. MiR-31-5p acts as a tumor suppressor in renal cell carcinoma by targeting cyclin-dependent kinase 1 (CDK1). Biomed Pharmacother. 2019;111:517-526 pubmed publisher
Jia J, Li C, Yang J, Wang X, Li R, Luo S, et al. Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway. Sci Rep. 2018;8:14513 pubmed publisher
Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N, et al. Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells. Mol Pharm. 2018;15:4974-4984 pubmed publisher
Luo Y, Mohsin A, Xu C, Wang Q, Hang H, Zhuang Y, et al. Co-culture with TM4 cells enhances the proliferation and migration of rat adipose-derived mesenchymal stem cells with high stemness. Cytotechnology. 2018;70:1409-1422 pubmed publisher
Li W, Liu J, Fu W, Zheng X, Ren L, Liu S, et al. 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase. J Exp Clin Cancer Res. 2018;37:132 pubmed publisher
Song H, Guo T, Zhao Z, Wei Y, Luo H, Weng W, et al. Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis. Biomaterials. 2018;178:23-35 pubmed publisher
Liu Y, Wang L, Chen S, Zong Z, Guan X, Zhao Y. LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1. J Cell Mol Med. 2018;: pubmed publisher
Guo T, Song H, Zhao Z, Qi Z, Zhao S. Overexpression of Annexin A2 Receptor Inhibits Neovascularization via the Promotion of Krüppel-Like Transcription Factor 2. Cell Physiol Biochem. 2018;46:1617-1627 pubmed publisher
He J, Zhao Y, Zhao E, Wang X, Dong Z, Chen Y, et al. Cancer-testis specific gene OIP5: a downstream gene of E2F1 that promotes tumorigenesis and metastasis in glioblastoma by stabilizing E2F1 signaling. Neuro Oncol. 2018;20:1173-1184 pubmed publisher
Liu D, Cheng Y, Cai R, Wang Bd W, Cui H, Liu M, et al. The enhancement of siPLK1 penetration across BBB and its anti glioblastoma activity in vivo by magnet and transferrin co-modified nanoparticle. Nanomedicine. 2018;14:991-1003 pubmed publisher
Wang L, Yang H, Hu L, Hu D, Ma S, Sun X, et al. CDKN1C (P57): one of the determinants of human endometrial stromal cell decidualization. Biol Reprod. 2018;98:277-285 pubmed publisher
He J, Chen Y, Cai L, Li Z, Guo X. UBAP2L silencing inhibits cell proliferation and G2/M phase transition in breast cancer. Breast Cancer. 2018;25:224-232 pubmed publisher
Zhang X, Chen W, Li J, Qi S, Hong S, Wang Y, et al. Involvement of mitochondrial fission in calcium sensing receptor-mediated vascular smooth muscle cells proliferation during hypertension. Biochem Biophys Res Commun. 2018;495:454-460 pubmed publisher
Zhao J, Zhu J, Lv X, Xing J, Liu S, Chen C, et al. Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-?B/COX-2 signaling pathways. Onco Targets Ther. 2017;10:5471-5482 pubmed publisher
Guo Y, Peng Y, Gao D, Zhang M, Yang W, Linghu E, et al. Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma. Clin Epigenetics. 2017;9:116 pubmed publisher
Li X, Jiang Z, Feng J, Zhang X, Wu J, Chen W. 2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G2/M cell cycle arrest through generation of thiol oxidative stress in human esophageal cancer. Oncotarget. 2017;8:61846-61860 pubmed publisher
Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J, et al. Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain. J Agric Food Chem. 2017;65:5973-5984 pubmed publisher
Wang L, Sun K, Wu D, Xiu Y, Chen X, Chen S, et al. DLEU1 contributes to ovarian carcinoma tumourigenesis and development by interacting with miR-490-3p and altering CDK1 expression. J Cell Mol Med. 2017;21:3055-3065 pubmed publisher
Wang L, Xiu Y, Chen X, Sun K, Chen S, Wu D, et al. The transcription factor FOXA1 induces epithelial ovarian cancer tumorigenesis and progression. Tumour Biol. 2017;39:1010428317706210 pubmed publisher
