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product summary
company name :
Proteintech Group
product type :
antibody
product name :
P62/SQSTM1
catalog :
18420-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 378
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 5b
Xiang S, Chen K, Xu L, Wang T, Guo C. Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway. Drug Des Devel Ther. 2020;14:129-143 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2e
Zhou Q, Zhu L, Qiu W, Liu Y, Yang F, Chen W, et al. Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1G93A Mice. Int J Biol Sci. 2020;16:284-297 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 5e
Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019;10:5681 pubmed publisher
  • western blot; human; loading ...; fig 5a
  • western blot; mouse; loading ...; fig 4b
Zhang Y, Cao Y, Chen J, Qin H, Yang L. A New Possible Mechanism by Which Punicalagin Protects against Liver Injury Induced by Type 2 Diabetes Mellitus: Upregulation of Autophagy via the Akt/FoxO3a Signaling Pathway. J Agric Food Chem. 2019;: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2b
Xu Y, Wang Y, Yao A, Xu Z, Dou H, Shen S, et al. Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway. Sci Rep. 2017;7:11776 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s6c
Lee C, Hanna A, Wang H, Dagnino Acosta A, Joshi A, Knoblauch M, et al. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017;8:14659 pubmed publisher
  • western blot; human; 1:1000; fig 5
Huang Q, Zhan L, Cao H, Li J, Lyu Y, Guo X, et al. Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways. Autophagy. 2016;12:999-1014 pubmed publisher
Zou Y, Xu J, Wang X, Zhu Y, Wu Q, Wang J. Lactobacillus johnsonii L531 Ameliorates Escherichia coli-Induced Cell Damage via Inhibiting NLRP3 Inflammasome Activity and Promoting ATG5/ATG16L1-Mediated Autophagy in Porcine Mammary Epithelial Cells. Vet Sci. 2020;7: pubmed publisher
Yu X, Fan H, Jiang X, Zheng W, Yang Y, Jin M, et al. Apatinib induces apoptosis and autophagy via the PI3K/AKT/mTOR and MAPK/ERK signaling pathways in neuroblastoma. Oncol Lett. 2020;20:52 pubmed publisher
Zhang Y, Zhang M, Zhao X, Shi K, Ye M, Tian J, et al. NAD+ administration decreases microvascular damage following cardiac ischemia/reperfusion by restoring autophagic flux. Basic Res Cardiol. 2020;115:57 pubmed publisher
Sun Y, He L, Wang T, Hua W, Qin H, Wang J, et al. Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells. Mol Neurobiol. 2020;: pubmed publisher
Yang F, Qu Q, Zhao C, Liu X, Yang P, Li Z, et al. Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice. Biomed Pharmacother. 2020;129:110479 pubmed publisher
Xu X, Chen B, Huang Q, Wu Y, Liang T. The Effects of Puerarin on Autophagy Through Regulating of the PERK/eIF2α/ATF4 Signaling Pathway Influences Renal Function in Diabetic Nephropathy. Diabetes Metab Syndr Obes. 2020;13:2583-2592 pubmed publisher
Chu B, Zhu Y, Su J, Xia B, Zou Y, Nie J, et al. Butyrate-mediated autophagy inhibition limits cytosolic Salmonella Infantis replication in the colon of pigs treated with a mixture of Lactobacillus and Bacillus. Vet Res. 2020;51:99 pubmed publisher
Shao C, Zhou X, Zheng X, Huang Q. Ganoderic acid D induces synergistic autophagic cell death except for apoptosis in ESCC cells. J Ethnopharmacol. 2020;262:113213 pubmed publisher
