This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
CYP3A4
catalog :
18227-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
citations: 12
Reference
Li A, Gao S, Guo M, Jing C. CYP3A4 and microRNA-122 are involved in the apoptosis of HepG2 cells induced by ILs 1-decyl-3-methylimidazolium bromide. J Biochem Mol Toxicol. 2019;:e22419 pubmed publisher
Xu L, Zhang Y, Zhang P, Dai X, Gao Y, Lv Y, et al. Integrated Metabolomics and Network Pharmacology Strategy-Driven Active Traditional Chinese Medicine Ingredients Discovery for the Alleviation of Cisplatin Nephrotoxicity. Chem Res Toxicol. 2019;32:2411-2421 pubmed publisher
Wang Z, Li W, Jing H, Ding M, Fu G, Yuan T, et al. Generation of hepatic spheroids using human hepatocyte-derived liver progenitor-like cells for hepatotoxicity screening. Theranostics. 2019;9:6690-6705 pubmed publisher
Minami T, Ishii T, Yasuchika K, Fukumitsu K, Ogiso S, Miyauchi Y, et al. Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold. Regen Ther. 2019;10:127-133 pubmed publisher
Hu Q, Yao N, Wu J, Liu M, Liu F, Zhang H, et al. Constitutive androstane receptor weakens the induction of panaxytriol on CYP3A4 by repressing the activation of pregnane X receptor. Biochem Pharmacol. 2019;159:32-39 pubmed publisher
Wang C, Xu W, Zhang Y, Huang D, Huang K. Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity. Cell Death Dis. 2018;9:819 pubmed publisher
He L, Li H, Huang N, Zhou X, Tian J, Li T, et al. Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway. Oncotarget. 2017;8:102974-102988 pubmed publisher
Sriwattanapong K, Slocum S, Chawanthayatham S, Fedeles B, Egner P, Groopman J, et al. Editor's Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver. Toxicol Sci. 2017;160:173-179 pubmed publisher
Luo W, Xin Y, Zhao X, Zhang F, Liu C, Fan H, et al. Suppression of carboxylesterases by imatinib mediated by the down-regulation of pregnane X receptor. Br J Pharmacol. 2017;174:700-717 pubmed publisher
Zhang B, Liu Y, Li X. Alteration in the expression of cytochrome P450s (CYP1A1, CYP2E1, and CYP3A11) in the liver of mouse induced by microcystin-LR. Toxins (Basel). 2015;7:1102-15 pubmed publisher
Wang Y, Yang J, Liu H, Lin F, Shi J, Zhang F. Effects of tetrahydroxystilbene glucoside on mouse liver cytochrome P450 enzyme expressions. Xenobiotica. 2015;45:279-85 pubmed publisher
Lv L, Han Q, Chu Y, Zhang M, Sun L, Wei W, et al. Self-renewal of hepatoblasts under chemically defined conditions by iterative growth factor and chemical screening. Hepatology. 2015;61:337-47 pubmed publisher
product information
CatalogNo :
18227-1-AP
AntigenName :
CYP3A4
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
cytochrome P450, family 3, subfamily A, polypeptide 4
Immunogen :
Recombinant Protein
Species :
human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
Albendazole monooxygenase, Albendazole sulfoxidase, CP33, CP34, CYP3A, CYP3A11, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF 25, Cytochrome P450 PCN1, HLP, NF 25, Nifedipine oxidase, P450C3, P450PCN1, Quinine 3 monooxygenase
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC101631
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Disease Related;Membrane Proteins;Metabolism;Signal transduction;Transport/Trafficking;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
AppTiter :
IHC 1:200 ; WB 1:6000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.