This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
MMP13
catalog :
18165-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 60
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4c
Yang H, Zhang M, Liu Q, Zhang H, Zhang J, Lu L, et al. Inhibition of Ihh Reverses Temporomandibular Joint Osteoarthritis via a PTH1R Signaling Dependent Mechanism. Int J Mol Sci. 2019;20: pubmed publisher
Wang X, Li D, Wu H, Liu F, Liu F, Zhang Q, et al. LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding. Mech Ageing Dev. 2020;190:111293 pubmed publisher
Bellini M, Pest M, Miranda Rodrigues M, Qin L, Jeong J, Beier F. Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice. Arthritis Res Ther. 2020;22:119 pubmed publisher
Luo P, Peng S, Yan Y, Ji P, Xu J. IL-37 inhibits M1-like macrophage activation to ameliorate temporomandibular joint inflammation through the NLRP3 pathway. Rheumatology (Oxford). 2020;: pubmed publisher
Yan Z, Lin Z, Wu Y, Zhan J, Qi W, Lin J, et al. The protective effect of myricitrin in osteoarthritis: An in vitro and in vivo study. Int Immunopharmacol. 2020;84:106511 pubmed publisher
Wen X, Li H, Sun H, Zeng A, Lin R, Zhao J, et al. MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway. Life Sci. 2020;253:117718 pubmed publisher
Shen X, Cheng Y, Dong Q, Zheng M. MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5. Biochem Biophys Res Commun. 2020;527:458-465 pubmed publisher
Schoenenberger A, Tempfer H, Lehner C, Egloff J, Mauracher M, Bird A, et al. Macromechanics and polycaprolactone fiber organization drive macrophage polarization and regulate inflammatory activation of tendon in vitro and in vivo. Biomaterials. 2020;249:120034 pubmed publisher
Zhang X, Huang C, Pan S, Pang Y, Chen Y, Zha G, et al. Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression. Int Immunopharmacol. 2020;83:106425 pubmed publisher
Cirrincione A, Pellegrini A, Dominy J, Benjamin M, Utkina Sosunova I, Lotti F, et al. Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation. Sci Rep. 2020;10:3970 pubmed publisher
Wang X, Tang L, Zhang Z, Li W, Chen Y. Keratocytes promote corneal neovascularization through VEGFr3 induced by PPARα-inhibition. Exp Eye Res. 2020;193:107982 pubmed publisher
Govindappa P, Patil M, Garikipati V, Verma S, Saheera S, Narasimhan G, et al. Targeting exosome-associated human antigen R attenuates fibrosis and inflammation in diabetic heart. FASEB J. 2020;34:2238-2251 pubmed publisher
Chu J, Yan B, Zhang J, Peng L, Ao X, Zheng Z, et al. Casticin Attenuates Osteoarthritis-Related Cartilage Degeneration by Inhibiting the ROS-Mediated NF-κB Signaling Pathway in vitro and in vivo. Inflammation. 2020;: pubmed publisher
Jiang M, He J, Gu H, Yang Y, Huang Y, Xu X, et al. Protective effect of resveratrol on obesity-related osteoarthritis via alleviating JAK2/STAT3 signaling pathway is independent of SOCS3. Toxicol Appl Pharmacol. 2020;388:114871 pubmed publisher
Tu Y, Ma T, Wen T, Yang T, Xue L, Cai M, et al. MicroRNA-377-3p alleviates IL-1β-caused chondrocyte apoptosis and cartilage degradation in osteoarthritis in part by downregulating ITGA6. Biochem Biophys Res Commun. 2020;523:46-53 pubmed publisher
Lv S, Wang F, Wang K, Fan Y, Xu J, Zheng J, et al. IκB kinase α: an independent prognostic factor that promotes the migration and invasion of oral squamous cell carcinoma. Br J Oral Maxillofac Surg. 2019;: pubmed publisher
Gao X, Jiang S, Du Z, Ke A, Liang Q, Li X. KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo. Oxid Med Cell Longev. 2019;2019:8564681 pubmed publisher
Wang X, Lin L, Chai X, Wu Y, Li Y, Liu X. Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts. Int J Mol Med. 2019;: pubmed publisher
Wang S, Yao Y, Wang X, Zheng G, Ouyang W, Chen W. 25-HC promotes hepatocellular carcinoma metastasis through up-regulation of TLR4 dependent FABP4. Am J Cancer Res. 2019;9:2140-2155 pubmed
Miyauchi A, Kim Kaneyama J, Lei X, Chang S, Saito T, Haraguchi S, et al. Alleviation of murine osteoarthritis by deletion of the focal adhesion mechanosensitive adapter, Hic-5. Sci Rep. 2019;9:15770 pubmed publisher