Li Z, Cheng J, Liu J. Baicalin Protects Human OA Chondrocytes Against IL-1β-Induced Apoptosis and ECM Degradation by Activating Autophagy via MiR-766-3p/AIFM1 Axis. Drug Des Devel Ther. 2020;14:2645-2655 pubmed publisher
Mou J, Xu J, Wang Z, Wang C, Yang X, Wang X, et al. Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis. J Cell Physiol. 2020;: pubmed publisher
Zhang Z, Han K, Wang C, Sun C, Jia N. Dioscin Protects against Aβ1-42 Oligomers-Induced Neurotoxicity via the Function of SIRT3 and Autophagy. Chem Pharm Bull (Tokyo). 2020;68:717-725 pubmed publisher
Zhou C, Yi C, Yi Y, Qin W, Yan Y, Dong X, et al. LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes. Mol Cancer. 2020;19:118 pubmed publisher
Liu Z, Ye S, Zhong X, Wang W, Lai C, Yang W, et al. Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy. Mol Med Rep. 2020;22:2373-2385 pubmed publisher
Lu J, Lu J, Chen Y, Feng Z, Liu S, Guan S. 3-Chloro-1, 2-propanediol inhibits autophagic flux by impairment of lysosomal function in HepG2 cells. Food Chem Toxicol. 2020;144:111575 pubmed publisher
Chen Y, Navarrete M, Wang Y, McClintock N, Sakurai R, Wang F, et al. N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells. Sci Rep. 2020;10:11952 pubmed publisher
Qu W, Tarique I, Deng B, Zhang Y, Haseeb A, Chen Q, et al. Cellular evidence of autophagy in Sertoli cells during spermatogenesis in goats. Theriogenology. 2020;154:237-245 pubmed publisher
Pang C, Song C, Li Y, Wang Q, Zhu X, Wu J, et al. The Establishment and Application Studies on Precise Lysosome pH Indicator Based on Self-Decomposable Nanoparticles. Nanoscale Res Lett. 2020;15:143 pubmed publisher
Zhao Y, Tang J, Yang D, Tang C, Chen J. Staphylococcal enterotoxin M induced inflammation and impairment of bovine mammary epithelial cells. J Dairy Sci. 2020;103:8350-8359 pubmed publisher
Mei Z, Huang Y, Feng Z, Luo Y, Yang S, DU L, et al. Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway. Aging (Albany NY). 2020;12:13187-13205 pubmed publisher
Yuan M, Yang X, Duscher D, Xiong H, Ren S, Xu X, et al. Overexpression of microRNA-21-5p prevents the oxidative stress-induced apoptosis of RSC96 cells by suppressing autophagy. Life Sci. 2020;256:118022 pubmed publisher
Liu J, Hu Y, Feng Y, Jiang Y, Guo Y, Liu Y, et al. BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer. J Exp Clin Cancer Res. 2020;39:123 pubmed publisher
Hao Y, Huang Y, Chen J, Li J, Yuan Y, Wang M, et al. Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling. Cell Prolif. 2020;53:e12869 pubmed publisher
Wang L, Xu X, Liu T, Wang J, Shen J, Guo M, et al. 1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42), a novel ALK inhibitor, induces apoptosis and protective autophagy in H2228 cells. J Pharm Pharmacol. 2020;72:1370-1382 pubmed publisher
Hao J, Song Y, Tian B, Qi C, Li L, Wang L, et al. Platycodon grandifloras polysaccharides inhibit mitophagy injury induced by Cr (VI) in DF-1 cells. Ecotoxicol Environ Saf. 2020;202:110901 pubmed publisher
Zhou F, Xiong X, Li S, Liang J, Zhang X, Tian M, et al. Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice. Aging (Albany NY). 2020;12:12142-12159 pubmed publisher
Liu X, Mi X, Wang Z, Zhang M, Hou J, Jiang S, et al. Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway. Cell Death Dis. 2020;11:454 pubmed publisher
Li Y, Wu J, Yu S, Zhu J, Zhou Y, Wang P, et al. Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats. Brain Res. 2020;1745:146948 pubmed publisher