Xu B, Ye M, Lv S, Wang Q, Wu M, Xiao B, et al. SNORD47, a box C/D snoRNA, suppresses tumorigenesis in glioblastoma. Oncotarget. 2017;8:43953-43966 pubmed publisher
Gan Z, Han K, Lin S, Hu H, Shen Z, Min D. Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro. Biol Res. 2017;50:15 pubmed publisher
Teng B, Jiang J, Zhao L, Gao J, Chen J, Liu Z, et al. Ginsenoside PPD's Antitumor Effect via Down-Regulation of mTOR Revealed by Super-Resolution Imaging. Molecules. 2017;22: pubmed publisher
Lin Z, Liu J, Jiang G, Tan G, Gong P, Luo H, et al. Osthole inhibits the tumorigenesis of hepatocellular carcinoma cells. Oncol Rep. 2017;37:1611-1618 pubmed publisher
Zhou Y, Wang K, Zhen S, Wang R, Luo W. Carfilzomib induces G2/M cell cycle arrest in human endometrial cancer cells via upregulation of p21Waf1/Cip1 and p27Kip1. Taiwan J Obstet Gynecol. 2016;55:847-851 pubmed publisher
Yang J, Qiao L, Zeng Z, Wang J, Zhu T, Wei J, et al. The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD. Toxicol Lett. 2017;265:131-139 pubmed publisher
Jiang G, Liu J, Ren B, Tang Y, Owusu L, Li M, et al. Anti-tumor effects of osthole on ovarian cancer cells in vitro. J Ethnopharmacol. 2016;193:368-376 pubmed publisher
Huo Y, Zheng Z, Chen Y, Wang Q, Zhang Z, Deng H. Downregulation of vimentin expression increased drug resistance in ovarian cancer cells. Oncotarget. 2016;7:45876-45888 pubmed publisher
Chen S, Sun K, Feng M, Sang X, Liu B, Zhao Y. Role of glycogen synthase kinase-3? inhibitor AZD1080 in ovarian cancer. Drug Des Devel Ther. 2016;10:1225-32 pubmed publisher
Pan X, Chen L, Hong Y, Xu D, Liu X, Li L, et al. EIF3D silencing suppresses renal cell carcinoma tumorigenesis via inducing G2/M arrest through downregulation of Cyclin B1/CDK1 signaling. Int J Oncol. 2016;48:2580-90 pubmed publisher
Jia J, Li C, Luo S, Liu Smith F, Yang J, Wang X, et al. Yes-Associated Protein Contributes to the Development of Human Cutaneous Squamous Cell Carcinoma via Activation of RAS. J Invest Dermatol. 2016;136:1267-1277 pubmed publisher
Junyan P, Shujuan Y, Shulin G, Yan C, Xia X. The Antitumor Effect of DYC-279 on Human Hepatocellular Carcinoma HepG2 Cells. Pharmacology. 2016;97:177-83 pubmed publisher
Zhan W, Han T, Zhang C, Xie C, Gan M, Deng K, et al. TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins. PLoS ONE. 2015;10:e0142596 pubmed publisher
Ching R, Lau E, Ling P, Lee J, Ma M, Cheng B, et al. Phosphorylation of nucleophosmin at threonine 234/237 is associated with HCC metastasis. Oncotarget. 2015;6:43483-95 pubmed publisher
He Y, Cao X, Liu X, Li X, Xu Y, Liu J, et al. Quercetin reverses experimental pulmonary arterial hypertension by modulating the TrkA pathway. Exp Cell Res. 2015;339:122-34 pubmed publisher
Wang Z, Xu D, Gao Y, Liu Y, Ren J, Yao Y, et al. Immature Colon Carcinoma Transcript 1 Is Essential for Prostate Cancer Cell Viability and Proliferation. Cancer Biother Radiopharm. 2015;30:278-84 pubmed publisher
product information
CatalogNo :
19532-1-AP
AntigenName :
CDK1-Specific
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
cell division cycle 2, G1 to S and G2 to M
Immunogen :
Peptide
Species :
human, mouse, rat, sheep
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IHC, IF, CoIP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
CDC2, CDC28A, CDK1, Cell division protein kinase 1, Cyclin dependent kinase 1, p34 protein kinase
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
NM_001786
Category :
Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;Metabolism;Neurology;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:200 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.