Wu X, Liao Z, Wang K, Hua W, Liu X, Song Y, et al. Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc. Exp Mol Med. 2019;51:110 pubmed publisher
Hu Y, Gui Z, Zhou Y, Xia L, Lin K, Xu Y. Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages. Free Radic Biol Med. 2019;145:146-160 pubmed publisher
Zhao L, Xiao E, He L, Duan D, He Y, Chen S, et al. Reducing macrophage numbers alleviates temporomandibular joint ankylosis. Cell Tissue Res. 2019;: pubmed publisher
Son K, Jung H, Hong J, Park I, Kim H. Development of a Mouse Model of Knee Osteoarthritis Based on Obesity and Bipedal Walking. J Orthop Res. 2019;: pubmed publisher
Cecen B, Keles D, Oktay G, Kozaci L. Effects of simvastatin on matrix metalloproteinase regulation in IL-1β-induced SW1353 cells. Chem Biol Interact. 2019;310:108730 pubmed publisher
Lin Z, Wu D, Huang L, Jiang C, Pan T, Kang X, et al. Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice. Front Pharmacol. 2019;10:570 pubmed publisher
Oichi T, Taniguchi Y, Soma K, Oshima Y, Yano F, Mori Y, et al. Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway. Cell Mol Life Sci. 2019;: pubmed publisher
Li X, Liu Y, Yue W, Tan Y, Wang H, Zhang L, et al. A Compound of Chinese Herbs Protects against Alcoholic Liver Fibrosis in Rats via the TGF-β1/Smad Signaling Pathway. Evid Based Complement Alternat Med. 2019;2019:9121347 pubmed publisher
Wang J, Du L, Fu Y, Jiang P, Wang X. ZnO nanoparticles inhibit the activity of Porphyromonas gingivalis and Actinomyces naeslundii and promote the mineralization of the cementum. BMC Oral Health. 2019;19:84 pubmed publisher
Xue H, Tu Y, Ma T, Wen T, Yang T, Xue L, et al. miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4. Bone. 2019;123:129-136 pubmed publisher
Wu J, Kuang L, Chen C, Yang J, Zeng W, Li T, et al. miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis. Biomaterials. 2019;206:87-100 pubmed publisher
Yao Z, Chen P, Wang S, Deng G, Hu Y, Lin Q, et al. Reduced PDGF-AA in subchondral bone leads to articular cartilage degeneration after strenuous running. J Cell Physiol. 2019;: pubmed publisher
Zhao Y, Li Y, Qu R, Chen X, Wang W, Qiu C, et al. Cortistatin binds to TNF-α receptors and protects against osteoarthritis. EBioMedicine. 2019;41:556-570 pubmed publisher
Wang S, Yao Y, Rao C, Zheng G, Chen W. 25-HC decreases the sensitivity of human gastric cancer cells to 5-fluorouracil and promotes cells invasion via the TLR2/NF-κB signaling pathway. Int J Oncol. 2019;54:966-980 pubmed publisher
Du M, Wang Y, Liu Z, Wang L, Cao Z, Zhang C, et al. Effects of IL-1β on MMP-9 Expression in Cementoblast-Derived Cell Line and MMP-Mediated Degradation of Type I Collagen. Inflammation. 2019;42:413-425 pubmed publisher
Wang J, Wang K, Huang C, Lin D, Zhou Y, Wu Y, et al. SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis. Int J Biol Sci. 2018;14:1873-1882 pubmed publisher
Wang Q, Tan Q, Xu W, Kuang L, Zhang B, Wang Z, et al. Postnatal deletion of Alk5 gene in meniscal cartilage accelerates age-dependent meniscal degeneration in mice. J Cell Physiol. 2018;234:595-605 pubmed publisher
Dumortier M, Ladam F, Damour I, Vacher S, Bieche I, Marchand N, et al. ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis. Breast Cancer Res. 2018;20:73 pubmed publisher
Ding Q, Ye C, Chen E, Zhang W, Wang X. Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo. Int Immunopharmacol. 2018;61:222-230 pubmed publisher
Katsara O, Kolupaeva V. mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation, precedes cartilage degeneration in rat osteoarthritic knees. J Orthop Res. 2018;36:2728-2735 pubmed publisher
Wang Z, Huang J, Zhou S, Luo F, Tan Q, Sun X, et al. Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint. J Biol Chem. 2018;293:8761-8774 pubmed publisher
Ye T, Sun D, Mu T, Chu Y, Miao H, Zhang M, et al. Differential effects of high-physiological oestrogen on the degeneration of mandibular condylar cartilage and subchondral bone. Bone. 2018;111:9-22 pubmed publisher