Fu N, Du H, Li D, Lu Y, Li W, Wang Y, et al. Clusterin contributes to hepatitis C virus-related hepatocellular carcinoma by regulating autophagy. Life Sci. 2020;256:117911 pubmed publisher
Nordgren K, Wallace K. Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo. Cardiovasc Toxicol. 2020;: pubmed publisher
Ma W, Liang F, Zhan H, Jiang X, Gao C, Zhang X, et al. Activated FMS-like tyrosine kinase 3 ameliorates angiotensin II-induced cardiac remodelling. Acta Physiol (Oxf). 2020;230:e13519 pubmed publisher
Wang M, Zhang M, Feng Y, Xing Y, Tan Z, Li W, et al. Electroacupuncture Inhibits Neuronal Autophagy and Apoptosis via the PI3K/AKT Pathway Following Ischemic Stroke. Front Cell Neurosci. 2020;14:134 pubmed publisher
Liu Y, Wang Y, Liu J, Kang R, Tang D. Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death. Cancer Gene Ther. 2020;: pubmed publisher
Wang Y, Wang X, Wang L, Cheng G, Zhang M, Xing Y, et al. Mitophagy Induced by Mitochondrial Function Damage in Chicken Kidney Exposed to Cr(VI). Biol Trace Elem Res. 2020;: pubmed publisher
Wang Z, Xu J, Mou J, Kong X, Wu M, Xue H, et al. Photoperiod Affects Harderian Gland Morphology and Secretion in Female Cricetulus barabensis: Autophagy, Apoptosis, and Mitochondria. Front Physiol. 2020;11:408 pubmed publisher
You L, Chen J, Liu W, Xiang Q, Luo Z, Wang W, et al. Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation. Virulence. 2020;11:537-553 pubmed publisher
Chen T, Zhang W, Huang B, Chen X, Huang C. UBQLN2 Promotes the Production of Type I Interferon via the TBK1-IRF3 Pathway. Cells. 2020;9: pubmed publisher
Ma J, Qi J, Li S, Zhang C, Wang H, Shao L, et al. Desloratadine, a Novel Antigrowth Reagent for Bladder Cancer. Technol Cancer Res Treat. 2020;19:1533033820926591 pubmed publisher
Fischer K, Fenzl A, Liu D, Dyar K, Kleinert M, Brielmeier M, et al. The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation. Nat Commun. 2020;11:2306 pubmed publisher
Feng J, Zhang Y, Ren X, Li D, Fu H, Liu C, et al. Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide. Oncogene. 2020;39:4551-4566 pubmed publisher
Tian Y, Guo H, Miao X, Xu J, Yang R, Zhao L, et al. Nestin protects podocyte from injury in lupus nephritis by mitophagy and oxidative stress. Cell Death Dis. 2020;11:319 pubmed publisher
Lin D, Ho C, Huang Y, Wu T, Lee T, Huang Z, et al. Impairment of Proteasome and Autophagy Underlying the Pathogenesis of Leukodystrophy. Cells. 2020;9: pubmed publisher
Chen H, Liang F, Gu P, Xu B, Xu H, Wang W, et al. Exosomes derived from mesenchymal stem cells repair a Parkinson's disease model by inducing autophagy. Cell Death Dis. 2020;11:288 pubmed publisher
Xie X, Chen C, Xu C, Lin J, Cao L, Chen G, et al. The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ETA Receptor in Mouse Mesenteric Arteries. Adv Pharmacol Pharm Sci. 2020;2020:5070436 pubmed publisher
Zhao X, Shi Y, Zhang D, Tong X, Sun Y, Xue X, et al. Autophagy inducer activates Nrf2-ARE pathway to attenuate aberrant alveolarization in neonatal rats with bronchopulmonary dysplasia. Life Sci. 2020;252:117662 pubmed publisher
Shen Q, Shi Y, Liu J, Su H, Huang J, Zhang Y, et al. Acetylation of STX17 (syntaxin 17) controls autophagosome maturation. Autophagy. 2020;:1-13 pubmed publisher
Chen Z, Liu L, Liu Y, Wang S, Zhang S, Dong R, et al. Hydroxysafflor yellow A induces autophagy in human liver cancer cells by regulating Beclin 1 and ERK expression. Exp Ther Med. 2020;19:2989-2996 pubmed publisher
