This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
CHCHD2
catalog :
19424-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 14
Reference
Liu Y, Huang X, Nguyen D, Shammas M, Wu B, Dombi E, et al. Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations. Hum Mol Genet. 2020;29:1547-1567 pubmed publisher
Erickson R, Aras S, Purandare N, Huttemann M, Liu J, Dragotto J, et al. Decreased membrane cholesterol in liver mitochondria of the point mutation mouse model of juvenile Niemann-Pick C1, Npc1nmf164. Mitochondrion. 2020;51:15-21 pubmed publisher
Aras S, Maroun M, Song Y, Bandyopadhyay S, Stark A, Yang Z, et al. Mitochondrial autoimmunity and MNRR1 in breast carcinogenesis. BMC Cancer. 2019;19:411 pubmed publisher
Papadopoulos N, Lennartsson J, Heldin C. PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1. J Cell Biol. 2018;217:1701-1717 pubmed publisher
Purandare N, Somayajulu M, Huttemann M, Grossman L, Aras S. The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction. J Biol Chem. 2018;293:6517-6529 pubmed publisher
Burstein S, Valsecchi F, Kawamata H, Bourens M, Zeng R, Zuberi A, et al. In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions. Hum Mol Genet. 2018;27:160-177 pubmed publisher
Meng H, Yamashita C, Shiba Fukushima K, Inoshita T, Funayama M, Sato S, et al. Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c. Nat Commun. 2017;8:15500 pubmed publisher
Xin Q, Deng C, Chen X, Wang J, Wang S, Wang W, et al. Quantitative Proteomic Analysis of Mosquito C6/36 Cells Reveals Host Proteins Involved in Zika Virus Infection. J Virol. 2017;91: pubmed publisher
Xu X, Tay Y, Sim B, Yoon S, Huang Y, Ooi J, et al. Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells. Stem Cell Reports. 2017;8:619-633 pubmed publisher
Aras S, Arrabi H, Purandare N, Huttemann M, Kamholz J, Zuchner S, et al. Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration. Biochim Biophys Acta Mol Cell Res. 2017;1864:440-448 pubmed publisher
Ogaki K, Koga S, Heckman M, Fiesel F, Ando M, Labbé C, et al. Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders. Neurology. 2015;85:2016-25 pubmed publisher
Li H, Zhang L, Zhu X, Shang J, Chen X, Zhu Y, et al. Analysis of EV71 infection progression using triple-SILAC-based proteomics approach. Proteomics. 2015;15:3629-43 pubmed publisher
Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, et al. CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study. Lancet Neurol. 2015;14:274-82 pubmed publisher
Aras S, Bai M, Lee I, Springett R, Hüttemann M, Grossman L. MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism. Mitochondrion. 2015;20:43-51 pubmed publisher
product information
CatalogNo :
19424-1-AP
AntigenName :
CHCHD2
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
coiled-coil-helix-coiled-coil-helix domain containing 2
Immunogen :
Fusion Protein
Species :
drosophila, human, mouse
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, CoIP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
C7orf17, CHCHD2, MNRR1, NS2TP
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC003079
Category :
Cytoskeleton/Scaffold Proteins;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:200 ; IP 1:1000 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.