This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
MMP3
catalog :
17873-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 46
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 5c
Ohnishi T, Yamada K, Iwasaki K, Tsujimoto T, Higashi H, Kimura T, et al. Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging. Sci Rep. 2019;9:19324 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 5b
Nakamura D, Hollander J, Uchimura T, Nielsen H, Zeng L. Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions. BMC Musculoskelet Disord. 2017;18:39 pubmed publisher
He X, Huang Z, Liu P, Li Q, Wang M, Qiu M, et al. Apatinib Inhibits the Invasion and Metastasis of Liver Cancer Cells by Downregulating MMP-Related Proteins via Regulation of the NF-κB Signaling Pathway. Biomed Res Int. 2020;2020:3126182 pubmed publisher
Wu Y, Wang Z, Lin Z, Fu X, Zhan J, Yu K. Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo. Front Pharmacol. 2020;11:682 pubmed publisher
Ni B, Huang X, Xi Y, Mao Z, Chu X, Zhang R, et al. Neferine Inhibits Expression of Inflammatory Mediators and Matrix Degrading Enzymes in IL-1β-Treated Rat Chondrocytes via Suppressing MAPK and NF-κB Signaling Pathways. Inflammation. 2020;43:1209-1221 pubmed publisher
Yang R, Chen J, Zhang J, Qin R, Wang R, Qiu Y, et al. 1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis. Aging Cell. 2020;19:e13095 pubmed publisher
Zhan S, Wang K, Xiang Q, Song Y, Li S, Liang H, et al. lncRNA HOTAIR upregulates autophagy to promote apoptosis and senescence of nucleus pulposus cells. J Cell Physiol. 2020;235:2195-2208 pubmed publisher
Gao X, Jiang S, Du Z, Ke A, Liang Q, Li X. KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo. Oxid Med Cell Longev. 2019;2019:8564681 pubmed publisher
Wang S, Yao Y, Wang X, Zheng G, Ouyang W, Chen W. 25-HC promotes hepatocellular carcinoma metastasis through up-regulation of TLR4 dependent FABP4. Am J Cancer Res. 2019;9:2140-2155 pubmed
Wang S, Yao Y, Li H, Zheng G, Lu S, Chen W. Tumor-associated macrophages (TAMs) depend on Shp2 for their anti-tumor roles in colorectal cancer. Am J Cancer Res. 2019;9:1957-1969 pubmed
Wu X, Liao Z, Wang K, Hua W, Liu X, Song Y, et al. Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc. Exp Mol Med. 2019;51:110 pubmed publisher
Huang X, Ni B, Mao Z, Xi Y, Chu X, Zhang R, et al. NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway. J Cell Mol Med. 2019;: pubmed publisher
Wu Y, Lin Z, Yan Z, Wang Z, Fu X, Yu K. Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways. Int Immunopharmacol. 2019;75:105715 pubmed publisher
Li X, Huang Y, Guo S, Xie M, Bin X, Shi M, et al. Exogenous regucalcin negatively regulates the progression of cervical adenocarcinoma. Oncol Lett. 2019;18:609-616 pubmed publisher
Son K, Jung H, Hong J, Park I, Kim H. Development of a Mouse Model of Knee Osteoarthritis Based on Obesity and Bipedal Walking. J Orthop Res. 2019;: pubmed publisher
Cecen B, Keles D, Oktay G, Kozaci L. Effects of simvastatin on matrix metalloproteinase regulation in IL-1β-induced SW1353 cells. Chem Biol Interact. 2019;310:108730 pubmed publisher
Jin Y, Li Y, Wang X, Yang Y. Dysregulation of MiR-519d Affects Oral Squamous Cell Carcinoma Invasion and Metastasis by Targeting MMP3. J Cancer. 2019;10:2720-2734 pubmed publisher
Wang Y, He G, Tang H, Shi Y, Kang X, Lyu J, et al. Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway. Cell Prolif. 2019;52:e12650 pubmed publisher
Lin Z, Wu D, Huang L, Jiang C, Pan T, Kang X, et al. Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice. Front Pharmacol. 2019;10:570 pubmed publisher
Simão M, Gavaia P, Camacho A, Porto G, Pinto I, Ea H, et al. Intracellular iron uptake is favored in Hfe-KO mouse primary chondrocytes mimicking an osteoarthritis-related phenotype. Biofactors. 2019;45:583-597 pubmed publisher
Li H, Tong X, Xu Y, Wang M, Dai H, Shi T, et al. Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer. Carcinogenesis. 2019;: pubmed publisher
Yao Y, Rao C, Zheng G, Wang S. Luteolin suppresses colorectal cancer cell metastasis via regulation of the miR‑384/pleiotrophin axis. Oncol Rep. 2019;42:131-141 pubmed publisher
Aftab Q, Mesnil M, Ojefua E, Poole A, Noordenbos J, Strale P, et al. Cx43-Associated Secretome and Interactome Reveal Synergistic Mechanisms for Glioma Migration and MMP3 Activation. Front Neurosci. 2019;13:143 pubmed publisher
Xue H, Tu Y, Ma T, Wen T, Yang T, Xue L, et al. miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4. Bone. 2019;123:129-136 pubmed publisher
Wang Y, Lv Y, Liu T, Yan W, Chen L, Li Z, et al. Cordycepin suppresses cell proliferation and migration by targeting CLEC2 in human gastric cancer cells via Akt signaling pathway. Life Sci. 2019;223:110-119 pubmed publisher