Zhou H, Xu C, Lee H, Yoon Y, Chen W. Berardinelli-Seip congenital lipodystrophy 2/SEIPIN determines brown adipose tissue maintenance and thermogenic programing. Mol Metab. 2020;36:100971 pubmed publisher
Luo S, Shao L, Chen Z, Hu D, Jiang L, Tang W. NPRL2 promotes docetaxel chemoresistance in castration resistant prostate cancer cells by regulating autophagy through the mTOR pathway. Exp Cell Res. 2020;390:111981 pubmed publisher
Xu S, Mao Y, Wu J, Feng J, Li J, Wu L, et al. TGF-β/Smad and JAK/STAT pathways are involved in the anti-fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis. J Cell Mol Med. 2020;24:5224-5237 pubmed publisher
Deng X, Liu J, Liu L, Sun X, Huang J, Dong J. Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway. Int J Biol Sci. 2020;16:1403-1416 pubmed publisher
Ma R, Zhang B, Zhang Z, Deng Q. LncRNA MALAT1 knockdown inhibits cell migration and invasion by suppressing autophagy through miR-384/GOLM1 axis in glioma. Eur Rev Med Pharmacol Sci. 2020;24:2601-2615 pubmed publisher
Feng X, Zhang H, Meng L, Song H, Zhou Q, Qu C, et al. Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5. Autophagy. 2020;:1-20 pubmed publisher
Choi I, Zhang Y, Seegobin S, Pruvost M, Wang Q, Purtell K, et al. Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration. Nat Commun. 2020;11:1386 pubmed publisher
Shi W, Ma H, Liu T, Yan D, Luo P, Zhai M, et al. Inhibition of Interleukin-6/glycoprotein 130 signalling by Bazedoxifene ameliorates cardiac remodelling in pressure overload mice. J Cell Mol Med. 2020;24:4748-4761 pubmed publisher
Yu M, Yang J, Gao X, Sun W, Liu S, Han Y, et al. Lanthanum chloride impairs spatial learning and memory by inducing [Ca2+]m overload, mitochondrial fission-fusion disorder and excessive mitophagy in hippocampal nerve cells of rats. Metallomics. 2020;12:592-606 pubmed publisher
Sun X, Wang D, Zhang T, Lu X, Duan F, Ju L, et al. Eugenol Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Autophagy via AMPK-mTOR-P70S6K Pathway. Front Pharmacol. 2020;11:84 pubmed publisher
Zhang Y, Zhang Z, Li N, Zhao L, Xue Y, Wu H, et al. Nbr1-regulated autophagy in Lactoferrin-induced osteoblastic differentiation. Biosci Biotechnol Biochem. 2020;84:1191-1200 pubmed publisher
Yu Y, Cai L, Wang X, Cheng S, Zhang D, Jian W, et al. BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma. Cancer Sci. 2020;111:1555-1566 pubmed publisher
Lyu Z, Cao X, Wen Q, Mo X, Zhao H, Chen Y, et al. Autophagy in endothelial cells regulates their haematopoiesis-supporting ability. EBioMedicine. 2020;53:102677 pubmed publisher
Zeng Y, Guo Z, Hu Z, Liu M, Chen Y, Chen S, et al. FGD1 exhibits oncogenic properties in hepatocellular carcinoma through regulating cell morphology, autophagy and mitochondrial function. Biomed Pharmacother. 2020;125:110029 pubmed publisher
Xie W, Jin S, Wu Y, Xian H, Tian S, Liu D, et al. Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34. Cell Rep. 2020;30:2807-2819.e4 pubmed publisher
You G, Long X, Song F, Huang J, Tian M, Xiao Y, et al. Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis. Drug Des Devel Ther. 2020;14:457-468 pubmed publisher
Wang N, Xu F, Lu S, Zhang N, Sun Y. Septin4 as an autophagy modulator regulates Angiotensin-II mediated VSMCs proliferation and migration. Biochem Biophys Res Commun. 2020;525:272-279 pubmed publisher