Xie Y, Wen H, Yan K, Wang S, Wang X, Chen J, et al. Toxoplasma gondii GRA15II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica. Cell Mol Immunol. 2018;15:120-134 pubmed publisher
Shen Y, Guo D, Weng L, Wang S, Ma Z, Yang Y, et al. Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway. Oncoimmunology. 2017;6:e1362527 pubmed publisher
Cai Y, Zhang M, Qiu X, Wang B, Fu Y, Zeng J, et al. Upregulation of FBXW7 Suppresses Renal Cancer Metastasis and Epithelial Mesenchymal Transition. Dis Markers. 2017;2017:8276939 pubmed publisher
Higuchi Y, Nishida Y, Kozawa E, Zhuo L, Arai E, Hamada S, et al. Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model. Sci Rep. 2017;7:7028 pubmed publisher
Wang Q, Tan Q, Xu W, Qi H, Chen D, Zhou S, et al. Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice. Osteoarthritis Cartilage. 2017;25:1868-1879 pubmed publisher
Liu C, Zhang Y, Dai B, Ma Y, Zhang Q, Wang Y, et al. Chlorogenic acid prevents inflammatory responses in IL‑1β‑stimulated human SW‑1353 chondrocytes, a model for osteoarthritis. Mol Med Rep. 2017;16:1369-1375 pubmed publisher
Zeng L, Rong X, Li R, Wu X. Icariin inhibits MMP‑1, MMP‑3 and MMP‑13 expression through MAPK pathways in IL‑1β‑stimulated SW1353 chondrosarcoma cells. Mol Med Rep. 2017;15:2853-2858 pubmed publisher
Zhou S, Lu W, Chen L, Ge Q, Chen D, Xu Z, et al. AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice. Sci Rep. 2017;7:43245 pubmed publisher
Zeng L, Xiao C, Deng Z, Li R. Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model. Evid Based Complement Alternat Med. 2017;2017:8985623 pubmed publisher
Suzuki S, Fujita N, Fujii T, Watanabe K, Yagi M, Tsuji T, et al. Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration. Spine (Phila Pa 1976). 2017;42:E817-E824 pubmed publisher
Zhou S, Wang Z, Tang J, Li W, Huang J, Xu W, et al. Exogenous fibroblast growth factor 9 attenuates cartilage degradation and aggravates osteophyte formation in post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2016;24:2181-2192 pubmed publisher
Zhou S, Xie Y, Li W, Huang J, Wang Z, Tang J, et al. Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice. Sci Rep. 2016;6:24039 pubmed publisher
Wei H, Yang S, Bai Z, Zhang X, Yang D, Ding W. Levofloxacin increases apoptosis of rat annulus fibrosus cells via the mechanism of upregulating MMP-2 and MMP-13. Int J Clin Exp Med. 2015;8:20198-207 pubmed
Hong J, Liu R, Chen L, Wu B, Yu J, Gao W, et al. Conditional knockout of tissue factor pathway inhibitor 2 in vascular endothelial cells accelerates atherosclerotic plaque development in mice. Thromb Res. 2016;137:148-156 pubmed publisher
Pest M, Pest C, Bellini M, Feng Q, Beier F. Deletion of Dual Specificity Phosphatase 1 Does Not Predispose Mice to Increased Spontaneous Osteoarthritis. PLoS ONE. 2015;10:e0142822 pubmed publisher
Moon P, Penuela S, Barr K, Khan S, Pin C, Welch I, et al. Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis. J Mol Med (Berl). 2015;93:845-56 pubmed publisher
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, et al. Potent effects of dioscin against liver fibrosis. Sci Rep. 2015;5:9713 pubmed publisher
Yang S, Yang D, Sun Y, Wang B, Ma L, Feng S, et al. 17β-estradiol protects against apoptosis induced by interleukin-1β in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13. Apoptosis. 2015;20:348-57 pubmed publisher
product information
CatalogNo :
18165-1-AP
AntigenName :
MMP13
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
matrix metallopeptidase 13
Immunogen :
Recombinant Protein
Species :
human, mouse, rabbit, rat, zebrafish
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
CLG3, Matrix metalloproteinase 13, MMP 13, MMP13
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC074808
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
AppTiter :
IF 1:25 ; IHC 1:200 ; IP 1:300 ; WB 1:500 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.