Sun J, Zheng B, Sun R, Meng Y, Wang S, Yang H, et al. MiR-499a-5p suppresses apoptosis of human nucleus pulposus cells and degradation of their extracellular matrix by targeting SOX4. Biomed Pharmacother. 2019;113:108652 pubmed publisher
Yu H, Zeng R, Lin Y, Li X, Tasneem S, Yang Z, et al. Kadsura heteroclita stem suppresses the onset and progression of adjuvant-induced arthritis in rats. Phytomedicine. 2019;58:152876 pubmed publisher
Wang S, Yao Y, Rao C, Zheng G, Chen W. 25-HC decreases the sensitivity of human gastric cancer cells to 5-fluorouracil and promotes cells invasion via the TLR2/NF-κB signaling pathway. Int J Oncol. 2019;54:966-980 pubmed publisher
Liang S, Lv Z, Zhang J, Wang Y, Dong Y, Wang Z, et al. Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes. Front Pharmacol. 2018;9:1378 pubmed publisher
Jayatilaka H, Umanzor F, Shah V, Meirson T, Russo G, Starich B, et al. Tumor cell density regulates matrix metalloproteinases for enhanced migration. Oncotarget. 2018;9:32556-32569 pubmed publisher
Ding Q, Ye C, Chen E, Zhang W, Wang X. Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo. Int Immunopharmacol. 2018;61:222-230 pubmed publisher
Katsara O, Kolupaeva V. mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation, precedes cartilage degeneration in rat osteoarthritic knees. J Orthop Res. 2018;36:2728-2735 pubmed publisher
Shen H, Wang H, Wang L, Wang L, Zhu M, Ming Y, et al. Ethanol Extract of Root of Prunus persica Inhibited the Growth of Liver Cancer Cell HepG2 by Inducing Cell Cycle Arrest and Migration Suppression. Evid Based Complement Alternat Med. 2017;2017:8231936 pubmed publisher
Wang J, Wu Y, Guo J, Fei X, Yu L, Ma S. Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells. Oncotarget. 2017;8:81880-81891 pubmed publisher
Wang L, Hu L, Zhou X, Xiong Z, Zhang C, Shehada H, et al. Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling. Sci Rep. 2017;7:13321 pubmed publisher
Wang S, Zhang C, Zhang Z, Qian W, Sun Y, Ji B, et al. Transcriptome analysis in primary colorectal cancer tissues from patients with and without liver metastases using next-generation sequencing. Cancer Med. 2017;6:1976-1987 pubmed publisher
Gao Y, Zhang Z, Li K, Gong L, Yang Q, Huang X, et al. Linc-DYNC2H1-4 promotes EMT and CSC phenotypes by acting as a sponge of miR-145 in pancreatic cancer cells. Cell Death Dis. 2017;8:e2924 pubmed publisher
Zeng L, Rong X, Li R, Wu X. Icariin inhibits MMP‑1, MMP‑3 and MMP‑13 expression through MAPK pathways in IL‑1β‑stimulated SW1353 chondrosarcoma cells. Mol Med Rep. 2017;15:2853-2858 pubmed publisher
Zhou S, Lu W, Chen L, Ge Q, Chen D, Xu Z, et al. AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice. Sci Rep. 2017;7:43245 pubmed publisher
Zeng L, Xiao C, Deng Z, Li R. Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model. Evid Based Complement Alternat Med. 2017;2017:8985623 pubmed publisher
Qu H, Li J, Wu L, Chen W. Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease. Mol Med Rep. 2016;14:2423-30 pubmed publisher
Hu B, Song Z, Liu H, Qiao L, Zhao Y, Wang M, et al. A comparison of incidences of bladder neck contracture of 80- versus 180-W GreenLight laser photoselective vaporization of benign prostatic hyperplasia. Lasers Med Sci. 2016;31:1573-1581 pubmed
Mehner C, Miller E, Nassar A, Bamlet W, Radisky E, Radisky D. Tumor cell expression of MMP3 as a prognostic factor for poor survival in pancreatic, pulmonary, and mammary carcinoma. Genes Cancer. 2015;6:480-9 pubmed
Liu Z, Wei P, Yang Y, Cui W, Cao B, Tan C, et al. BATF2 Deficiency Promotes Progression in Human Colorectal Cancer via Activation of HGF/MET Signaling: A Potential Rationale for Combining MET Inhibitors with IFNs. Clin Cancer Res. 2015;21:1752-63 pubmed publisher
Tan C, Qiao F, Wei P, Chi Y, Wang W, Ni S, et al. DIXDC1 activates the Wnt signaling pathway and promotes gastric cancer cell invasion and metastasis. Mol Carcinog. 2016;55:397-408 pubmed publisher
Yang S, Yang D, Sun Y, Wang B, Ma L, Feng S, et al. 17β-estradiol protects against apoptosis induced by interleukin-1β in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13. Apoptosis. 2015;20:348-57 pubmed publisher
product information
CatalogNo :
17873-1-AP
AntigenName :
MMP3
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
Immunogen :
Recombinant Protein
Species :
calves, human, mouse, rabbit, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IHC, IF, FC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
CHDS6, Matrix metalloproteinase 3, MMP 3, MMP3, SL 1, STMY, STMY1, STR1, Stromelysin 1, Transin 1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC074869
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:100 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.