Zheng Y, Zhu G, Tang Y, Yan J, Han S, Yin J, et al. HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection. Front Microbiol. 2020;11:78 pubmed publisher
Liang C, Feng Z, Manthari R, Wang C, Han Y, Fu W, et al. Arsenic induces dysfunctional autophagy via dual regulation of mTOR pathway and Beclin1-Vps34/PI3K complex in MLTC-1 cells. J Hazard Mater. 2020;391:122227 pubmed publisher
Li G, Song Y, Liao Z, Wang K, Luo R, Lu S, et al. Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy. Cell Death Dis. 2020;11:103 pubmed publisher
Yan K, Wu C, Ye Y, Li L, Wang X, He W, et al. A20 inhibits osteoclastogenesis via TRAF6-dependent autophagy in human periodontal ligament cells under hypoxia. Cell Prolif. 2020;53:e12778 pubmed publisher
Cai Q, Wang X, Wang S, Jin L, Ding J, Zhou D, et al. Gallbladder Cancer Progression Is Reversed by Nanomaterial-Induced Photothermal Therapy in Combination with Chemotherapy and Autophagy Inhibition. Int J Nanomedicine. 2020;15:253-262 pubmed publisher
Yu M, Zeng M, Pan Z, Wu F, Guo L, He G. Discovery of novel akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells. Eur J Med Chem. 2020;189:112076 pubmed publisher
Zheng Y, Zhu G, Yan J, Tang Y, Han S, Yin J, et al. The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation. J Virol. 2020;94: pubmed publisher
Huang S, Wu L, Lee M, Chang C, Cheng W, Fang Y, et al. A robust TDP-43 knock-in mouse model of ALS. Acta Neuropathol Commun. 2020;8:3 pubmed publisher
Liu Y, Fan D. The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K. Nutrients. 2020;12: pubmed publisher
Zhang R, Chen J, Mao L, Guo Y, Hao Y, Deng Y, et al. Nobiletin Triggers Reactive Oxygen Species-Mediated Pyroptosis through Regulating Autophagy in Ovarian Cancer Cells. J Agric Food Chem. 2020;68:1326-1336 pubmed publisher
Xu A, Yang Y, Shao Y, Wu M, Sun Y. Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation. Cell Commun Signal. 2020;18:9 pubmed publisher
Zhang L, Zhou Y, Xia Q, Chen Y, Li J. All-trans-retinal induces autophagic cell death via oxidative stress and the endoplasmic reticulum stress pathway in human retinal pigment epithelial cells. Toxicol Lett. 2020;322:77-86 pubmed publisher
Pan G, Jin L, Shen W, Zhang J, Pan J, Cheng J, et al. Treadmill exercise improves neurological function by inhibiting autophagy and the binding of HMGB1 to Beclin1 in MCAO juvenile rats. Life Sci. 2020;243:117279 pubmed publisher
Lou L, Tian M, Chang J, Li F, Zhang G. MiRNA-192-5p attenuates airway remodeling and autophagy in asthma by targeting MMP-16 and ATG7. Biomed Pharmacother. 2020;122:109692 pubmed publisher
Xia B, Yu J, He T, Liu X, Su J, Wang M, et al. Lactobacillus johnsonii L531 ameliorates enteritis via elimination of damaged mitochondria and suppression of SQSTM1-dependent mitophagy in a Salmonella infantis model of piglet diarrhea. FASEB J. 2020;34:2821-2839 pubmed publisher
Koller E, Gonzalez De La Cruz E, Weinrich M, Williams T, Cruz P, Ryu D, et al. Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy. Mol Neurobiol. 2020;: pubmed publisher
Liu Q, Zhao M, Chen W, Xu K, Huang F, Qu J, et al. Mainstream cigarette smoke induces autophagy and promotes apoptosis in oral mucosal epithelial cells. Arch Oral Biol. 2020;111:104646 pubmed publisher
Wu Q, Zhang M, Liu X, Zhang J, Wang H. CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus. Int J Mol Med. 2020;45:475-484 pubmed publisher
Liu J, Zhu Z, Liu Y, Wei L, Li B, Mao F, et al. MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of berberine in p53-null leukemic cells. Life Sci. 2020;242:117228 pubmed publisher
Ying C, Ying L, Yanxia L, Le W, Lili C. High mobility group box 1 antibody represses autophagy and alleviates hippocampus damage in pilocarpine-induced mouse epilepsy model. Acta Histochem. 2020;122:151485 pubmed publisher
Wang Y, Ji L, Peng Z, Lai R, Zhang X, Xu Y, et al. Silencing DAPK3 blocks the autophagosome-lysosome fusion by mediating SNAP29 in trophoblast cells under high glucose treatment. Mol Cell Endocrinol. 2020;502:110674 pubmed publisher
Hu L, Wang J, Chen X, Yan Y. Lanosterol modulates proteostasis via dissolving cytosolic sequestosomes/aggresome-like induced structures. Biochim Biophys Acta Mol Cell Res. 2020;1867:118617 pubmed publisher
Xu D, Liu J, Ma H, Guo W, Wang J, Kan X, et al. Schisandrin A protects against lipopolysaccharide-induced mastitis through activating Nrf2 signaling pathway and inducing autophagy. Int Immunopharmacol. 2020;78:105983 pubmed publisher
You Z, Jiang W, Qin L, Gong Z, Wan W, Li J, et al. Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress. Nat Commun. 2019;10:5792 pubmed publisher
Wang J, Li L, Wang J, Song L, Tan N, Wang Z. Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells. Cells. 2019;8: pubmed publisher
Qin S, Jiang C, Gao J. Transcriptional factor Nrf2 is essential for aggresome formation during proteasome inhibition. Biomed Rep. 2019;11:241-252 pubmed publisher
Guo X, Zhang Y, Lu C, Qu F, Jiang X. Protective effect of hyperoside on heart failure rats via attenuating myocardial apoptosis and inducing autophagy. Biosci Biotechnol Biochem. 2019;:1-11 pubmed publisher
Hussain T, Zhao D, Shah S, Sabir N, Wang J, Liao Y, et al. PP2Ac Modulates AMPK-Mediated Induction of Autophagy in Mycobacterium bovis-Infected Macrophages. Int J Mol Sci. 2019;20: pubmed publisher
Wu X, Sun R, Wang H, Yang B, Wang F, Xu H, et al. Enhanced p62-NRF2 Feedback Loop due to Impaired Autophagic Flux Contributes to Arsenic-Induced Malignant Transformation of Human Keratinocytes. Oxid Med Cell Longev. 2019;2019:1038932 pubmed publisher
Wang H, Peng X, Huang Y, Xiao Y, Wang Z, Zhan L. Propofol Attenuates Hypoxia/Reoxygenation-Induced Apoptosis and Autophagy in HK-2 Cells by Inhibiting JNK Activation. Yonsei Med J. 2019;60:1195-1202 pubmed publisher
Wang Y, Huang Y, Liu J, Zhang J, Xu M, You Z, et al. Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB. EMBO Rep. 2019;:e48335 pubmed publisher
Xu W, Zheng H, Yang R, Liu T, Yu W, Zheng X, et al. Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy. Exp Mol Med. 2019;51:140 pubmed publisher
Xiao Y, Wei R, Yuan Z, Lan X, Kuang J, Hu D, et al. Rutin suppresses FNDC1 expression in bone marrow mesenchymal stem cells to inhibit postmenopausal osteoporosis. Am J Transl Res. 2019;11:6680-6690 pubmed
Kuang M, Li L, Li C, Wang G. Protective effects of UFL1 against endoplasmic reticulum stress-induced autophagy in bovine mammary epithelial cells. Cell Stress Chaperones. 2019;24:1115-1125 pubmed publisher
Luo J, Long Y, Ren G, Zhang Y, Chen J, Huang R, et al. Punicalagin Reversed the Hepatic Injury of Tetrachloromethane by Antioxidation and Enhancement of Autophagy. J Med Food. 2019;22:1271-1279 pubmed publisher
Xiong Y, Hou T, Liu L, Peng W, Wang C, Lu Y, et al. Solanesol derived therapeutic carriers for anticancer drug delivery. Int J Pharm. 2019;572:118823 pubmed publisher
Wang D, Guo H, Yang H, Wang D, Gao P, Wei W. Pterostilbene, An Active Constituent of Blueberries, Suppresses Proliferation Potential of Human Cholangiocarcinoma via Enhancing the Autophagic Flux. Front Pharmacol. 2019;10:1238 pubmed publisher
Guo X, Shi Y, Du P, Wang J, Han Y, Sun B, et al. HMGB1/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA. Life Sci. 2019;239:117020 pubmed publisher
Krans A, Skariah G, Zhang Y, Bayly B, Todd P. Neuropathology of RAN translation proteins in fragile X-associated tremor/ataxia syndrome. Acta Neuropathol Commun. 2019;7:152 pubmed publisher
Sacino A, Prokop S, Walsh M, Adamson J, Subramony S, Krans A, et al. Fragile X-associated tremor ataxia syndrome with co-occurrent progressive supranuclear palsy-like neuropathology. Acta Neuropathol Commun. 2019;7:158 pubmed publisher
Hu B, Song W, Tang Y, Shi M, Li H, Yu D. Induction of Chemerin on Autophagy and Apoptosis in Dairy Cow Mammary Epithelial Cells. Animals (Basel). 2019;9: pubmed publisher
Wang N, Yang B, Muhetaer G, Wang S, Zheng Y, Lu J, et al. XIAOPI formula promotes breast cancer chemosensitivity via inhibiting CXCL1/HMGB1-mediated autophagy. Biomed Pharmacother. 2019;120:109519 pubmed publisher
Wang X, Jiang L, Shi L, Yao K, Sun X, Yang G, et al. Zearalenone induces NLRP3-dependent pyroptosis via activation of NF-κB modulated by autophagy in INS-1 cells. Toxicology. 2019;428:152304 pubmed publisher
Ma H, Su L, He X, Miao J. Loss of HMBOX1 promotes LPS-induced apoptosis and inhibits LPS-induced autophagy of vascular endothelial cells in mouse. Apoptosis. 2019;24:946-957 pubmed publisher
Irungbam K, Churin Y, Matono T, Weglage J, Ocker M, Glebe D, et al. Cannabinoid receptor 1 knockout alleviates hepatic steatosis by downregulating perilipin 2. Lab Invest. 2019;: pubmed publisher
Huo T, Jia Y, Yin C, Luo X, Zhao J, Wang Z, et al. Iron dysregulation in vascular dementia: Focused on the AMPK/autophagy pathway. Brain Res Bull. 2019;153:305-313 pubmed publisher
Xu B, Lang L, Li S, Yuan J, Wang J, Yang H, et al. Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure. Animals (Basel). 2019;9: pubmed publisher
Liang J, Zhou F, Xiong X, Zhang X, Li S, Li X, et al. Enhancing the retrograde axonal transport by curcumin promotes autophagic flux in N2a/APP695swe cells. Aging (Albany NY). 2019;11:7036-7050 pubmed publisher
Wang Z, Zhang M, Shan R, Wang Y, Chen J, Huang J, et al. MTMR3 is upregulated in patients with breast cancer and regulates proliferation, cell cycle progression and autophagy in breast cancer cells. Oncol Rep. 2019;42:1915-1923 pubmed publisher
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product information
CatalogNo :
18420-1-AP
AntigenName :
P62/SQSTM1
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
sequestosome 1
Immunogen :
Fusion Protein
Species :
bovine, chick, chicken, cow, goat, hamster, human, monopterus albus, mouse, rabbit, rat, swine, zebrafish
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, FC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
ORCA, OSIL, p60, P62, p62B, PDB3, sequestosome 1, SQSTM1, Ubiquitin binding protein p62
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC017222
Category :
Apoptosis;Binding Proteins;Cytoskeleton/Scaffold Proteins;Immunology;Metabolism;Signal transduction;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
FC 1:0 ; IF 1:50 ; IHC 1:50 ; IP 1:1000 ; WB 1:4000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.